Antileishmanial effects of Crotalaria spectabilis Roth aqueous extracts on Leishmania amazonensis
JULIANA S. PACHECO,
ÉRIKA MARIA G.F. TEIXEIRA,
RAMON G. PASCHOAL
et al.
Abstract:Fifteen polar extracts from leaf, seed, pod, stem, flower and root of Crotalaria spectabilis were prepared using aqueous systems, based on the principles of green chemistry, and showed different protease inhibitor (PI) activities on trypsin, papain, pepsin and the extracellular L. amazonensis serine protease (LSPIII). The most pronounced inhibitory effect on LSPIII was observed in leaf (CS-P), root, stem, flower (CS-FPVPP) and pod (CS-VA) extracts. Crotalaria extracts exhibited low cytotoxicity on macrophages;… Show more
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