Evaluation in vivo of biocompatibility of differents resin-modified cements for bonding orthodontic bands

Mesquita, Janaina Almeida; Santos, Rogério Lacerda dos; Sampaio, Gêisa A.M.; Godoy, Gustavo Pina; Nonaka, Cassiano Francisco Weege; Alves, Pollianna Muniz

doi:10.1590/0001-3765201720170329

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…Initially, the rats were anesthetized with an intraperitoneal injection of sodium thiopental (50mg/kg) (Cristália, SP, Brazil). Trichotomy was performed in the dorsal region of each animal, and for antisepsis, 4% chlorhexidine digluconate was used (12,13). On the midline, equidistant from the insertion of the animal's tale and head, two incisions approximately 8 mm long by 18 mm deep were made.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial, mechanical and biocompatibility analysis of chlorhexidine digluconate-modified cements

Sampaio¹,

Meneses²,

Carvalho³

et al. 2020

J Clin Exp Dent

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Background: The focus of this study was to evaluate the antimicrobial, mechanical properties and biocompatibility of glass ionomer (GICs) modified by Chlorhexidine (CHX). Material and Methods: For biocompatibility, 105 male Wistar rats were used, divided into 7 groups (n=15): Group C (Control,Polyethylene), Groups M, M10, M18, and Groups RL, RL10, RL18 (M-Meron and RL-Riva Luting: conventional, and modified with 10%, and 18% CHX, respectively). The tissues were analyzed under optical microscope for different cellular events and time intervals. Antibacterial effect and Shear Bond Strength Test (SBST) were also analyzed. Biocompatibility was analyzed by the Kruskal-Wallis and Dunn tests; SBST one-way ANOVA and Tukey test (P<0.05). For the antibacterial effect, the Kruskal-Wallis and Friedman, followed by Dunn (P<0.05) tests were used. Results: Morphological study of the tissues showed inflammatory infiltrate with significant differences between Groups C and RL18, in the time intervals of 7(P=0.013) and 15(P=0.032) days. The antimicrobial effects of the cements was shown to be CHX concentration-dependent (P=0.001). The SBST showed no significant difference between the Groups of Meron cement (P=0.385), however, there was difference between Group RL and Groups RL10 and RL18 (P=0.001). Conclusions: The addition of CHX did not negatively influence the SBST. Meron-CHX-10% was the most biocompatible, and Riva-CHX-18% had more influence on the inflammatory process and presented slower tissue repair.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial, mechanical and biocompatibility analysis of chlorhexidine digluconate-modified cements

Sampaio¹,

Meneses²,

Carvalho³

et al. 2020

J Clin Exp Dent

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“…31 The first biocompatibility analysis was performed after 7 days, as it is only after this period that a more organized inflammatory reaction can be expected. 32 Intense inflammatory infiltrate was demonstrated only in the cements with 10% EEP in the time intervals of 7 and 15 days (p = 0.01). The intensity of the inflammatory infiltrate was shown to be inversely proportional to the experimental time intervals and concentration of propolis; however, a persistent, chronic infiltrate was exhibited in the Ketac cement 10% EEP (p = 0.01) at 30 days.…”

Section: Discussionmentioning

confidence: 91%

Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis

et al. 2021

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Objective The focus of this study was to evaluate the biocompatibility of ionomer cements modified with ethanolic extracts of propolis (EEP) in different concentrations and time intervals. Materials and Methods In total, one hundred and thirty-five male Wistar rats were randomized into nine groups: Control, Groups Meron, and Groups Ketac (conventional, and added with 10, 25, 50% EEP, respectively). Histological analyses of inflammatory infiltrate and collagen fibers, and immunohistochemistry of CD68+ for macrophages (MOs) and multinucleated giant cells (MGCs) were performed. Statistical Analysis Data were analyzed using the Kruskal—Wallis and Dunn (p < 0.05) tests. Results Intense inflammatory infiltrate was demonstrated in the cements with 10% EEP at 7 days and 15 days (p < 0.05), only Group Ketac 10% EEP (p = 0.01) at 30 days. A smaller quantity of collagen fibers was observed in the cements with 10% EEP (p = 0.01) at 7 days, and Group Meron 10% EEP (p = 0.04) at 15 days. MOs and MGCs showed significant difference for the cements with 10% EEP (p = 0.01) at 7 and 15 days. At 30 days, MOs persisted in the Groups with 10% EEP. Conclusions The concentration of 10% EEP had the greatest influence on the inflammatory and tissue repair processes. The concentrations of 25 and 50% EEP demonstrated biocompatibility similar to that of cements that did not receive EEP.

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“…The animals were placed in EB 273C (Insight Ltd, Sao Paulo, Brazil) vivarium cabinets, with temperature control at 23 ± 1°C, 41% humidity, and were fed, during the entire period of the experiment, a solid diet of animal ration and water “ ad libitum .” 17 18 19 …”

Section: Methodsmentioning

confidence: 99%

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

et al. 2021

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Objective The objective of this study was to evaluate the hemostatic activity of the sap from Jatropha mollissima (Pohl) Baill. in rats. Materials and Methods Twenty-four Wistar rats were randomized into four groups (n = 6): the JM25 and JM40 groups were treated with ethanolic extract from the sap of J. mollissima, in a concentration of 25 and 40 mg·mL1, respectively; the MO group was treated with Monsel’s solution and the control group SC with a 0.9% sodium chloride solution. Statistical Analysis Data were submitted to the Kurskal–Wallis’ test, followed by Dunn’s post hoc (p < 0.05). Results There was a significant reduction in the bleeding time of the group from the JM25 extract (p = 0.001) when compared with MO and SC. There were no statistically significant differences between groups JM25 and JM40 (p > 0.05). The JM25 group did not present rebleeding, a result significantly different from the MO group (p = 0.001). Monsel’s solution showed significant bleeding, six times greater than the control group SC. Conclusion The J. mollissima extract, in the concentration of 25 mg·mL1, showed the highest hemostatic efficiency and was found to be a promising biomaterial for the elaboration of a hemostatic product.

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Evaluation in vivo of biocompatibility of differents resin-modified cements for bonding orthodontic bands

Cited by 7 publications

References 23 publications

Antimicrobial, mechanical and biocompatibility analysis of chlorhexidine digluconate-modified cements

Antimicrobial, mechanical and biocompatibility analysis of chlorhexidine digluconate-modified cements

Effect of Yellow Propolis on Biocompatibility of Cements: Morphological and Immunohistochemistry Analysis

In vivo Hemostatic Activity of Jatropha mollissima: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model

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