Simultaneous Determination of Furan and Vinyl Acetate in Vapor Phase of Mainstream Cigarette Smoke by GC-MS

Abstract

A simple and sensitive method for simultaneous determination of furan and vinyl acetate (VA) in vapor phase of mainstream cigarette smoke with cold trap and gas chromatography-mass spectrometry (GC-MS) was developed. A Cambridge filter pad (CFP) was placed in front of the impingers of smoking machine to remove the particle phase from cigarette smoke. Furan and VA in vapor phase of mainstream cigarette smoke were collected in two impingers connected in series by filled with methanol at -78°C. The solutions were added with deuterium-labeled furan-d 4 and VA-d 6 as internal standards and analyzed by GC-MS. The results showed that the calibration curves for furan and VA were linear (r 2 > 0.9995) over the studied concentration range. The intra-and inter-day precision values for furan and VA were <7.07% and <9.62%, respectively. The extraction recoveries of furan and VA were in the range of 94.5-97.7% and 92.3-94.9%, respectively. Moreover, the limits of detection for furan and VA were 0.028 µg mL -1 and 1.3 ng mL -1 , respectively. The validated method has been successfully applied to determine the emissions of furan and VA in the vapor phase of mainstream cigarette smoke under International Organization for Standardization (ISO) and Canadian Intense (CI) smoking regimen.

Harmful and Potentially Harmful Constituents in the Filler and Smoke of Tobacco-Containing Tobacco Products

“…However, vinyl acetate is quantifiable in the smoke of some brands for all cigar types examined (52–90%; category 3c), while 2,3-benzofuran, ethylbenzene, ethylene oxide, furan, nitromethane, propylene oxide, and styrene are quantifiable in the smoke of all cigar brands examined (category 3d). As VSVs are primarily combustion products, the lack of quantifiability of these VSVs in the filler is expected. − It may be beneficial to understand the sources of the differences (e.g., testing method sensitivity, HPHC formation mechanism) of why nitrobenzene and 2-nitropropane are not quantifiable in the smoke of any cigar and cigarette brand examined, while all other examined VSVs were quantifiable in the smoke of most cigar brands. Conflicting results for nitrobenzene and 2-nitropropane in cigarette smoke had been reported. ,,− Test method sensitivity likely contributes to the conflicts.…”

Consumption Habits and Brand Loyalty of Belgian Coffee Consumers

“…Beside coffee, smoking is also considered to be another source of exposure to the molecules addressed in this work [ 19 ]. Furan concentration can reach 30.3 µg × cigarette −1 due to incomplete combustion [ 20 ]. Therefore, additional questions were asked in this survey about smoking habits to evaluate any potential effect of smoking on the consumption habits of coffee.…”