Neurological complications in dengue infection

Abstract

Complicações neurológicas na infecção por dengue Sir, the recent report on neurological complications in dengue infection is very interesting 1. Puccioni-Sohler et al. noted that "neurological manifestations related to dengue infections are increasingly been observed and appears as a challenge for medical practice." 1 We would like to share the experience on this topic. First, whether the increasing of dengue neurological manifestation is the fact or not should be discussed. In fact, this observation might be due to the increased concern of the practitioner on this problem. According to the previous report from Thailand, the neurological adverse outcome is common in severe dengue Visiting professor,

Neuropsychiatry problem is not the chief clinical presentation of 2014 Western Africa Ebola virus infection

“…Of interest, based on available data from 15 confirmed cases reported from Guinea 1,2,3,4 , no case of patients with confirmed infection has the neuropsychiatry problem as the clinical presentation. In fact, the other viral hemorrhagic fever, such as dengue fever, can have "neuropsychiatry problem" as clinical presentation 5 . Nevertheless, based on present data, no "neuropsychiatry problem" during clinical presentation can be seen.…”

Is there a real increased risk of stroke in patients with dengue fever?

“…Neurologic complication from dengue is possible, but stroke is extremely uncommon. 2 It is unlikely that the present study adequately controlled for the other confounding factors that might result in the occurrence of stroke. If there is an actual increased risk, there should be a plausible pathomechanism.…”

Brain transcriptomics reveals features of the host response after dengue virus type I infection induced central nervous system injury in AGB6 mice

“…Dengue viruses were earlier misidentified as non-neurophilic, and in 2009, the WHO released new guidelines and classifications for dengue, which included CNS involvement in the definition of severe disease [10]. Manifestations of meningitis, encephalitis, Guillain-Barre syndrome (GBS), acute demyelinating encephalopathy (ADEM), myelitis, polyneuropathy, and mononeuropathy [11]. The incidence of encephalopathy and encephalitis, the most common neurological complications of dengue, has been estimated to be between 0.5 and 6.2% [12].…”