Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

Silva, Vladimir Costa; Barros-Oliveira, Maria da Conceição; Borges, Rafael Soares; Tavares, Cléciton Braga; Borges, Umbelina Soares; Alves-Ribeiro, Francisco Adelton; Silva, Vladimir C.; Silva, Benedito B. da

doi:10.1590/0001-3765201620160169

Cited by 8 publications

(5 citation statements)

References 48 publications

(21 reference statements)

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“…Notably, IGF1 , a gene showing abnormal expression in the Ras pathway in this study, plays an important role in overall growth and anabolism 57 . It is also a key modulator of cell proliferation, differentiation, apoptosis, and immune tolerance of decidual NK cells at the maternal‐fetal interface, and thus contributes to a successful pregnancy 58–61 . In addition to its role in physiological metabolism, IGF1 plays important regulatory roles in immune regulation and inflammation, 62 such as promoting the killing function of human peripheral blood NK(pNK) cells 63 .…”

Section: Discussionmentioning

confidence: 83%

“…57 It is also a key modulator of cell proliferation, differentiation, apoptosis, and immune tolerance of decidual NK cells at the maternal-fetal interface, and thus contributes to a successful pregnancy. [58][59][60][61] In addition to its role in physiological metabolism, IGF1 plays important regulatory roles in immune regulation and inflammation, 62 such as promoting the killing function of human peripheral blood NK(pNK) cells. 63 pNK are innate immune cells that can function without antigens, accounting for 10% to 15% of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

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Integrated analysis of lncRNA and mRNA expression profiles in patients with unexplained recurrent spontaneous abortion

Zhu¹,

Du²,

Gu³

et al. 2023

American J Rep Immunol

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Problem Unexplained recurrent spontaneous abortion (URSA) is one of the most frustrating and confounding conditions in reproductive medicine, and its exact pathogenesis has not been clearly established. Method of study In this study, we used RNA sequencing to characterize the mRNA and lncRNA expression profiles in peripheral blood. Thereafter, enrichment analysis was performed to determine the functions of the differentially expressed genes, and Cytoscape was used to construct lncRNA‐mRNA interaction networks. Results Our results showed that the peripheral blood of patients with URSA has distinct mRNA and lncRNA expression profiles, with a total of 359 mRNAs and 683 lncRNAs being differentially expressed. Moreover, the top hub genes, including IGF1, PPARG, CCL3, RETN, SERPINE1, HESX1, and PRL, were identified and further validated using real‐time quantitative PCR. Furthermore, we demonstrated a lncRNA‐mRNA interaction network that achieved 12 key lncRNAs and their targeted mRNAs are involved in systemic lupus erythematosus, allograft rejection, and complement and coagulation cascades. Finally, the correlation between immune cell subtypes and IGF1 expression was evaluated; a negative correlation was observed with the proportion of natural killer cells, which increased significantly in URSA. Conclusion We identified seven top hub genes, constructed a lncRNA‐related network and suggested that IGF1 plays a key role in regulating maternal immune response by affecting NK and T cells’ function, which helps to identify the pathogenesis of URSA.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Integrated analysis of lncRNA and mRNA expression profiles in patients with unexplained recurrent spontaneous abortion

Zhu¹,

Du²,

Gu³

et al. 2023

American J Rep Immunol

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“…Women with BRCA1 loss-of-function mutations in milk-consuming Western societies may thus exhibit increased susceptibility to milk-derived IGF-1 signaling as mutant BRCA1 exhibits less inhibitory activity on IGF-1 and IGF1R expression [ 123 , 124 ]. Furthermore, women with certain FTO and IGF1 gain-of-function gene polymorphisms appear to be at increased risk for BCa [ 26 – 28 , 188 , 189 ] (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

