Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Klosterhoff, Marta da Costa; Júnior, Joaber Pereira; Rodrigues, Ricardo Vieira; Gusmão, Emeline Pereira; Sampaio, Luís André; Tesser, Marcelo Borges; Romano, Luís Alberto

doi:10.1590/0001-3765201520140623

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…Histologically differences are observed, being observed in humans a clear differentiation between cortex and medulla, characteristic not observed in the studied fish (Roberts, 2012;Mokhtar, 2017). The presence Hassall's corpuscles are also discussed, with such corpuscles related to aging and the thymic involution, being for several authors nonexistent in fish and for others are present (Zhu et al, 2013;Klosterhoff et al, 2015). In this study Hassall's corpuscles were found very evident in Rachycentron canadum.…”

Section: Discussionsupporting

confidence: 52%

“…In vertebrates, the CD3 complex and CD4 and CD8 co-receptors are essential for the transduction of signals during the T cells activation. The presence of these receptors in the initial phase of ontogenic development has a fundamental role in the immune system efficiency (Klosterhoff et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Its superficial location suggests a certain vulnerability to severe fungal and bacterial infections (Zapata et al, 1996). Regarding the embryonic development of the thymus in fish, it has been studied and established in some species, for example, that the thymus appears between 14 and 16 days after hatching in Rachycentron canadum (Klosterhoff et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Histology of the Human and Teleost Fish Thymus / Histologia Comparativa De Timo De Humanos E Peixes Teleósteos

Klosterhoff

Medeiros

Guerreiro

et al. 2020

BJD

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Thymus is considered a key component of the vertebrates' immune system. It is an organ that is only found in these animals whose development may be accompanied through the evolutionary scale, being considered as a facilitator and regulator in the interaction of lymphoid cells and lymphoid organs. In this study not only a morphological but also functional homology were demonstrated, in that it affects the immune system, of the humans and teleost fish thymus. The material of study was composed of the thymus tissue samples of humans who were donated by the

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Histology of the Human and Teleost Fish Thymus / Histologia Comparativa De Timo De Humanos E Peixes Teleósteos

Klosterhoff

Medeiros

Guerreiro

et al. 2020

BJD

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“…The thymic primordia of carp appeared about 2 dph [ 36 ], and that of sea bream appeared at 11 dph [ 37 ], while, that of Paralichthys olivaceus appeared at 10–15 dph [ 38 ], and the thymic primordia of Atlantic sturgeon appeared at 48 dph [ 39 ]. The thymus of cobia began to appear at 7 dph, and lymphocytes appeared in the thymus at 15 dph, and the formation of immune memory was consistent with the formation of the thymus [ 40 ]. In the present study, the thymic primordium was observed at 2 dph.…”

Section: Discussionmentioning

confidence: 99%

Rag1 and Rag2 Gene Expressions Identify Lymphopoietic Tissues in Larvae of Rice-Field Eel (Monopterus albus)

Liu

Jiang

Liu

et al. 2022

IJMS

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In immature lymphocytes, recombination activating genes 1 and 2 are necessary for antigen receptor V (D) J recombination, representing immature lymphocyte biomarkers. Herein, we cloned and sequenced rice-field eel rag1 and rag2 genes. Their expressions in the thymus, liver, and kidney were significant from 0 days post hatching (dph) to 45 dph, peaking at 45 dph in these three tissues. In situ hybridization detected high rag1 and rag2 expressions in the liver, kidney, and thymus of rice-field eel from 2 to 45 dph, suggesting that multiple tissues of rice-field eel contain lymphocyte lineage cells and undergo lymphopoiesis. Tissue morphology was used to observe lymphopoiesis development in these three tissues. The thymus primordium began to develop at 2 dph, while the kidney and liver have generated. Our findings verified that the thymus is the primary lymphopoietic tissue and suggested that, in rice-field eel, lymphocyte differentiation also occurs in the liver and kidney.

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“…Immune System of Fish: An Evolutionary Perspective DOI: http://dx.doi.org/10.5772/intechopen.99541 of the fish thymus [27]. Thymus in the fishes has frequent record of variation in morphology due to the absence of cortico-medullary junction [28]. So, in many species it is not possible to differentiate between cortex and medulla that is found in higher vertebrates [29].…”

Section: Referencesmentioning

confidence: 99%

Immune System of Fish: An Evolutionary Perspective

Sahoo¹,

Banu²,

Prakash³

et al. 2021

Antimicrobial Immune Response

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Fishes are the most successful and diverse group of vertebrate animals, first appeared during Devonian period. Despite of certain differences, the immune system of fish is physiologically similar to that of higher vertebrates. The heterogenous group of fishes are the apparent link between innate immunity and the first appearance of the adaptive immune response. Importantly, fishes have immune organs homologous to that of mammalian immune system. In comparison to higher vertebrates, fishes live free in their environment from the early embryonic stage and during that time mostly they are dependent on non-specific immune system for their survival. In the fishes, non-specific immunity is the fundamental defense mechanism, therewith acquired immunity also plays key role in maintaining homeostasis by activation though a system of receptors proteins, which identify pathogen associated molecular pattern typical of pathogenic microorganism includes lipopolysaccharides, peptidoglycans, DNA, RNA and other molecules that are typically not present on the surface of multicellular organism. There are several external factors like environmental factors, biological factors, stress and internal factors like genetic makeup, age and sex, maternal effect etc. can affect immunological defense capabilities of the fishes.

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Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentroncanadum )

Cited by 11 publications

References 30 publications

Comparative Histology of the Human and Teleost Fish Thymus / Histologia Comparativa De Timo De Humanos E Peixes Teleósteos

Comparative Histology of the Human and Teleost Fish Thymus / Histologia Comparativa De Timo De Humanos E Peixes Teleósteos

Rag1 and Rag2 Gene Expressions Identify Lymphopoietic Tissues in Larvae of Rice-Field Eel (Monopterus albus)

Immune System of Fish: An Evolutionary Perspective

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