Headache classification and aspects of reproductive life in young women

Melhado, Eliana Meire; Bigal, Marcelo E.; Galego, Andressa Regina; Galdezzani, João P.; Queiroz, Luiz Paulo

doi:10.1590/0004-282x20130188

Cited by 5 publications

(4 citation statements)

References 22 publications

(24 reference statements)

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“…Clinically, the onset of migraine attacks coincides with hormonal fluctuations such as those associated with puberty, some oral contraceptives, pregnancy, and menopause [ 22 , 24 – 26 ]. Moreover, it is well accepted that migraine without aura can be triggered by steeply declining levels of ovarian hormones, whereas MA is exacerbated by increasing levels of female reproductive hormones [ 6 , 21 , 27 – 30 ]. Preclinical studies have shown that estrogens, acting through both nuclear α- and β-estrogen receptors as well as GPR30 [ 31 , 32 ], increase cortical excitability and CSD susceptibility in brain slices [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

et al. 2017

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AimsTest the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats.Main MethodsFemale, Sprague-Dawley rats were intact or underwent ovariectomy followed one week later by surgery to place electrodes onto the dura to detect epidural electroencephalographic activity (dEEG). dEEG activity was recorded two days later for 12 hours after systemic administration of 17-β-estradiol (180 μg/kg, i.p.). A separate set of rats were observed for changes in exploratory, ambulatory, fine, and rearing behaviors; periorbital allodynia was also assessed.Key FindingsA bolus of 17-β-estradiol significantly elevated serum estrogen levels, increased SD episodes over a 12-hour recording period and decreased rearing behaviors in ovariectomized rats. Pre-administration of ICI 182,780, an estrogen receptor antagonist, blocked 17-β-estradiol-evoked SD events and pain behaviors; similar results were observed when the antimigraine therapeutic sumatriptan was used.SignificanceThese data indicate that an estrogen receptor-mediated mechanism contributes to SD events in ovariectomized rats and pain behaviors in both ovariectomized -and intact- rats. This suggests that estrogen plays a different role in each phenomenon of migraine where intense fluctuations in concentration may influence SD susceptibility. This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies.

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Section: Introductionmentioning

confidence: 99%

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

et al. 2017

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“…A number of the early articles on headache disorders were published by Farias da Silva and coworkers in the scientific journal Neurobiologia (Recife), which is one of the oldest journals in the area of neurology in Latin America, founded in 1943 by Ulysses Pernambucano. Another important journal containing articles on headache written by Brazilians is Arquivos de Neuropsiquiatria , which was founded in 1945 …”

Section: Publications In Headache Medicinementioning

confidence: 99%

Headache Research and Medical Practice in Brazil: An Historical Overview

2015

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Since the creation of the Brazilian Headache Society in 1978, substantial developments have taken place in both research and clinical practice in the field of headache medicine in Brazil. The Society now has almost 300 members throughout the country, actively working to improve the health of the general population and, in particular, diagnose and treat headache disorders. In addition, in a few large cities, such as São Paulo, Rio de Janeiro, Recife, Ribeirão Preto, Curitiba, and Porto Alegre, headache specialists have come together to promote research projects and increase knowledge in the field through MSc, PhD, and postdoctoral programs. Furthermore, scientific journals have emerged and books have been published to record and disseminate Brazilian scientific production in headache medicine. In this narrative review, we will briefly describe some important aspects of headache medicine in Brazil from prehistoric times to the present day, discuss the origin of headache medicine as a specialty in Brazil, the principal publications dealing with headache disorders, the use of plants and other unconventional forms of treatment used by faith healers, the main training centers, and the research produced to date by Brazilians. In conclusion, in recent years enormous progress has been made in headache medicine in Brazil stimulating us to review and expand our role in an increasingly international scenario.

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“…Migraine is a primary neurologic disorder characterized by headache attacks (1). It is generally unilateral, pulsating in nature, and the frequency of pain decreases with age (2). For many decades, the major contributing factor was thought to be cerebral and meningeal vasodilation (VD).…”

Section: Introductionmentioning

confidence: 99%

Correlations Between Endothelial Dysfunction and Cerebral Imaging in Migraine

Saçmacı¹,

Mirza²,

Bişiren³

et al. 2019

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Objective: Despite its high prevalence, the basic pathophysiologic mechanism of migraine is still poorly understood. Our aim was to research endothelial dysfunction in patients with recently diagnosed episodic migraine, and to determine whether there was a correlation between endothelial dysfunction and white matter lesions (WMLs) on magnetic resonance imaging (MRI). Materials and Methods: This study was conducted between 2013 and 2014. A total of 51 patients and 27 healthy controls were included in the study. MRI was performed in the patient group. Blood samples were collected to investigate serum level of lipids, thyroid hormones, asymmetric dimethyl arginine, and endothelin levels in the patient and control groups. Homeostasis model assessment = insulin resistance factor and brachial artery index flow-mediated dilatation (FMD) were investigated in both groups. Results: WMLs on MRI were present in 40 patients with migraine. FMD was low in patients with migraine (p=0.021). There was a negative correlation between the severity of migraine headache and FMD. A positive correlation was seen between severity of headache and WMLs (p=0.001). The other blood sample concentrations in both the case and control groups were not significantly different. When the blood parameters were evaluated with MRI lesion load, there was a positive correlation with age, cholesterol, low-density lipoprotein, body mass index and triglyceride, and contrary to expectations, there was no relationship with homocysteine. However, there was a significant correlation between insulin resistance and lesion load (p<0.03). Conclusion: In this study, especially in patients with episodic migraine with WMLs, FMD as a marker for endothelial dysfunction was found to be statistically significant. This finding contributes to the pathogenesis of migraine. An endothelial therapeutic drug could be considered as an option, especially in patients who need prophylaxis.

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Headache classification and aspects of reproductive life in young women

Cited by 5 publications

References 22 publications

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

17-β-Estradiol induces spreading depression and pain behavior in alert female rats

Headache Research and Medical Practice in Brazil: An Historical Overview

Correlations Between Endothelial Dysfunction and Cerebral Imaging in Migraine

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