The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

Miatmoko, Andang; Hariawan, Berlian Sarasitha; Cahyani, Devy Maulidya; Sari, Retno; Dinaryanti, Aristika; Hendrianto, Eryk

doi:10.1590/0001-3765202120201850

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…The cellular uptake assay of β-ionone liposomes. 48 . Each component solution was appropriately mixed in a round bottom flask covered with aluminum foil.…”

Section: Evaluation Of Physical Characteristics Of β-Ionone Liposomesmentioning

confidence: 99%

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

Miatmoko

Asmoro

Azhari

et al. 2023

Sci Rep

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Abstractβ-ionone (ION) is a cyclic terpenoid compound that demonstrates considerable potential for the prevention and treatment of cancer. However, the water solubility of β-ionone is poor and the compound demonstrates low permeability. Liposomes have been reported as increasing both qualities. In this study, the development of β-ionone liposomes was initiated by adding 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) to produce cationic liposomes as a means of enhancing binding to cancer cells. Liposomes composed of β-ionone, HSPC, cholesterol, and DSPE-mPEG2000 were prepared using the thin layer hydration method. Cellular uptake studies were carried out with HeLa cells incubated with β-ionone liposomes for two hours. The results indicated that the addition of DOTAP increased particle size and affected the spectroscopical and thermogram profiles of the liposomes, thereby confirming reduction in liposome crystallinity, while the zeta potential became positive. Moreover, the calcein release profile further showed that additional DOTAP increased both membrane fluidity and cellular uptake in HeLa cells In conclusion, adding DOTAP affected the physicochemical cationic properties of liposome and improved cellular uptake in HeLa cells.

show abstract

“…The cellular uptake assay of β-ionone liposomes. 48 . Each component solution was appropriately mixed in a round bottom flask covered with aluminum foil.…”

Section: Evaluation Of Physical Characteristics Of β-Ionone Liposomesmentioning

confidence: 99%

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

Miatmoko

Asmoro

Azhari

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

Chitosan-enclosed SLN improved SV-induced hepatocellular cell carcinoma death by modulation of IQGAP gene expression, JNK, and HDAC activities

Harisa,

Bakheit,

Alshehri

et al. 2024

Mol Biol Rep

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Current advances in niosomes applications for drug delivery and cancer treatment

Moammeri,

Chegeni,

Sahrayi

et al. 2023

Materials Today Bio

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The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

Cited by 3 publications

References 13 publications

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes

Chitosan-enclosed SLN improved SV-induced hepatocellular cell carcinoma death by modulation of IQGAP gene expression, JNK, and HDAC activities

Current advances in niosomes applications for drug delivery and cancer treatment

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