Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate

Zanuzo, Késia; Guareschi, Zoé Maria; Detogni, Anna Caroliny; Huning, Luiz Pierre; Rodrigues, Patrick Fontes; Porto, Elaine Manoela; Grassiolli, Sabrina; Amorim, João Paulo de Arruda

doi:10.1590/0001-3765202020201097

Cited by 3 publications

(3 citation statements)

References 61 publications

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“…Recent studies have underlined the role that physical exercise and natural bioactive compounds (NBCs) may have separately in the prevention of ED in CKD patients [ 19 , 20 , 21 , 22 ]. Nevertheless, nowadays there are few studies in the literature that investigate the effects induced by the physical exercise associated with NBCs assumption in CKD patients [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease

Grazioli

Romani²,

Marrone³

et al. 2021

Life

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Chronic kidney disease (CKD) represents a world-wide public health problem. Inflammation, endothelial dysfunction (ED) and vascular calcifications are clinical features of CKD patients that increase cardiovascular (CV) mortality. CKD-related CV disease pathogenic mechanisms are not only associated with traditional factors such as arterial hypertension and dyslipidemia, but also with ED, oxidative stress and low-grade inflammation. The typical comorbidities of CKD contribute to reduce the performance and the levels of the physical activity in nephropathic patients compared to healthy subjects. Currently, the effective role of physical activity on ED is still debated, but the available few literature data suggest its positive contribution. Another possible adjuvant treatment of ED in CKD patients is represented by natural bioactive compounds (NBCs). Among these, minor polar compounds of extra virgin olive oil (hydroxytyrosol, tyrosol and oleocanthal), polyphenols, and vitamin D seem to exert a beneficial role on ED in CKD patients. The objective of the review is to evaluate the effectiveness of physical exercise protocols and/or NBCs on ED in CKD patients.

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Section: Introductionmentioning

confidence: 99%

“…Authors conclude that physical exercise associated with vitamin D supplementation can prevent renal injury. Unfortunately, this study was conducted on rats, but it may be interesting to evaluate the same effects on humans [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease

Grazioli

Romani²,

Marrone³

et al. 2021

Life

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“…Vitamin D also appears to aid renal cell growth and differentiation post injury as well as diminishing glomerulosclerosis, renal interstitial fibrosis and proteinuria, suggesting a great importance in the control of chronic kidney disease (Andress, 2007). In Wistar rats, experimental kidney injury induced by monosodium glutamate was successfully reversed in the group of animals supplemented with vitamin D (12 μg/kg/day, 3x/week, from the 21st to the 90th day of life) associated with the practice of swimming for the entire supplementation period (Zanuzo et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Utility of vitamin D serum evaluation and supplementation in dogs and cats’ medical routine: a review

Cruz-Filho

Rocha

Santana

et al. 2022

RSD

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Vitamin D is traditionally known for its role in regulating calcium homeostasis and consequently maintaining bone integrity and health. However, more recently, it has been observed that it has a series of previously unknown non-canonical functions, such as maintenance of immunity and intestinal mucosa integrity. Furthermore, it has been shown to be associated with the progression or perpetuation of several diseases since its serum concentration is reduced during the course of the conditions. Therefore, we sought to investigate, through a literature review, the usefulness of serum vitamin D measurement in dogs and cats as a prognostic factor for different diseases, as well as the possible therapeutic effect of supplementing this vitamin in the correction of those illnesses. Vitamin D is in fact deficient in gastroenteric diseases, such as protein-losing enteropathy, infectious diseases, such as canine leishmaniasis, heart and kidney disease, among others. However, it is necessary to understand more properly about the physiological role of vitamin D in health, so that we can also understand it in disease. There are also too few data reports supporting supplementing this vitamin as main or adjuvant therapy in the treatment of any disease, but evidence points to the usefulness of vitamin D serum measurement as a prognostic predictor for dogs and cats.

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A multifaceted review of monosodium glutamate effects on human health and its natural remedies

Yang,

Gao,

Gong

et al. 2023

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Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate

Cited by 3 publications

References 61 publications

Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease

Impact of Physical Activity and Natural Bioactive Compounds on Endothelial Dysfunction in Chronic Kidney Disease

Utility of vitamin D serum evaluation and supplementation in dogs and cats’ medical routine: a review

A multifaceted review of monosodium glutamate effects on human health and its natural remedies

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