Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)

Abstract

Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotective and hypoglycemiant effects of raw extract, fractions and compounds from leaves of M. hirsuta. The cytogenotoxic effects of ursolic and oleanolic acids, the main phytotherapic components of this plant, were assessed. The raw extract and fractions presented steroids, saponins, flavonols, flavanonols, flavanones, xanthones, phenols, tannins, anthocyanins, anthocyanidins and flavonoids. The ethyl acetate fraction inhibited efficiently the cascade of lipid peroxidation while the hydroalcoholic fraction was richer in total phenols and more efficient in capturing 2,2-diphenyl-1-picrylhydrazyl ( · DPPH) and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS ·+ ) radicals. The isolated fraction of M. hirsuta also inhibited the α-amylase activity. Cytotoxic effects were absent in both raw extract and fractions while ursolic+oleanolic acids were efficient in protecting cells after exposure to hydrogen peroxide. Moreover, this mixture of acid shad no significant interference on the mitotic index and frequency of nuclear and/ or chromosomal abnormalities in Allium cepa test. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and oxidative pathologies, including diabetes.

Health benefits of chocolate consumption with high concentration of cocoa incorporated from triterpenic acids, isolated from Mansoa Hirsuta DC.

“…These are known to possess anticholesterolemic, hypoglycemic, anti-hepatotoxic, antioxidant, anti-inflammatory, antifungal and antibiotic activity. Also, they are said to inhibit the growth of tumors and pathogens (Pereira et al, 2017;Zhang et al, 2019).…”

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

“…Some biological activities have been reported for this species, which include inhibition of tumor necrosis factor alpha (TNF-α) and cyclooxygenase-1 [19,20] as well as anti-hypertensive [21], antifungal [22], and antioxidant activities [18]. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and others pathologies [18].…”

“…The raw ethanol extract and fractions from M. hirsuta contains many active components que have a wide spectrum of biological and pharmacological activities. Such components include phenols, tannins, steroids, triterpenes, saponins, flavonols, flavanonols, flavanones, xanthones, anthocyanins, anthocyanidins, and flavonoids [ 18 ]. Some biological activities have been reported for this species, which include inhibition of tumor necrosis factor alpha (TNF-α) and cyclooxygenase-1 [ 19 , 20 ] as well as anti-hypertensive [ 21 ], antifungal [ 22 ], and antioxidant activities [ 18 ].…”

“…Such components include phenols, tannins, steroids, triterpenes, saponins, flavonols, flavanonols, flavanones, xanthones, anthocyanins, anthocyanidins, and flavonoids [ 18 ]. Some biological activities have been reported for this species, which include inhibition of tumor necrosis factor alpha (TNF-α) and cyclooxygenase-1 [ 19 , 20 ] as well as anti-hypertensive [ 21 ], antifungal [ 22 ], and antioxidant activities [ 18 ]. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and others pathologies [ 18 ].…”

Caracterização E Qualidade De Frutos De Cajarana (Spondias Dulcis Parkinson) Provenientes Do Oeste Da Bahia

“…Do mesmo modo, a utilização de alimentos naturais que contenham ácido oleanólico ou ácido ursólico, triterpenos amplamente distribuídos no reino vegetal, na medicina popular édiversa e muito antiga, eles são conhecidos por possuírem atividade anticolesterolêmica, hipoglicemiante, anti-hepatotóxica, antioxidante, antiinflamatória, antifúngica, antibiótica, inibe o crescimento de tumores e de patógenos (Shanmugam et al, 2013;Pereira et al, 2017).…”