et al. 2023

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Purpose of Review This review evaluates cow milk’s impact on breast carcinogenesis by linking recent epidemiological evidence and new insights into the molecular signaling of milk and its constituents in breast cancer (BCa) pathogenesis. Recent Findings Recent prospective cohort studies support the association between cow’s milk consumption and the risk of estrogen receptor-α-positive (ER+) BCa. Milk is a complex biological fluid that increases systemic insulin-like growth factor 1 (IGF-1), insulin and estrogen signaling, and interacting hormonal promoters of BCa. Further potential oncogenic components of commercial milk include exosomal microRNAs (miR-148a-3p, miR-21-5p), bovine meat and milk factors, aflatoxin M1, bisphenol A, pesticides, and micro- and nanoplastics. Individuals with BRCA1 loss-of-function mutations and FTO and IGF1 gain-of-function polymorphisms enhancing IGF-1/mTORC1 signaling may be at increased risk for milk-induced ER+ BCa. Summary Recent prospective epidemiological and pathobiochemical studies identify commercial milk consumption as a critical risk factor of ER+ BCa. Large meta-analyses gathering individuals of different ethnic origins with milk derived from dairy cows of varying genetic backgrounds and diverse feeding procedures as well as missing data on thermal processing of milk (pasteurization versus ultra-heat treatment) make multi-national meta-analyses unsuitable for BCa risk estimations in susceptible populations. Future studies are required that consider all vulnerable periods of breast carcinogenesis to cow’s milk exposure, beginning during the perinatal period and puberty, since these are the most critical periods of mammary gland morphogenesis. Notwithstanding the need for better studies including detailed information on milk processing and vulnerable periods of human breast carcinogenesis, the available evidence suggests that dietary guidelines on milk consumption may have to be reconsidered.

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“…Currently, IGF1 was found to be involved in many cancers, such as lung cancer [26], cervical cancer [27], pancreatic cancer [28], and esophageal carcinoma [29]. In breast cancer, IGF-1 gene polymorphism was associated with an increased risk for this cancer [30]. IGF-1 binding to the insulin-like growth factor receptor-type 1 (IGF-1R) can modulate cell metabolism, stimulate proliferation, and promote metastasis in BC [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193

Gao

Han

et al. 2022

Appl Biol Chem

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Background Increasing evidence has suggested that circular RNAs (circRNAs) play critical roles in breast cancer (BC) progression. However, the expression level and potential functional role of circRNA centrosomal protein 85 (circCEP85) in BC remains largely unknown. Here, we aimed to explore the role of circCEP85 in BC. Methods The levels of circCEP85, insuline-like growth factor I (IGF1) mRNA and microRNA-1193 (miR-1193) were examined by quantitative real-time polymerase chain reaction. The protein level was measured by Western blot. Cell proliferation, migration, apoptosis, angiogenesis and stemness were assessed by cell counting kit-8, 5-ethynyl-2’-deoxyuridine assay, transwell assay, flow cytometry, tube formation and sphere formation assays. Xenograft mouse models were conducted to evaluate the effect of circCEP85 in BC in vivo. Moreover, dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation (RIP) assays were preformed to confirm the interaction between miR-1193 and circCEP85 or IGF1. Results CircCEP85 was upregulated in BC tissues and cells. Silencing of circCEP85 inhibited proliferation, invasion, angiogenesis and stemness, but promoted apoptosis in BC cells in vitro. In addition, circCEP85 silencing inhibited tumor growth in vivo. Mechanistically, circCEP85 elevated IGF1 expression via sponging miR-1193 to promote breast cancer progression. Conclusion The circCEP85-miR-1193-IGF1 axis regulated BC progression via the competitive endogenous RNA (ceRNA) mechanism. CircCEP85 might be a prognostic biomarker and therapeutic target for BC.

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Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

Cited by 8 publications

References 48 publications

Integrated analysis of lncRNA and mRNA expression profiles in patients with unexplained recurrent spontaneous abortion

Integrated analysis of lncRNA and mRNA expression profiles in patients with unexplained recurrent spontaneous abortion

The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression

CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193

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