Frequency of non-motor symptoms in Peruvian patients with Parkinson's disease

Cosentino, Carlos; Nuñez, Yesenia; Torres, Luís

doi:10.1590/0004-282x20130005

Cited by 21 publications

(17 citation statements)

References 8 publications

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“…Furthermore, research has increasingly focused on non-motor symptoms in PD [14,15]. Depression is one of the most important non-motor symptoms that affects the quality of life of PD patients [14,16]. The pathogenesis underlying depression in PD is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Neuromelanin‐sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes

Wang

Huang

et al. 2018

Euro J of Neurology

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Section: Introductionmentioning

confidence: 99%

Neuromelanin‐sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes

Wang

Huang

et al. 2018

Euro J of Neurology

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“…Furthermore, previous studies on PD patients have reported the prevalence of insomnia symptoms [6,7] or insomnia according to one compound question [8,9] or subthreshold insomnia [10]. Lastly insomnia is known to overlap with multiple medical problems and comorbid sleep disorders.…”

Section: Introductionmentioning

confidence: 99%

Parkinson’s disease and insomnia

Ylikoski¹,

Martikainen²,

Siemiński

et al. 2015

Neurol Sci

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There is a broad spectrum of sleep disturbances observed in Parkinson's disease (PD). The prevalence of symptoms of insomnia and chronic inability to sleep and their association with other sleep disorders were studied. Altogether 1447 randomly selected Parkinson patients, aged 43-89 years, participated in a questionnaire study. A structured questionnaire with 207 items was based on the Basic Nordic Sleep questionnaire. Questions on demographics, PD, REM Sleep Behavior Disorder, and other issues were included. The response rate was 59 % (N = 854), and of these 81 % returned fully answered questionnaire (N = 689). Prevalence of chronic inability to sleep was 36.9 % (95 % CI 33.3-40.5). Difficulty of initiating sleep was 18.0 % (95 % CI 15.1-20.9), disrupted sleep 81.54 % (78.5-84.4), awakenings during night 31.3 % (27.8-34.8), early morning awakenings 40.4 % (36.8-44.1) and non-restorative sleep 38.5 % (34.8-42.1). In the logistic regression models, poor quality of life and restless legs syndrome correlated significantly with chronic insomnia disorder. Disrupted sleep and early morning awakenings were the most common insomnia symptoms. PD patients do not seem to have difficulties in sleep initiation. Insomnia symptoms including disruptive sleep and non-restorative sleep are common in patients with Parkinson's disease. Inability to sleep is more common as comorbidity than a single sleep problem.

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“…Along the initial and moderate phases, several autonomic and neuropsychiatric manifestations may be present, and in the advanced one the most important NMS is dementia of PD. Consentino et al 1 observed that the mean total NMS increased significantly with disease duration. Mean total NMS was 10.74 in patients with less than 5 years of disease, 13.71 between 5 and 9 years, 14.56 between 10 and 14 years and 16.79 in 15 years of disease or more.…”

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confidence: 98%

“…The PRIAMO study (Barone et al 4 ) is another important one to be compared to the Cosentino et al 1 study. This Italian multicenter survey using a semi-structured interview in 1,072 consecutive patients with PD was performed to assess the prevalence NMS in 12 domains, their association with cognitive impairment and the impact on patients' quality of life.…”

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confidence: 99%

Non-motor symptoms in Parkinson's disease

Barbosa¹

2013

Arq. Neuro-Psiquiatr.

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T he classic features of the clinical picture in Parkinson's disease (PD) are the motor disorders: akinesia, rigidity, tremor and postural instability. However, non-motor symptoms (NMS) are frequently present. Therefore, patients with PD can present, besides the typical parkinsonian motor syndrome, a wide arrow of NMS, mainly neuropsychiatric manifestations (as depression and cognitive impairment), sleep disorders (as rapid eye movement behavior disorder), autonomic dysfunctions (as intestinal constipation, postural hypotension and miccional disorders) and others, as fatigue and pain. In their various combinations, NMS may eventually become the main complaints of patients with PD.NMS may be related to the neurodegenerative changes affecting several neural systems and/or caused by drugs employed in the treatment of PD. The mainly neural systems related to NMS are: non-motor frontostriatal circuits, serotoninergic nuclei of median raphe, noradrenergic nuclei (locus coeruleus and subcoeruleus), autonomic centers (hypothalamus and dorsal motor of vagus) and olfactory system.The clinical picture of PD has been compared with an iceberg. The visible part represents the motor symptoms, and the larger non-visible part represents the several NMS, often underecognized in clinical practice.The study of Cosentino et al. 1 published in this issue of Arquivos de Neuropsiquiatria was performed aiming to determine the prevalence of NMS in 300 PD outpatients seen at the Movement Disorders Unit of the Instituto Nacional de Ciencias Neurológicas in Lima, Peru. The patients completed the Spanish validated version of the Non-motor Symptoms Questionnaire (NMSQuest). This questionnaire was developed by Chaudhuri et al.2 to address the need for a quantitative and validated instrument to measure NMS in PD. The NMSQuest is a simple self-completed tool and it is comprised of 30 items grouped according to 9 NMS domains.The results of this study show the high prevalence and the variety of NMS in PD: at least one NMS was present in 99.3% of the patients evaluated and the mean total NMS (NMSQ-T) was 12.41 ranging from 0 to 27 of a maximum of 30. These data confirm those from previous similar studies. Martinez-Martin et al. 3 performed a multicentric, international, cross-sectional study involving 545 PD patients (mean disease duration: 6.96 year) using the same questionnaire (NMSQuest) and reported 10.3 as the mean total NMS, and such symptoms were present in 98.4% of the patients evaluated.The PRIAMO study (Barone et al. 4 ) is another important one to be compared to the Cosentino et al.1 study. This Italian multicenter survey using a semi-structured interview in 1,072 consecutive patients with PD was performed to assess the prevalence NMS in 12 domains, their association with cognitive impairment and the impact on patients' quality of life. They found that 98.6% of patients with PD reported the presence of NMS and the mean number of NMS per patient was 7.8 ranging from 0 to 32.The NMS in PD may be present in all the clinical phases of...

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Frequency of non-motor symptoms in Peruvian patients with Parkinson's disease

Cited by 21 publications

References 8 publications

Neuromelanin‐sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes

Neuromelanin‐sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes

Parkinson’s disease and insomnia

Non-motor symptoms in Parkinson's disease

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