The Ornate Moth,
Utetheisa ornatrix
, has served as a model species in chemical ecology studies for decades. Like in the widely publicized stories of the Monarch and other milkweed butterflies, the Ornate Moth and its relatives are tropical insects colonizing whole continents assisted by their chemical defenses. With the recent advances in genomic techniques and evo-devo research, it is becoming a model for studies in other areas, from wing pattern development to phylogeography, from toxicology to epigenetics. We used a genomic approach to learn about
Utetheisa’s
evolution, detoxification, dispersal abilities, and wing pattern diversity. We present an evolutionary genomic analysis of the worldwide genus
Utetheisa
, then focusing on
U. ornatrix
. Our reference genome of
U. ornatrix
reveals gene duplications in the regions possibly associated with detoxification abilities, which allows them to feed on toxic food plants. Finally, comparative genomic analysis of over 100
U. ornatrix
specimens from the museum with apparent differences in wing patterns suggest the potential roles of
cortex
and
lim3
genes in wing pattern formation of Lepidoptera and the utility of museum-preserved collection specimens for wing pattern research.