Dietary iron chelate for sows and effects on iron supplementation in piglets

Barros, Carine Araújo; Pascoal, Leonardo Augusto Fonseca; Watanabe, Pedro Henrique; Martins, Terezinha Domiciano Dantas; Andrade, Tiago Silva; Ribeiro, José E S

doi:10.1590/0001-3765201920180509

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…Generally, the neonatal piglets used the strategy of extra iron injection to satisfy the iron requirement for piglet growth, while after weaning, dietary iron supplementation is a common way to prevent iron deficiency in weaned piglets ( 20 , 21 ). In the current study, dietary FGC supplementation improved the ADG of piglets from day 0–7, day 15–28, and overall alleviated diarrhea in the pre-piglet period, which was consistent with the previous findings ( 22 , 23 ). There are some reasons for this result.…”

Section: Discussionsupporting

confidence: 93%

Dietary Supplementation of Ferrous Glycine Chelate Improves Growth Performance of Piglets by Enhancing Serum Immune Antioxidant Properties, Modulating Microbial Structure and Its Metabolic Function in the Early Stage

Liu

Piao

et al. 2022

Front. Vet. Sci.

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The present research aimed to explore the effect of dietary ferrous glycine chelate supplementation on performance, serum immune-antioxidant parameters, fecal volatile fatty acids, and microbiota in weaned piglets. A total of 80 healthy piglets (weaned at 28 day with an initial weight of 7.43 ± 1.51 kg) were separated into two treatments with five replicates of eight pigs each following a completely randomized block design. The diet was a corn-soybean basal diet with 2,000 mg/kg ferrous glycine chelates (FGC) or not (Ctrl). The serum and fecal samples were collected on days 14 and 28 of the experiment. The results indicated that dietary FGC supplementation improved (p < 0.05) the average daily gain and average daily feed intake overall, alleviated (p < 0.05) the diarrhea rate of piglets at the early stage, enhanced (p < 0.05) the levels of superoxide dismutase and catalase on day 14 and lowered (p < 0.05) the MDA level overall. Similarly, the levels of growth hormone and serum iron were increased (p < 0.05) in the FGC group. Moreover, dietary FGC supplementation was capable of modulating the microbial community structure of piglets in the early period, increasing (p < 0.05) the abundance of short-chain fatty acid-producing bacteria Tezzerella, decreasing (p < 0.05) the abundance of potentially pathogenic bacteria Slackia, Olsenella, and Prevotella as well as stimulating (p < 0.05) the propanoate and butanoate metabolisms. Briefly, dietary supplemented FGC ameliorates the performance and alleviated the diarrhea of piglets by enhancing antioxidant properties, improving iron transport, up-regulating the growth hormone, modulating the fecal microbiota, and increasing the metabolism function. Therefore, FGC is effective for early iron supplementation and growth of piglets and may be more effective in neonatal piglets.

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Section: Discussionsupporting

confidence: 93%

Dietary Supplementation of Ferrous Glycine Chelate Improves Growth Performance of Piglets by Enhancing Serum Immune Antioxidant Properties, Modulating Microbial Structure and Its Metabolic Function in the Early Stage

Liu

Piao

et al. 2022

Front. Vet. Sci.

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“…Iron application during the strongest fetal growth period in late pregnancy could improve the neonatal weight of piglets [36,37] . Previous studies showed that maternal supplementation with organic iron could improve the litter weight of piglets [38] , or increase growth performance of piglets [39] . Our research found that EP-Fe could not contribute to improving the litter size, litter weight and live litter rate of sows at 95 days of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Effects of maternal dietary enteromorpha prolifera polysaccharide iron supplement on mineral elements and iron level of neonatal piglets

Liu

Wang³

et al. 2023

Preprint

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Iron plays a key role in maternal health during pregnancy and fetal growth. Enteromorpha polysaccharide –iron (EP-Fe) as an organic iron chelate may improve the iron transmission of mother and offspring, ameliorate the poor pregnancy outcomes of sows, and alleviate the growth restriction of piglets caused by iron deficiency. This study aimed to evaluate the effects of maternal dietary supplementation with EP-Fe on reproductive performance and placental iron transmission of sows, as well as growth performance of piglets. Sixty pregnant sows at the 95th day of gestation were randomly divided into control group (CON) and EP-Fe group (EP-Fe, 139 mg kg− 1). Blood samples of sows and neonatal piglets, colostrum, and tissue samples were collected on the day of delivery. The animal experiment ended at the 21th day of post-delivery. Results showed that maternal dietary EP-Fe increased colostrum iron (P < 0.05) of sows, as well as final litter weight (P < 0.05) and average daily weight of piglets (P < 0.05) during d 1–21 of lactation, as well as iron and manganese content in umbilical cord blood (P < 0.05) and hepatic iron of neonatal piglets (P < 0.01), and decreased fecal iron (P < 0.001), serum calcium (P < 0.05), phosphorus (P < 0.05) and zinc (P < 0.01) in the parturient sow. RT-qPCR results showed that FPN1 and SLC39A14 in placenta, as well as TfR1 and SLC39A14 in duodenum of neonatal piglets were activated by maternal EP-Fe supplement. These findings suggest that maternal dietary EP-Fe could increase iron storage of neonatal piglets via improving placental iron transport and iron secretion in colostrum, thus enhance the growth performance of sucking piglets.

