“…Since the COVID outbreak in December 2019 in Wuhan (Hubei, China), uncountable cases of oral alterations have been attributed to the novel coronavirus, although the real mechanism associated with the pathogenesis of the oral lesions remains poorly understood. Despite vasculitis and the individual's immune-mediated response playing a crucial role in the infl ammatory process (Santana et al 2021), these factors by themselves, do not justify the development of most alterations in the mouth.…”