A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues, David Henrique; Hora, João Sergio Ignácio; Salgado, María; Paes, Renata Alves; Vasconcelos, Cláudia Cristina Ferreira; Landeira-Fernández, J.; Alvarenga, Regina Maria Papais

doi:10.1590/0004-282x20130195

Cited by 5 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect is probably a result of the applied extensive testing in our study and shows that potential attentional performance deficits in patients with Sjögren’s syndrome have hitherto been underestimated. Previously described deficits included mainly memory functions 30,31 or visuospatial/executive functions, 29 which were also significantly impaired in our cohort (Semantic and Phonemic Fluency and Wordlist Learning Subtests).…”

Section: Discussionsupporting

confidence: 54%

Cognitive impairment in patients with Neuro‐Sjögren

Seeliger

Jacobsen

Hendel

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity of Neuro‐Sjögren. Neuropsychological assessment of patients with Sjögren’s syndrome has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety of prevalence rates for cognitive impairment (22–80%), while variable cut‐off criteria for detection of cognitive impairment were applied. Attentional functions have not yet been thoroughly investigated in these patients, although they clearly represent relevant aspects of cognitive functioning in daily life. Methods We therefore conducted extensive neuropsychological assessment based on two neuropsychological test batteries [i.e., the extended German version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD‐PLUS), and the test battery for attentional performance (TAP) as a well‐established assessment of attentional functions in the German‐speaking part of Europe]. Results Sixty‐four patients with Neuro‐Sjögren, who were treated at our university hospital between December 2016 and January 2019, were included. Evidence for the presence of cognitive impairment was found in 55% of patients with Neuro‐Sjögren. The degree of cognitive impairment ranged from mild (38%) to severe (17%). Attentional and mnemonic subtests showed pronounced cognitive impairment in patients with Neuro‐Sjögren. Interpretation Our results suggest that a substantial proportion of patients with Neuro‐Sjögren suffer from cognitive impairment, putatively as a corollary of attentional deficits, which might exert adverse effects on occupational abilities, other cognitive functions, and social role functioning.

show abstract

Section: Discussionsupporting

confidence: 54%

Cognitive impairment in patients with Neuro‐Sjögren

Seeliger

Jacobsen

Hendel

et al. 2020

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…The sample sizes in these studies ranged from 36 to 2 454 458. Fourteen studies included only PSS patients [21][22][23][24][25][26][27][28][29][30]35,38,39,41 and the remaining eight studies involved DED patients that were defined by an assortment of clinical dry eyes parameters such as Ocular Surface Disease Index, tear break up time, or Schirmer's test. [31][32][33][34]36,37,40,42 Different instruments and scales were used to assess for the presence and the degree of depression and anxiety.…”

Section: Discussionmentioning

confidence: 99%

Depression and anxiety in dry eye disease: a systematic review and meta-analysis

Wan

Chen

Young

2016

Eye

141

114

View full text Add to dashboard Cite

AimTo evaluate the association of dry eye disease (DED) with depression and anxiety.Patients and methodsWe conducted a systematic review and meta-analysis of studies that reported the prevalence, incidence and/or severity grading of depression and/or anxiety in DED patients and healthy controls. We searched MEDLINE, EMBASE, PsycINFO, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform for relevant studies.ResultsTwenty-two eligible studies consisted of 2 980 026 patients were analyzed. DED was associated with an increased prevalence of depression (summary odds ratio (OR)=2.92, 95% CI: 2.13-4.01, P<0.00001) and anxiety (OR=2.80, 95% CI: 2.61-3.02, P<0.00001). The depression score (standardized mean difference (SMD)=0.81, 95% CI: 0.48-1.15, P<0.00001) and anxiety score (SMD=0.37, 95% CI: 0.10-0.64, P=0.007) were higher in DED patients than in controls. Subgroup analyses revealed that the prevalence and severity of depression are greatest in primary Sjogren's syndrome patients. No study reported the incidence.ConclusionDepression and anxiety are more prevalent in DED patients than in controls. Among patients with DED, those suffering from primary Sjogren's syndrome have higher prevalence and severity of depression.

show abstract

“…[3][4][5] Cognitive impairment in PSS was reported to be associated with frontal-subcortical dysfunctions including attention, memory, information processing speed and executive functions. [4][5][6][7][8][9][10] Magnetic resonance imaging )MRI( is a potent predictor of subclinical tissue damage and the spread of CNS involvement in Sjögren's patients. 11 Increased white matter abnormality was defined in PSS patients however in some studies, it was not different from the normal population.…”

mentioning

confidence: 99%

“…5 Cognitive impairment in PSS was demonstrated to be associated with frontal-subcortical dysfunctions in attention, memory, information processing speed and executive functions. [4][5][6][7][8][9][10] The low number of sample size can explain no difference between the high-educated group and the control group in the delayed recall of the MoCA test. In the low-educated group, the higher results of the recall with multiple-choice clues might indicate subcortical involvement.…”

mentioning

confidence: 99%

“…Rodriguez et al 10 conducted a short neurological test on 18 PSS patients, 18 Multiple Sclerosis patients and 18 healthy controls and found that patients with PSS scored lower in "executive function and long term memory" tests than healthy controls. Compared with our study, the aforementioned study reported a higher mean age and no information on the duration of the disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Montreal cognitive assessment in primary sjogren’s syndrome

Kurtuluş

Çay

Parlak

et al. 2019

NSJ

View full text Add to dashboard Cite

Objectives: To use the Montreal Cognitive Assessment)MoCA(test to assess the subclinical cognitive impairment in patients with Primary Sjögren's Syndrome)PSS(and assess the correlation of MoCA results with magnetic resonance imaging)MRI(findings in these patients. Methods: The MoCA test was prospectively administered to 32 consecutive patients)31 females, 1 male(diagnosed with PSS and 30 healthy controls)29 females, 1 male(at Antalya Education and Research Hospital between June 2014 and October 2015. Twenty PSS patients underwent a brain MRI)T1, T2, and T2-FLAIR-weighted sequences(. Results: The mean age was 45.84)range 24-63(in the PSS group, and the mean duration of disease was 3.5 years)4 months-18 years(. There were 22 patients)68.80%(with 5-8 years of education and 10 patients)31.30%(with >8 years of education. The mean age was 42.8)28-64(in the control group. There were 20 controls)66.70%(with 5-8 years of education and 10 controls)33.3%(with >8 years of education. The delayed recall rate of the patient group with 5-8 years of education was significantly lower than that of the control group, and the recall rate with multiple choice cues for the same patient group was significantly higher than that of the control group)p<0.05(. There was no correlation between the number of lesions and total MoCA score or subgroups. Conclusion: We suggest that the MoCA test is a single-page, easy-to-administer test, can be used to assess cognition in patients with PSS especially in large groups.

show abstract

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Cited by 5 publications

References 19 publications

Cognitive impairment in patients with Neuro‐Sjögren

Cognitive impairment in patients with Neuro‐Sjögren

Depression and anxiety in dry eye disease: a systematic review and meta-analysis

Montreal cognitive assessment in primary sjogren’s syndrome

Contact Info

Product

Resources

About