Plasma miR-1273g-3p acts as a potential biomarker for early Breast Ductal Cancer diagnosis

Abstract

Circulating miRNAs presenting in plasma in a stable manner have been demonstrated their potential role as a promising biomarkers in many human diseases, such as Alzheimer's disease, melanoma and ovarian carcinoma. However, few circulating miRNAs could be used for breast ductal cancer diagnosis. Here, we identified miR-1273g-3p as a biomarker for detecting breast ductal cancer. We detected miR-1273g-3p levels in the plasma of 39 sporadic breast ductal cancer patients and 40 healthy donors by Stemloop Quantitative Real-time PCR (qRT-PCR). The results showed the plasma miR-1273g-3p level were significantly up-regulated in breast ductal cancer patients compared with healthy donors (p=0.0139). Receiver operating characteristic (ROC) curve also revealed the significantly diagnostic ability of miR-1273g-3p in patients (p=0.0414). In addition, the plasma level of miR-1273g-3p was closely related to IIIB-IIIC TNM stage. We also confirmed the higher expression level of miR-1273g-3p in breast cancer cell lines MCF-7 (4.872±0.537) than normal breast cells (Hs 578Bst). Taken together, miR-1273g-3p could represent as a potential biomarker for early breast ductal cancer diagnosis.

A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research

“…miR-1273 g has been linked to breast cancer [ 138 , 139 ] and radiation treatments of cancer [ 140 ]. However, no clinical studies have reported a link with cardiovascular diseases and therefore, this microRNA is not currently considered informative for cardiotoxicity in breast cancer patients.…”

Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review

“…In total, 16 142 articles were identified in the aforementioned databases (Table 1). However, 234 articles were retained for full reading, following the elimination of duplicates and articles whose title and abstract did not meet the eligibility criteria; of these, only 136 12…”

Breast Invasive Ductal Carcinoma Diagnosis with A Three-Mirna Panel in Serum

“…miRNAs have gained increasing relevance because of their functions in the growth of cancer cells such as hyperplasia and migration [8]. In recent years, several studies including the research of Papachristopoulou et al [13] and Guo et al [14] illuminated the potential relationship between miRNA and breast tumors, while their researches only clarify the role of one particular miRNA in breast neoplasms. For other correlative studies, they paid more attention on the relationship between clinicopathological characteristics and miRNAs [15,16].…”