A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

Özek, Sibel Üstün

doi:10.1590/0004-282x-anp-2021-0192

Cited by 3 publications

(3 citation statements)

References 31 publications

(43 reference statements)

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“…Vitamin B12 deficiency in association with hyperhomocysteinemia causes damage to endothelial cells, increasing free radical levels, which may be related to migraine episode generation [192]. Recent studies suggested that a vitamin B12 deficiency in chronic migraine can be induced by the frequent use of analgesics, which may alter vitamin B12 absorption [193]. Thanks to the positive modulation of the gut microbiota by physical exercise, the latter, especially the aerobic type, seems able to prevent the onset of chronic migraine, rather than being able to reduce the symptoms of chronic headaches already existing.…”

Section: Other Vitamin Supplementationsmentioning

confidence: 99%

Section: Other Vitamin Supplementationsmentioning

confidence: 99%

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Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Di Lauro,

Guerriero,

Cornali

et al. 2023

Nutrients

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In the world, migraine is one of the most common causes of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers in combination with a genetic predisposition. Among the factors related to migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut–brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this context, in addition to conventional pharmacological treatments for migraine, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity, and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, such as diabetes mellitus, arterial hypertension, obesity, cancer, and chronic kidney diseases, whose link is represented by gut dysbiosis.

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Section: Other Vitamin Supplementationsmentioning

confidence: 99%

Section: Other Vitamin Supplementationsmentioning

confidence: 99%

Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Di Lauro,

Guerriero,

Cornali

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…The diagnostic criteria in this classification do not include the evaluation of the severity and frequency of painful attacks, which should be evaluated and specified [107,108].…”

Section: Introductionmentioning

confidence: 99%

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Canfora,

Ottaviani,

Calabria

et al. 2023

Biomedicines

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In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, and ICHD-3, for their limitations in addressing COFP’s complexity. Firstly, this study outlines the global burden of chronic pain and the importance of distinguishing between different pain types for effective treatment. It then delves into the specific challenges of diagnosing COFP, emphasizing the need for a more nuanced approach that incorporates the biopsychosocial model. This review critically examines existing classification systems, highlighting their limitations in fully capturing COFP’s multifaceted nature. It advocates for the integration of these systems with the DSM-5’s Somatic Symptom Disorder code, proposing a unified, multidisciplinary diagnostic approach. This recommendation aims to improve chronic pain coding standardization and acknowledge the complex interplay of biological, psychological, and social factors in COFP. In conclusion, here, we highlight the need for a comprehensive, universally applicable classification system for COFP. Such a system would enable accurate diagnosis, streamline treatment strategies, and enhance communication among healthcare professionals. This advancement holds potential for significant contributions to research and patient care in this challenging field, offering a broader perspective for scientists across disciplines.

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Linking Migraine to Gut Dysbiosis And Chronic Non-Communicable Diseases

Di Lauro,

Guerriero,

Cornali

et al. 2023

Preprint

View full text Add to dashboard Cite

In the world, migraine is one of the most common cause of disability in adults. To date, there is no a single cause for this disorder, but rather a set of physio-pathogenic triggers, in combination with a genetic predisposition. Among factors related to the migraine onset, a crucial role seems to be played by gut dysbiosis. In fact, it has been demonstrated how the intestine is able to modulate the central nervous system activities, through the gut-brain axis, and how gut dysbiosis can influence neurological pathologies, including migraine attacks. In this contest, in addition to migraine conventional pharmacological treatments, attention has been paid to an adjuvant therapeutic strategy based on different nutritional approaches and lifestyle changes able to positively modulate the gut microbiota composition. In fact, the restoration of the balance between the different gut bacterial species, the reconstruction of the gut barrier integrity and the control of the release of gut-derived inflammatory neuropeptides, obtained through specific nutritional patterns and lifestyle changes, represent a possible beneficial additive therapy for many migraine subtypes. Herein, this review explores the bi-directional correlation between migraine and the main chronic non-communicable diseases, like diabetes mellitus, arterial hypertension, obesity, cancer and chronic kidney diseases, whose link is represented by gut dysbiosis.

show abstract

A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine

Cited by 3 publications

References 31 publications

Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Linking Migraine to Gut Dysbiosis and Chronic Non-Communicable Diseases

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP)

Linking Migraine to Gut Dysbiosis And Chronic Non-Communicable Diseases

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