2013
DOI: 10.1590/0004-282x20130046
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Primary neural leprosy: systematic review

Abstract: The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological inve… Show more

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Cited by 33 publications
(29 citation statements)
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“…The involvement of the peripheral nerves is present in all clinical forms of leprosy, and in tuberculoid forms, the nerve damage is usually earlier, while in lepromatous leprosy it appears later 48,51 . This variable is an important epidemiological indicator responsible for causing irreversible consequences, resulting in deformities and disabilities 52,53 .…”
Section: Discussionmentioning
confidence: 99%
“…The involvement of the peripheral nerves is present in all clinical forms of leprosy, and in tuberculoid forms, the nerve damage is usually earlier, while in lepromatous leprosy it appears later 48,51 . This variable is an important epidemiological indicator responsible for causing irreversible consequences, resulting in deformities and disabilities 52,53 .…”
Section: Discussionmentioning
confidence: 99%
“…It is important to remember that indeterminate leprosy lesions are not always anesthetic and peripheral nerve thickness is also found in other neurological diseases. Recently, Brazilian leprosy experts proposed a systematic literature review on the current concepts of PNL consulting online databases (Garbino et al, 2013) 30 . Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the "Oxford Centre for Evidence-based Medicine".…”
Section: Diagnosismentioning
confidence: 99%
“…This clinical form is characterized by no skin lesions and negative slit skin smear bacilloscopy. Therefore, diagnosis is mainly based on supplementary tests, such as electroneuromyography, nerve biopsy, serology and molecular analyses [ 12 , 13 , 14 , 15 , 16 , 17 ]. However, most of the leprosy reference services do not have access to advanced diagnostic methods; therefore, diagnosis is based mainly on clinical manifestations, such as the absence of skin lesions and negative skin smears bacilloscopy.…”
Section: Introductionmentioning
confidence: 99%