Is the brazilian diverse environment is a crib for the emergence and maintenance of exotic arboviruses?

Medeiros, Daniele Barbosa de Almeida; Vasconcelos, Pedro Fernando da Costa

doi:10.1590/0001-3765201920190407

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…The recent Zika virus epidemic and the spread of dengue, chikungunya and yellow fever cases are just a few examples of diseases that affect countries in the Amazon region and even other regions of the globe (Ellwanger & Chies 2016, Lima-Camara 2016, Schuler-Faccini et al 2016, Donalisio et al 2017, Goldani 2017, Gregianini et al 2017. Amazonian fauna hosts a huge diversity of well-known pathogens, as well as many other potential new or even unknown pathogens (Vasconcelos et al 2001, Abrahão et al 2010, Dornas et al 2014, Bonato et al 2015, Soares et al 2015, Barros et al 2018, da Silva et al 2018, Fernandes et al 2018, Farikoski et al 2019, Franco Filho et al 2019, Medeiros & Vasconcelos 2019. Although several of these pathogens may have low epidemic potential in humans, this abundance of microorganisms in the Amazon region indicates that emergence of new infections from the forest is a constant threat to human health.…”

Section: Introductionmentioning

confidence: 99%

Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health

Ellwanger

Kulmann-Leal

Kaminski

et al. 2020

An. Acad. Bras. Ciênc.

192

109

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Amazonian biodiversity is increasingly threatened due to the weakening of policies for combating deforestation, especially in Brazil. Loss of animal and plant species, many not yet known to science, is just one among many negative consequences of Amazon deforestation. Deforestation affects indigenous communities, riverside as well as urban populations, and even planetary health. Amazonia has a prominent role in regulating the Earth's climate, with forest loss contributing to rising regional and global temperatures and intensification of extreme weather events. These climatic conditions are important drivers of emerging infectious diseases, and activities associated with deforestation contribute to the spread of disease vectors. This review presents the main impacts of Amazon deforestation on infectious-disease dynamics and public health from a One Health perspective. Because Brazil holds the largest area of Amazon rainforest, emphasis is given to the Brazilian scenario. Finally, potential solutions to mitigate deforestation and emerging infectious diseases are presented from the perspectives of researchers in different fields.

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Section: Introductionmentioning

confidence: 99%

Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health

Ellwanger

Kulmann-Leal

Kaminski

et al. 2020

An. Acad. Bras. Ciênc.

192

109

View full text Add to dashboard Cite

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“…Amazonian fauna hosts a vast diversity of well-known pathogens and many other potential new or even unknown pathogens ( 6 – 11 ). This abundance of microorganisms indicates that the emergence of new infections from the forest is a constant threat to human health, particularly favorable to water-borne diseases due to anthropogenic activities nearby freshwater sources, such as ponds, rivers, basins, and lakes ( 12 – 14 ).…”

Section: Introductionmentioning

confidence: 99%

Viral Metagenomics Reveals Widely Diverse Viral Community of Freshwater Amazonian Lake

Nogueira

Gois

Pinheiro

et al. 2022

Front. Public Health

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Despite the importance of understanding the ecology of freshwater viruses, there are not many studies on the subject compared to marine viruses. The microbiological interactions in these environments are still poorly known, especially between bacteriophages and their host bacteria and between cyanophages and cyanobacteria. Lake Bologna, Belém, capital of the Brazilian State of Pará, is a water source that supplies the city and its metropolitan region. However, it remains unexplored regarding the contents of its virome and viral diversity composition. Therefore, this work aims to explore the taxonomic diversity of DNA viruses in this lake, especially bacteriophages and cyanophages, since they can act as transducers of resistance genes and reporters of water quality for human consumption. We used metagenomic sequencing data generated by previous studies. We analyzed it at the taxonomic level using the tools Kraken2, Bracken, and Pavian; later, the data was assembled using Genome Detective, which performs the assembly of viruses. The results observed here suggest the existence of a widely diverse viral community and established microbial phage-regulated dynamics in Lake Bolonha. This work is the first ever to describe the virome of Lake Bolonha using a metagenomic approach based on high-throughput sequencing, as it contributes to the understanding of water-related public health concerns regarding the spreading of antibiotic resistance genes and population control of native bacteria and cyanobacteria.

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“…As many of them are the etiological agents of relevant human pathologies, they pose a special threat in vulnerable countries around the world. Tropical countries of South America, such as Brazil, are specially in risk for arboviruses outbreaks due to the suitable warm weather, abundance of insect vectors, deforestation, high population concentration near forest areas, social-economical disparities, and overburden of the public healthcare system (Peña-Garcıá et al, 2017;Figueiredo, 2019;Medeiros and Vasconcelos, 2019). Many endemic outbreaks along the history, as well the recent introduction of arboviruses in Brazil, have risen the alarm of scientific and medical communities concerning the risk of new outbreaks, co-circulation of those viruses, and increasing of more severe cases (Metsky et al, 2017;Zanotto and Leite, 2018;Lorenz et al, 2019;Gutierrez et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

Geddes

Brustolini

Cavalcante

et al. 2021

Front. Cell. Infect. Microbiol.

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Arboviruses pose a major threat throughout the world and represent a great burden in tropical countries of South America. Although generally associated with moderate febrile illness, in more severe cases they can lead to neurological outcomes, such as encephalitis, Guillain-Barré syndrome, and Congenital Syndromes. In this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. Here, we presented a comprehensive genome-wide transcriptome analysis of human primary astrocytes infected with Chikungunya, Mayaro, Oropouche, or Zika viruses. Analyses of differentially expressed genes (DEGs), pathway enrichment, and interactomes have shown that Alphaviruses up-regulated genes related to elastic fiber formation and N-glycosylation of glycoproteins, with down-regulation of cell cycle and DNA stability and chromosome maintenance genes. In contrast, Oropouche virus up-regulated cell cycle and DNA maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. Zika virus infection only up-regulated eukaryotic translation machinery while down-regulated interferon pathways. Reactome and integration analysis revealed a common signature in down-regulation of innate immune response, antiviral response, and inflammatory cytokines associated to interferon pathway for all arboviruses tested. Validation of interferon stimulated genes by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) corroborated our transcriptome findings. Altogether, our results showed a co-evolution in the mechanisms involved in the escape of arboviruses to antiviral immune response mediated by the interferon (IFN) pathway.

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Is the brazilian diverse environment is a crib for the emergence and maintenance of exotic arboviruses?

Abstract: How to cite: medeIROS dBA ANd VASCONCelOS PFC. 2019. Is the brazilian diverse environment is a crib for the emergence and maintenance of exotic arboviruses? An Acad Bras Cienc 91: e20190407.

Cited by 6 publications

References 21 publications

Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health

Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health

Viral Metagenomics Reveals Widely Diverse Viral Community of Freshwater Amazonian Lake

Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses

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