Neuromyelitis optica of very late onset: one more case

Abstract

Dear editors, We read with extreme interest the paper by Souza et al. 1 This study describes one case of a 75-year-old woman with neuromyelitis optica (NMO) 1. Including this case, only six cases of neuromyelitis optica developing after the age of 70 have been reported. We think that it is important to describe our recent experience.A 72-year-old Caucasian woman sought our service complaining of a rapidly progressive visual loss in the right eye. After a further week, the other eye was affected, culminating in complete bilateral blindness in less than 15 days. The patient also developed paraparesis, becoming paraplegic in this period. On physical examination she had a T4 sensory level associated with significant dysesthesia. Her magnetic resonance image showed lesions in three contiguous spinal cord levels (T2-T4) and absence of any brain lesions suggestive of multiple sclerosis. Computed tomography scans of the chest, abdomen and pelvis were normal. A CSF analysis showed a cell count of 11 cells/mm 3 (36% lymphocytes, 60% monocytes), glucose 75 mg% and proteins 68 mg%. Tests for syphilis, bacteria, fungi, herpes simplex, herpes zoster, cytomegalovirus, HTLV and HIV were negative. There were no oligoclonal bands. Serum assays on anti-DNA antibodies, anti-nuclear factor, anti-neutrophil cytoplasmic antibodies (p-ANCA and c-ANCA), anti-Ro (SSA), anti-La (SSB), anti-SM and rheumatoid factor, together with the serological test for the human immunodeficiency virus (HIV), were negative. Although she had not been tested for NMO-IgG, our patient fulfilled the diagnostic criteria for neuromyelitis optica 2 . The patient underwent pulse therapy with methylprednisolone for five days 3 . Her visual deficit showed some improvement. Immunoglobulin tests and plasmapheresis were not carried out owing to infectious complications that developed later. Our patient was released from the hospital with oral corticosteroids prescribed. Further evaluation is still necessary to establish whether the patient has shown any further improvement or relapses.

Very late onset neuromyelitis optica spectrum disorders

“…Older patients with NMOSD often present with an insidious onset of symptoms and aggressive progression [18–23], which inspired articles on late onset NMOSD (LO‐NMOSD) [21,24,25]. Although few papers have reported anecdotally on very late onset (VLO)‐NMOSD [18,19,23–26], case series with a focus on VLO‐NMOSD are rare. Therefore, the aim of this retrospective study was to compare the clinical features of VLO‐NMOSD as well as early and late onset groups.…”

“…Older patients with NMOSD often present with an insidious onset of symptoms and aggressive progression [18][19][20][21][22][23], which inspired articles on late onset NMOSD (LO-NMOSD) [21,24,25]. Although few papers have reported anecdotally on very late onset (VLO)-NMOSD [18,19,[23][24][25][26], case series with a focus on VLO-NMOSD are rare.…”

Aging, immunosenescense, and very late-onset neuromyelitis optica spectrum disorders

“…Older patients with NMOSD often present with insidious onset of symptoms and aggressive progression [18][19][20][21][22][23], which inspired articles on late-onset NMOSD (LO-NMOSD) [21,24,25]. Although few papers have reported anecdotally on very lateonset (VLO)-NMOSD [18,19,[23][24][25][26], case series with a focus on VLO-NMOSD are rare. Therefore, the aim of this retrospective study was to identify the clinical features of VLO-NMOSD as compared to early and late onset groups.…”