Menopausa e síndrome metabólica

Meirelles, Ricardo M.R.

doi:10.1590/0004-2730000002909

Cited by 43 publications

(33 citation statements)

References 59 publications

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“…The prevalence of MS among postmenopausal women has been reported to (15), and 64.3% in Iran (16). MS is one factor that increases the mortality rate in both men and women (17). A meta-analysis confirmed this information by describing a higher prevalence of MS during the postmenopausal stage than the premenopausal stage, regardless of population (18).…”

Section: Discussionmentioning

confidence: 87%

Prevalence of metabolic syndrome in pre- and postmenopausal women

Marchi

Dell’Agnolo

Lopes

et al. 2017

Arch. Endocrinol. Metab.

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Objective: The objective of this study was to determine the prevalence of metabolic syndrome (MS) and its components among pre-and postmenopausal women, as well as the association between menopausal status and MS. Materials and methods: A retrospective study was conducted at a reference cardiology outpatient clinic in a city located in Northwestern Paraná State, Brazil. A total of 958 medical records of symptomatic climacteric women evaluated between 2010 and 2014 were analyzed. The study consisted of two groups: pre-and post-menopausal women. MS was characterized according to the criteria of the National Cholesterol Education Program's Adult Treatment Panel III -NCEP-ATP III-2005. Results: MS was observed in 18.5% of the total study population; 9.4% of the premenopausal women and 22.2% of the postmenopausal women displayed MS, corresponding to a relative risk of 2.75. In addition, the frequency of MS increased with age. Regarding the components of MS, postmenopausal women were more likely to have high density lipoprotein (HDL-C) levels < 50 mg/dL; systolic blood pressure (SBP) values ≥ 130 mmHg or diastolic blood pressure (DBP) values ≥ 85 mmHg; and fasting glucose levels ≥ 100 mg/dL. Conclusion: MS was more prevalent among postmenopausal women than among premenopausal women. Arch Endocrinol Metab. 2017;61(2):160-6.

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Section: Discussionmentioning

confidence: 87%

Prevalence of metabolic syndrome in pre- and postmenopausal women

Marchi

Dell’Agnolo

Lopes

et al. 2017

Arch. Endocrinol. Metab.

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“…[11] In another study, it was found that the incidence of positive stress-induced myocardial ischemia, as assessed by the Bruce protocol, was higher in individuals with asymptomatic GD compared to those without GD after adjusting for age, gender, and BMI. [39] A population-based case–control study from the UK demonstrated the likelihood of symptomatic GD to be increased by 30% after adjusting for confounding factors for ischemic heart disease. In a case-controlled GD and breast cancer study conducted in the USA, a strong association was incidentally found between GD and myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…In a case-controlled GD and breast cancer study conducted in the USA, a strong association was incidentally found between GD and myocardial infarction. [39] In the 1980s, the Framingham study showed a prospective, independent association between GD and coronary heart disease. In that study, during 26 years of follow-up, the risk for a first coronary event was two times higher in patients who underwent cholecystectomy due to GD.…”

Section: Discussionmentioning

confidence: 99%

The association between gallstone disease and plaque in the abdominopelvic arteries

et al. 2017

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Background:The aim of this study was to assess the atheromatous plaque, in the abdominopelvic arteries as a marker of cardiac risk in patients with or without gallstone disease (GD).Materials and Methods:A total of 136 patients were enrolled in this cross-sectional study. Forty-eight patients had GD and the remaining 88 patients did not. The presence or absence of gallstones was noted during abdominal ultrasonography while vascular risk factors such as plaque formation, intima-media thickness, plaque calcification, mural thrombus, stenosis, aneurysm, and inflammation were recorded during an abdominopelvic computed tomography scan. In addition, percentage of the abdominopelvic aorta surface covered by atheromatous plaque was calculated.Results:The mean age of patients with GD and without GD was 50.81 ± 16.20 and 50.40 ± 12.43, respectively. Patients with GD were more likely to have diabetes mellitus, a higher body mass index (BMI) (P < 0.001), and higher cholesterol (P < 0.01), and low-density lipoprotein-cholesterol (P < 0.02) levels. No significant differences were found between the groups regarding other atherosclerotic risk factors. Patients with GD had significantly higher rates of the vascular risk factors as intima-media thickness, plaque formation, calcification, aneurysm, mural thrombosis, stenosis, and inflammation in all abdominal arterial segments other than aneurysm in the femoral arteries. In addition, patients with GD had severe atheromatous plaques in the abdominal aorta, common iliac, external iliac, and common femoral artery (CFA). In patients with GD, parameters of age, BMI, and systolic and diastolic blood pressure were all correlated with the severity of the atheromatous plaque in abdominal aorta, common iliac, external iliac, and CFA.Conclusion:We demonstrated a direct relationship between GD and abdominopelvic atheromatous plaque, which is a marker for increased cardiovascular risk, for the first time in the literature. Patients with GD exhibit greater abdominopelvic atherosclerosis and therefore, have a higher risk of cardiovascular disease.

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“…Aunque aumenta con la edad, con la menopausia hay incremento del peso, de la resistencia a la insulina y de la grasa visceral (3) .…”

Section: Introductionunclassified

Síndrome metabólico en el climaterio

Peralta

2018

Rev peru ginecol obstet.

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El aumento de la expectativa de vida de las mujeres se ha traducido en incremento de la morbimortalidad en las mujeres mayores, siendo las enfermedades cardiovasculares una de las más prevalentes. Una de las principales causas de morbilidad es el síndrome metabólico. Es necesario orientar al médico y a sus pacientes sobre las consecuencias de esta patología. Son los varones quienes son más tratados, dejando de lado a las mujeres por la errada percepción de que tienen un riesgo cardiovascular bajo. La fisiopatología de la resistencia a la insulina abre un abanico de conocimientos relacionados al incremento de los triglicéridos en sangre y con el mayor aclaramiento del HDL-colesterol por parte del hígado. La obesidad abdominal y la hipertensión arterial completan los elementos de diagnóstico del síndrome metabólico, el cual se hace cuando existen tres de los cinco factores mencionados. Durante la transición menopáusica hay un rápido incremento en la severidad de este síndrome, lo que provoca un aumento del riesgo cardiovascular. En la obesidad hay un estado proinflamatorio inducido por la mayor producción de citoquinas inflamatorias como TNF-alfa, resistina, leptina, por el adipocito obeso, las cuales están vinculadas con la mayoría de las enfermedades crónicas y con el cáncer. En relación a la hipertensión arterial, hay muchas pacientes que desconocen que son portadoras de esta patología y no se hacen tratar, aumentando su riesgo cardiovascular. Por todo lo anterior, el médico ginecólogo debe de familiarizarse con esta patología y tener una actitud activa al respecto con relación a su diagnóstico y manejo.

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Menopausa e síndrome metabólica

Cited by 43 publications

References 59 publications

Prevalence of metabolic syndrome in pre- and postmenopausal women

Prevalence of metabolic syndrome in pre- and postmenopausal women

The association between gallstone disease and plaque in the abdominopelvic arteries

Síndrome metabólico en el climaterio

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