Comparative study on eucalyptol and camphor rich essential oils from rhizomes of Hedychium spicatum Sm. and their pharmacological, antioxidant and antifungal activities

Abstract

The aim of present study was to evaluate chemical composition and different biological activities viz., pharmacological and antioxidant activities of essential oils.The chemical composition of essential oils was determined by gas chromatography/ mass spectrometry while biological activities were evaluated by standard protocols.Essential oils of Hedychium spicatum Sm. from two different ecological niches viz; Nainital (Site-I) and Himachal Pradesh (Site-II) of India revealed the qualitative and quantitative chemo-diversity. Both the oils were dominated by oxygenated terpenoids.Major marker compounds identifi ed were eucalyptol, camphor, linalool, α-eudesmol, 10-epi-γ-eudesmol, and iso-borneol. Both the oils exhibited anti-infl ammatory activity suppressing 17.60 % to 33.57 % infl ammation at 100mg/kg b. wt. dose levels compared to ibuprofen-treated group (40.06 %). The sub-acute infl ammation in oils-treated mice groups (50 and 100 mg/kg b. wt.) increased on day 2 but showed a gradual decrease from day 3 onwards and then recovered to normal by day 10. The antinociception percentage for doses (50 and 100 mg/kg b. wt.) ranged from 33. in Site-II compared to standard drug, ibuprofen (43.08 %). The oils also showed a good antipyretic effect by suppressing Brewer's yeast (Saccharomyces cerevisiae) induced pyrexia after oil dose injection. The oils also exhibited good antioxidant activity.

Is Camphor the Future in Supporting Therapy for Skin Infections?

“…Studies have shown that the EO suppressed 33.57% of inflammation at 100 mg/kg b.wt. dose level, which is comparable to the standard drug ibuprofen (40.06%) [95]. Scientists from Iran tested the analgesic activity of the EO from Artemisia sieberi Besser, which possess 31.2% of camphor.…”

Nanoformulated herbal compounds: enhanced antibacterial efficacy of camphor and thymol-loaded nanogels

“…Additionally, when utilized as the principal component in cedar leaf essential oil, camphor has demonstrated significant inhibition of Candida albicans biofilm formation [ 50 ]. Moreover, within the context of Hedychium spicatum , camphor has been associated with potent antifungal effects against several phytopathogenic fungi, including Sclerotinia sclerotiorum, Rhizoctonia solani, Sclerotium rolfsii, and Colletotrichum falcatum [ 51 ]. Despite these remarkable observations, the precise mechanistic underpinnings governing camphor’s antibacterial activity remain partially understood.…”

Disclosing the Functional Potency of Three Oxygenated Monoterpenes in Combating Microbial Pathogenesis: From Targeting Virulence Factors to Chicken Meat Preservation

“…Linalool (L), eucalyptol (E), and camphor (C) are natural compounds largely found and derived from a variety of plants such as those of the Lauraceae and Lamiaceae botanical families [ 5 , 6 ]. These valuable compounds are classified as generally recognized as safe by the Food and Drug Administration (FDA) and commonly utilized as value-added ingredients for nutraceutical, pharmaceutical, and cosmeceutical purposes owing to their various beneficial properties, including their antibacterial, antioxidant, antifungal, anti-inflammatory, and many other health-promoting activities [ 7 ]. However, it should be noted that the difference between safety and toxicity is tightly related to the administrated dose (i.e., it is dose-dependent).…”