Anti-urolithiatic activity of Salvia hispanica L. seeds in ethylene glycol induced urolithiasis rat’s model

Saleem, Uzma; Ahmad, Najid; Shah, Muhammad Ajmal; Anwar, Fareeha; Ahmad, Bashir

doi:10.1590/0001-3765202020200067

Cited by 10 publications

(9 citation statements)

References 22 publications

(14 reference statements)

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“…This may be due to many factors: firstly, the kidney weight relative to the body weight of urolithiatic rats shows a noticeable increase when compared with control rats. This may be indicating the accumulation of fluid and/or crystal formation in the renal tissues supported by the histological examination and this is in line with the data of Saleem et al (2020). Secondly, excess calcium concentration in urine; as the hypercalciuria is a risk aspect that may enhance nucleation of the renal calculi formation (Pandhare et al, 2021).…”

Section: Discussionsupporting

confidence: 70%

“…Urolithiasis is a hurting ailment generally known as kidney and/or urinary stone that prescribed as the third disorder in the urinary diseases causing a major impact on public health that may progressed to renal calcification (Ahmed et al, 2020;Patel & Acharya, 2020;Saleem et al, 2020). It affects both genders, but according to the survey of National Health and Nutrition Examination men are more susceptible to urolithiasis (Pandhare et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sayed

Soliman

Fahmy

et al. 2023

JoBAZ

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Background The present study assesses the role of polyherbal formula (LACTN) against sodium oxalate (NaOx)—stimulated urolithiasis prophylactic and curative. Forty-eight rats were separated into the following regimen’s groups: Groups I, II, III, and IV (prophylactic groups). Group I (control group) received saline as vehicle. Group II (urolithiatic group) received 70 mg NaOx / kg b.wt, i.p. Groups III and IV received LACTN and cystone prophylactic (500 and 750 mg/kg b.wt, respectively) from 1st day to 7th day of urolithiasis induction. Groups V, VI, VII, and VIII (curative groups): these were divided into the prophylactic regimes, but LACTN and cystone were administered from 7th day to 14th day of urolithiasis induction. Results Urolithiatic rats co-/post-treated with LACTN and cystone elevated the urinary volume significantly (P < 0.05). Also, a significant decrease (P < 0.05) was observed in the serum and urine calcium and phosphate concentrations beside the increased magnesium value in urolithiatic rats co-/post-treated with LACTN. LACTN significantly (P < 0.05) ameliorates serum and urine creatinine, urea, and uric acid concentration. Moreover, urolithiatic rats co-/post-treated with LACTN significantly (P < 0.05) diminished MDA and increased GSH, GST, SOD, and CAT compared with urolithiatic rats. Conclusions LACTN has anti-lithogenesis effect that may be due to its ability to remove the already presenting stone and/or to prevent the generation of extra calcium oxalate crystals. This action may be due to its components’ synergetic action that may provide encouraging combined formula to prevent/treat urolithiasis.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Sayed

Soliman

Fahmy

et al. 2023

JoBAZ

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“…At the same time, the in vitro experimental results showed that the extract of CS can inhibit the initial formation of calcium oxalate stones, and also has an inhibitory effect on subsequent maturation, aggregation, and stone growth. 80 The versatility of CS is also reflected in its reversal of ovarian dysfunction induced by a high-fat diet. Compared with the negative model rats, CS supplementation significantly improved the serum hormone profile of the test rats, upregulated levels of follicle stimulating hormone, serum luteinizing hormone, and progesterone, and decreased the content of estradiol.…”

Section: Bowel Health Improvement and Other Functionsmentioning

confidence: 99%

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

Chen,

Wu,

Zhu

et al. 2024

Food Funct.

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“…In vitro studies showed that chia seed extract prevented calcium oxalate stone formation by inhibiting the initial stages of CaOx crystal formation, including nucleation, aggregation, and growth phases. The authors suggested that flavonoids present in chia seeds are responsible for this activity, mainly quercetin, which through its antioxidant potential prevents the precipitation of kidney stones [36,[93][94][95] (Table 5).…”

Section: Action Against Kidney Stonesmentioning

confidence: 99%

“…Chia seeds, as a valuable and increasingly popular component of "healthy food", have been the focus of previously published review articles [6,9,[31][32][33][34][35][36][37][38][39]. The authors emphasized the importance of chia seeds as a valuable new food resource with high health and antioxidant potential.…”

Section: Introductionmentioning

confidence: 99%

The Current State of Knowledge on Salvia hispanica and Salviae hispanicae semen (Chia Seeds)

et al. 2022

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Chia seeds (Salviae hispanicae semen) are obtained from Salvia hispanica L. This raw material is distinguished by its rich chemical composition and valuable nutritional properties. It is currently referred to as “health food”. The purpose of the present work was to perform a literature review on S. hispanica and chia seeds, focusing on their chemical composition, biological properties, dietary importance, and medicinal uses. The valuable biological properties of chia seeds are related to their rich chemical composition, with particularly high content of polyunsaturated fatty acids, essential amino acids, polyphenols, as well as vitamins and bioelements. The available scientific literature indicates the cardioprotective, hypotensive, antidiabetic, and antiatherosclerotic effects of this raw material. In addition, studies based on in vitro assays and animal and human models have proven that chia seeds are characterized by neuroprotective, hepatoprotective, anti-inflammatory, and antioxidant properties. These properties indicate a valuable role of chia in the prevention of civilization diseases. Chia seeds are increasingly popular in functional food and cosmetic and pharmaceutical industries. That is attributed not only to their desirable chemical composition and biological activity but also to their high availability. Nevertheless, S. hispanica is also the object of specific biotechnological studies aimed at elaboration of micropropagation protocols of this plant species.

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Anti-urolithiatic activity of Salvia hispanica L. seeds in ethylene glycol induced urolithiasis rat’s model

Cited by 10 publications

References 22 publications

Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

Antiurolithiatic effect of a polyherbal formulation against sodium oxalate-induced urolithiasis in rats

A review of the functional activities of chia seed and the mechanisms of action related to molecular targets

The Current State of Knowledge on Salvia hispanica and Salviae hispanicae semen (Chia Seeds)

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