Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables

Monsalve, Bernardita; Concha-Meyer, Aníbal; Palomo, Iván; Fuentes, Eduardo

doi:10.1590/0001-3765201720160509

Cited by 29 publications

(10 citation statements)

References 162 publications

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“…According to the World Health Organization (WHO), cardiovascular diseases (CVDs) are the main cause of death in the world and represent 31% of all global deaths (WHO, ). Several molecules found in fruits and vegetables could provide cardioprotection and reduce the risk of CVD (Monsalve, Concha‐Meyer, Palomo, & Fuentes, ; Petyaev, ). Lycopene is a carotenoid that can be found at high levels in tomatoes or tomato‐containing products (Costa‐Rodrigues, Pinho, & Monteiro, ).…”

Section: Introductionmentioning

confidence: 99%

Consumer Response to Tomato Pomace Powder as an Ingredient in Bread: Impact of Sensory Liking and Benefit Information on Purchase Intent

Concha-Meyer

Durham

Colonna

et al. 2019

Journal of Food Science

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This study evaluated consumer acceptance and purchase intent (PI) for bread formulated with dried tomato pomace powder (DTPP). DTPP was used to substitute 5 or 10% by weight for a 50/50 mix of white and whole-wheat flour used in a control bread. Consumers (n = 231) evaluated sensory attributes and PI on the breads, which were produced and presented as slices from a typical commercial sandwich loaf. Before answering PI questions, panelists were presented with information regarding the DTPP ingredient. Some received information on nutritional quality, some on sustainability impact, some both, some neither. This approach allowed the impacts of those messages on PI to be tested, along with impact of liking, price, and other factors. PI was analyzed using a fractional logistic model. Statistically significant differences were observed in several sensory attributes, some favoring the DTPP ingredient with overall liking very similar for the 5% DTPP and control bread samples. Price and overall liking were highly significant variables effecting PI. DTPP proved to be an excellent ingredient to replace a portion of wheat flours to improve nutritional value of bread products.Practical Application: This study shows that dried tomato pomace powder (DTPP) has potential application as an ingredient, since it improved nutritional content, appearance, and color appeal of wheat bread. Furthermore, food producers who are considering the use of byproducts in their product formulations should be encouraged by the finding that informed consumers were as willing to purchase the bread with the ingredient, as they were to purchase a typical comparable sandwich bread without it. Furthermore, both a nutrition message and a sustainability message can increase PI for the bread containing the byproduct relative to their PI toward the control bread.

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Section: Introductionmentioning

confidence: 99%

Consumer Response to Tomato Pomace Powder as an Ingredient in Bread: Impact of Sensory Liking and Benefit Information on Purchase Intent

Concha-Meyer

Durham

Colonna

et al. 2019

Journal of Food Science

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“…Epidemiological studies have shown that those diets are associated with a lower risk of developing chronic diseases, such as cardiovascular disease and cancer (Hollman, Hertog, & Katan, ). The cardioprotective action of flavonoids has been associated with several effects, including inhibition of LDL oxidation, decreased platelet aggregation, improved endothelial function, and more recently, reduced cholesterol levels (Kes & Bašić‐Jukić, ; Kurowska & Manthey, ; Monsalve, Concha‐Meyer, Palomo, & Fuentes, ). Due to the current population growth speed, it became extremely necessary to take advantage of unconventional foods or neglected parts of conventional foods such as seeds, stalks, and leaves, demanding new studies regarding their functionality.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of beet (Beta vulgaris) leaves extract against oxidative stress in endothelial cells in vitro

Silva

Morelli

Pavan

et al. 2020

Phytotherapy Research

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Beetroot is an herb used worldwide as a food product, raw material for food industry, ethanol production and source of food coloring. Beet leaves are an unconventional food with antioxidant properties, which might neutralize reactive oxygen species (ROS) induced by oxidized Low‐Density Lipoprotein (LDL) present in dyslipidemias. This study aimed to elucidate the effects of beet leaves on the suppression of LDL oxidative processes. Beet leaves extract was produced, characterized, and tested for its antioxidant capacity using endothelial cells in vitro. A model of human umbilical vein endothelial cells was used in various tests, including viability assay, molecular analysis of antioxidant genes, ROS labeling, and macrophage adhesion assay. The extract improved the antioxidative protection of endothelial cells against different agents including oxidized LDL‐cholesterol and H2O2. It acted on ROS directly due to its high content of natural antioxidants, but also due to the activation and improvement of cellular defenses such as Superoxide dismutase 1, Superoxide dismutase 2, and catalase. The inhibition of LDL‐mediated oxidative effects on endothelial cells may turn this unconventional food a functional food with great potential for phytotherapy of atherosclerosis as an adjuvant for medicinal treatments.

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“…Показано также, что комбинированная антигипертензивная терапия антагонистом кальция и ингибитором ангиотензинпревращающего фермента увеличивает расчетный сосудистый возраст пациентов в среднем на девять лет [55,56]. Для защиты эндотелия исследуются растительные средства, богатые полифенолами [57,58].…”

Section: диагностика профилактика и коррекция сосудистых расстройствunclassified

Maladaptive neuropathological syndrome of blood vessel aging

Artemenkov

2019

Russ J Cardiol

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This article discusses the relationship between maladaptation and blood vessel aging. The work shows that upright posture created an additional load on the circulatory system, and the lifestyle of a modern human is an additional risk factor of cardiovascular diseases. It has been suggested that a disorder of the nervous regulation of vascular tone is the main etiopathogenetic mechanism of morphofunctional changes in blood vessels and their aging. We discussed the statute that vascular reactions in humans is based on the formation of a maladaptive circuit in the cerebral cortex, consisting of a matrix of motor, sensory and associative cortical neurons involved in the maladaptive process. This hypothesis is based on the fact that any irritations entering the cerebral cortex from the periphery (thermal, pain, and others) cause cortical-vascular reflex reactions that change their tonic activity. Based on this principle, a model of vascular aging is further constructed, which is based on the maladaptive damage to all layers of the vascular wall (intima, media and adventitia). The opinion is expressed about the need for early diagnosis and prevention of vascular disorders to maintain human health. In conclusion, it is concluded that if the age of a person is really determined by the age of his blood vessels, then in order to achieve active longevity it is necessary to normalize the relationship in the adaptation-maladaptation-environment. Detailed study of hypertrophy and calcification of blood vessels is needed, since aging always reveals vascular wall thickening and stiffness increase.

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Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables

Cited by 29 publications

References 162 publications

Consumer Response to Tomato Pomace Powder as an Ingredient in Bread: Impact of Sensory Liking and Benefit Information on Purchase Intent

Consumer Response to Tomato Pomace Powder as an Ingredient in Bread: Impact of Sensory Liking and Benefit Information on Purchase Intent

Protective effects of beet (Beta vulgaris) leaves extract against oxidative stress in endothelial cells in vitro

Maladaptive neuropathological syndrome of blood vessel aging

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