Preproghrelin polymorphism Q90L (rs4684677) in gestational diabetes

Molecular studies on preproghrelin gene: alternative splicing, obestatin effects, coding region and variants

“…Furthermore, it was suggested that rs4684677 probably contributes to autoimmune thyroid disease predisposition in a case-control study that investigated polish children (p=0.002) [14], as well as increased women's waist circumference in a Spanish sample population [15]. No significant association was observed in a Brazilian population sample in a study conducted for gestational diabetes [16].…”

“…First, the G protein-coupled receptor-39 (GPR39) was indicated as an obestatin cognate ligand receptor, but this is not supported by several authors, indicating the need for new and more accurate research [4][5][6]. However, that peptide clearly shows an important role in metabolism involved with anti-inflammatory and cardioprotective effects [7][8][9][10][11][12][13][14][15][16][17][18][19]. Furthermore, polymorphisms found in GHRL gene are also being associated with different clinical conditions [20][21][22][23].…”

Impact of gene polymorphism of glutathione S-transferase and ghrelin as a risk factor in Egyptian women with gestational diabetes mellitus

“…The present study revealed that the GHRL gene (G/T rs696217) polymorphism was not significantly associated with gestational diabetes in Egyptian women. Rocha et al revealed that the Gln90Leu polymorphism of the preproghrelin gene was not correlated with gestational diabetes in the Euro-Brazilian population [33]. Kim et al [34] found that the Leu72Met polymorphism of the preproghrelin gene is not related to type 2 diabetes mellitus or to its complications.…”

The association between rs4684677 T/A polymorphism in preproghrelin gene and predisposition to autoimmune thyroid diseases in children

“…We wanted to assess the role of these two polymorphisms in AITDs, as in the current literature they were more frequently responsible for endocrinopathies, such as type 2 diabetes, obesity, insulin resistance, metabolic syndrome, anorexia nervosa. The other polymorphism, such as rs34911341 C4T, is rare [4][5][6][7][8].…”