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“…However, this treatment is highly challenging considering its possible adverse effects on sow's iron metabolism, the risk of iron toxicity and insufficiency of the molecular machinery involved in transplacental iron transport. Indeed, supplementation of sows at various stages of pregnancy, using various iron supplements (iron salts/chelates, iron dextran) administered orally or parenterally has no significant impact on the improvement of iron status of newly born piglets and has not been proven in prophylaxis of neonatal IDA in piglets [16,[19][20][21][67][68][69][70][71][72]. Despite these negative results, in this study we attempted to test the efficacy of prenatal oral supplementation with SFP through administration of this compound to pregnant sows.…”

Section: Discussionmentioning

confidence: 99%

“…However, while in preterm human neonates the shortage of stored iron results from shortened period of iron deposition in the fetal liver, in term newborn piglets the main reason is the physiological inability of pregnant sow to meet iron demand for the greater number of fetuses. Several studies have attempted to increase the level of iron hepatic iron stores in fetuses by treating pregnant sows with iron supplements [16][17][18][19][20][21][22]. However, supplementation of sows at various stages of pregnancy, using various iron supplements administered orally or parenterally has no significant impact on the improvement of the iron status of newborn piglets and thus does not prevent suckling animals from becoming anemic (reviewed in Reference [23]).…”

Section: Introductionmentioning

confidence: 99%

Effect of Oral Supplementation of Healthy Pregnant Sows with Sucrosomial Ferric Pyrophosphate on Maternal Iron Status and Hepatic Iron Stores in Newborn Piglets

Mazgaj

Szudzik

Lipiński

et al. 2020

Animals

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Background: The similarities between swine and humans in physiological and genomic patterns, as well as significant correlation in size and anatomy, make pigs an useful animal model in nutritional studies during pregnancy. In humans and pigs iron needs exponentially increase during the last trimester of pregnancy, mainly due to increased red blood cell mass. Insufficient iron supply during gestation may be responsible for the occurrence of maternal iron deficiency anemia and decreased iron status in neonates. On the other hand, preventive iron supplementation of non-anemic mothers may be of potential risk due to iron toxicity. Several different regimens of iron supplementation have been applied during pregnancy. The majority of oral iron supplementations routinely applied to pregnant sows provide inorganic, non-heme iron compounds, which exhibit low bioavailability and intestinal side effects. The aim of this study was to check, using pig as an animal model, the effect of sucrosomial ferric pyrophosphate (SFP), a new non-heme iron formulation on maternal and neonate iron and hematological status, placental transport and pregnancy outcome; Methods: Fifteen non-anemic pregnant sows were recruited to the experiment at day 80 of pregnancy and randomized into the non-supplemented group (control; n = 5) and two groups receiving oral iron supplementation—sows given sucrosomial ferric pyrophosphate, 60 mg Fe/day (SFP; n = 5) (SiderAL®, Pisa, Italy) and sows given ferrous sulfate 60 mg Fe/day (Gambit, Kutno, Poland) (FeSO4; n = 5) up to delivery (around day 117). Biological samples were collected from maternal and piglet blood, placenta and piglet tissues. In addition, data on pregnancy outcome were recorded.; Results: Results of our study show that both iron supplements do not alter neither systemic iron homeostasis in pregnant sows nor their hematological status at the end of pregnancy. Moreover, we did not detect any changes of iron content in the milk and colostrum of iron supplemented sows in comparison to controls. Neonatal iron status of piglets from iron supplemented sows was not improved compared with the progeny of control females. No statistically significant differences were found in average piglets weight and number of piglets per litter between animals from experimental groups. The placental expression of iron transporters varied depending on the iron supplement.

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Dietary iron chelate for sows and effects on iron supplementation in piglets

Cited by 7 publications

References 19 publications

Dietary Supplementation of Ferrous Glycine Chelate Improves Growth Performance of Piglets by Enhancing Serum Immune Antioxidant Properties, Modulating Microbial Structure and Its Metabolic Function in the Early Stage

Dietary Supplementation of Ferrous Glycine Chelate Improves Growth Performance of Piglets by Enhancing Serum Immune Antioxidant Properties, Modulating Microbial Structure and Its Metabolic Function in the Early Stage

Effects of maternal dietary enteromorpha prolifera polysaccharide iron supplement on mineral elements and iron level of neonatal piglets

Effect of Oral Supplementation of Healthy Pregnant Sows with Sucrosomial Ferric Pyrophosphate on Maternal Iron Status and Hepatic Iron Stores in Newborn Piglets

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