Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Sousa, Cristina Paiva de; Dias, Isabel; López-Peña, Mónica; Camassa, José Arthur de Abreu; Lourenço, P.; Judas, F; Gomes, Manuela E.; Reis, Rui L.

doi:10.1590/0001-3765201520150008

Cited by 59 publications

(44 citation statements)

References 50 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So the third group and the second group are the better fractured bone healing than the first group, depending on the serial rates of alkaline phosphatase enzyme concentrations in serum. This is confirmed by Kanwar et al and Sousa et al (27,28), they said that, the high levels of alkaline phosphatase in the serum indicated to the activity of osteoblast cells, and new bone formation. There was no significant difference in concentrations rates of calcium in the three main groups despite the increasing in concentrations in the weeks followed the operation.…”

Section: Discussionsupporting

confidence: 56%

Effects of platelets rich fibrin and bone marrow on the healing of distal radial fracture in local dogs: Comparative study

Thanoon¹,

Eesa²,

Abed³

2019

IJVS

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of platelets rich fibrin and bone marrow on distal radial fracture healing in local breed dogs. Twenty four adult animals (males and females), mean aged 2.6 ±0.15 years, and the mean body weight 24.58 ±1.07 kg were used. The experimental animals were randomly divided into three equal groups. First group (Control group), transverse fracture was induced in the distal portion of radial bone and immobilized by Plaster of Paris, the fracture line didn't treated with any material. Second group (platelets rich fibrin group), the fracture line was surrounded by the platelets rich fibrin. Third group (bone marrow group), the fracture line was surrounded by autologous bone marrow. The radiographic results confirmed that the fracture healing was faster and superior in third group compared with first and second groups. The hematological results showed an increasing in concentration rates of alkaline phosphatase enzyme and calcium at the weeks that follows surgical operation. Depending on the serial rates of alkaline phosphatase, the third group and the second group are the better fractured bone healing than the first group. In conclusion, the results revealed that, the using of bone marrow and platelets rich fibrin improved and enhanced the healing of distal radial fracture.

show abstract

Section: Discussionsupporting

confidence: 56%

Effects of platelets rich fibrin and bone marrow on the healing of distal radial fracture in local dogs: Comparative study

Thanoon¹,

Eesa²,

Abed³

2019

IJVS

View full text Add to dashboard Cite

show abstract

“…A similar picture is described by authors who reviewed the role and potential of biochemical serum markers as indicators of fracture healing disturbances [33, 34, 36, 50, 51]. In theory, the above molecules could reflect a poor response to the regenerative treatment, but this cannot be ascertained in our study because of the lack of failed cases.…”

Section: Discussionsupporting

confidence: 68%

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Granchi

Gómez‐Barrena

Rojewski

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

In this clinical trial, we investigated if biochemical bone turnover markers (BTM) changed according to the progression of bone healing induced by autologous expanded MSC combined with a biphasic calcium phosphate in patients with delayed union or nonunion of long bone fractures. Bone formation markers, bone resorption markers, and osteoclast regulatory proteins were measured by enzymatic immunoassay before surgery and after 6, 12, and 24 weeks. A satisfactory bone healing was obtained in 23 out of 24 patients. Nine subjects reached a good consolidation already at 12 weeks, and they were considered as the “early consolidation” group. We found that bone-specific alkaline phosphatase (BAP), C-terminal propeptide of type I procollagen (PICP), and beta crosslaps collagen (CTX) changed after the regenerative treatment, BAP and CTX correlated to the imaging results collected at 12 and 24 weeks, and BAP variation along the healing course differed in patients who had an “early consolidation.” A remarkable decrease in BAP and PICP was observed at all time points in a single patient who experienced a treatment failure, but the predictive value of BTM changes cannot be determined. Our findings suggest that BTM are promising tools for monitoring cell therapy efficacy in bone nonunions, but studies with larger patient numbers are required to confirm these preliminary results.

show abstract

“…BTMs could provide important information concerning bone metabolism at a systemic level, namely about bone remodelling process during induction of osteoporosis and its treatment in experimental orthopaedic studies. Recently it was developed a study by Baharuddin et al (2014) in sheep with osteoclast regulatory proteinreceptor activator of nuclear factor NF-κB ligand (RANKL) produced by osteocytes, osteoblasts and immune system cells, its membrane-bound receptor (RANK) in the osteoclast precursor cells and osteoprotegerin (OPG) as new potential bone markers in future (Sousa et al 2015), nevertheless more studies would be necessary to assess the usefulness of BTMs in this scientific field. …”

Section: Discussionmentioning

confidence: 99%

Bone turnover markers in sheep and goat: A review of the scientific literature

Camassa

Diogo

Sousa

et al. 2017

An. Acad. Bras. Ciênc.

Self Cite

View full text Add to dashboard Cite

Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.

show abstract

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Cited by 59 publications

References 50 publications

Effects of platelets rich fibrin and bone marrow on the healing of distal radial fracture in local dogs: Comparative study

Effects of platelets rich fibrin and bone marrow on the healing of distal radial fracture in local dogs: Comparative study

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Bone turnover markers in sheep and goat: A review of the scientific literature

Contact Info

Product

Resources

About