LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury

Chu, Zhaoming; Lu, You; Qin, Rujie; Dong, Yuefu

doi:10.1590/0001-3765202220210188

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Twenty-three mice antisense genes had more than ten PubMed citations, with the most cited being the Kcnq1ot1 ( Table S5 ). This gene regulates several microRNAs that play essential roles in the cell inflammatory response [ 136 ], cerebral ischemia and reperfusion injury [ 137 ], diabetic cardiomyopathy, and other diseases [ 138 ].…”

Section: Resultsmentioning

confidence: 99%

Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane

Santini

Yoshida

Oliveira

et al. 2022

IJMS

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Initially, natural antisense transcripts (NATs, natRNAs, or asRNAs) were considered repressors; however, their functions in gene regulation are diverse. Positive, negative, or neutral correlations to the cognate gene expression have been noted. Although the first studies were published about 50 years ago, there is still much to be investigated regarding antisense transcripts in plants. A systematic review of scientific publications available in the Web of Science databases was conducted to contextualize how the studying of antisense transcripts has been addressed. Studies were classified considering three categories: “Natural antisense” (208), artificial antisense used in “Genetic Engineering” (797), or “Natural antisense and Genetic Engineering”-related publications (96). A similar string was used for a systematic search in the NCBI Gene database. Of the 1132 antisense sequences found for plants, only 0.8% were cited in PubMed and had antisense information confirmed. This value was the lowest when compared to fungi (2.9%), bacteria (2.3%), and mice (54.1%). Finally, we present an update for the cis-NATs identified in Saccharum spp. Of the 1413 antisense transcripts found in different experiments, 25 showed concordant expressions, 22 were discordant, 1264 did not correlate with the cognate genes, and 102 presented variable results depending on the experiment.

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Section: Resultsmentioning

confidence: 99%

Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane

Santini

Yoshida

Oliveira

et al. 2022

IJMS

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“…Knockdown of lncRNA LEF1-AS1 may attenuate microglia apoptosis and inflammatory injuries after SCI ( Cui et al, 2021 ). LncRNA KCNQ1OT1 may promote microglia apoptosis via the regulation of miR-589-5p/NPTN axis post SCI ( Chu et al, 2022 ). Moreover, knockdown of lncRNA XIST may mitigate microglia apoptosis via miR-27a/Smurf1 axis ( Zhao et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The role of apoptosis in spinal cord injury: a bibliometric analysis from 1994 to 2023

Wang,

Cheng

2024

Front. Cell. Neurosci.

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BackgroundApoptosis after spinal cord injury (SCI) plays a pivotal role in the secondary injury mechanisms, which cause the ultimate neurologic insults. A better understanding of the molecular and cellular basis of apoptosis in SCI allows for improved glial and neuronal survival via the administrations of anti-apoptotic biomarkers. The knowledge structure, development trends, and research hotspots of apoptosis and SCI have not yet been systematically investigated.MethodsArticles and reviews on apoptosis and SCI, published from 1st January 1994 to 1st Oct 2023, were retrieved from the Web of Science™. Bibliometrix in R was used to evaluate annual publications, countries, affiliations, authors, sources, documents, key words, and hot topics.ResultsA total of 3,359 publications in accordance with the criterions were obtained, which exhibited an ascending trend in annual publications. The most productive countries were the USA and China. Journal of Neurotrauma was the most impactive journal; Wenzhou Medical University was the most prolific affiliation; Cuzzocrea S was the most productive and influential author. “Apoptosis,” “spinal-cord-injury,” “expression,” “activation,” and “functional recovery” were the most frequent key words. Additionally, “transplantation,” “mesenchymal stemness-cells,” “therapies,” “activation,” “regeneration,” “repair,” “autophagy,” “exosomes,” “nlrp3 inflammasome,” “neuroinflammation,” and “knockdown” were the latest emerging key words, which may inform the hottest themes.ConclusionsApoptosis after SCI may cause the ultimate neurological damages. Development of novel treatments for secondary SCI mainly depends on a better understanding of apoptosis-related mechanisms in molecular and cellular levels. Such therapeutic interventions involve the application of anti-apoptotic agents, free radical scavengers, as well as anti-inflammatory drugs, which can be targeted to inhibit core events in cellular and molecular injury cascades pathway.

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The role of long noncoding ribonucleic acids in the central nervous system injury

Huang,

Wang,

Botchway

et al. 2023

Mol Cell Biochem

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LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury

Cited by 4 publications

References 26 publications

Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane

Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane

The role of apoptosis in spinal cord injury: a bibliometric analysis from 1994 to 2023

The role of long noncoding ribonucleic acids in the central nervous system injury

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