Effects of cigarette smoke condensate on the production and characterization of exopolysaccharides by Bifidobacterium

Hu, Jinqiang; Wei, Tao; Sun, Siwen; Zhao, Aijing; Xu, Chunping

doi:10.1590/0001-3765201520140518

Cited by 14 publications

(12 citation statements)

References 22 publications

(18 reference statements)

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“…Although a causal relationship between SCFAs and protection in this study was not confirmed, both cigarette smoke 95 and environmental particulate matter 96 reduced SCFA concentrations in rodents, and cigarette smoke condensate reduced their production in vitro 90 .…”

Section: [H3] Microbiota and Copdcontrasting

confidence: 74%

“…The causes of smoking-associated changes in microbiome composition are likely a combination of environmental, host and microbial changes such as intestinal and immune disruption, impaired clearance of pathogens 84,85 , acidification of gastric contents 86 and ingestion of bacteria that occur in cigarettes 87 . Furthermore, cigarette smoke can directly affect the virulence of both bacteria 88 and fungi 89 , as well as altering the growth and exopolysaccharide structure of known gut bacteria such as Bifidobacterium animalis 90 , which may contribute to dysbiosis. Even following smoking cessation, many of these changes that cause dysbiosis persist for prolonged periods, and thus any therapeutic intervention to restore the microbiota may potentially require repeated administration to avoid relapse.…”

Section: [H3] Microbiota and Copdmentioning

confidence: 99%

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Emerging pathogenic links between microbiota and the gut–lung axis

et al. 2016

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The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut-lung axis. Although the gut-lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.

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Section: [H3] Microbiota and Copdcontrasting

confidence: 74%

Section: [H3] Microbiota and Copdmentioning

confidence: 99%

Emerging pathogenic links between microbiota and the gut–lung axis

et al. 2016

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“…The fact as mentioned above that cigarette smoke or side-stream smoking decreases the amount of Bifidobacterium [124], mainly butyrate-producing bacteria with anti-inflammatory and anti-tumor molecule role [172] was highly consistent with the results that butyrate-producing bacteria are depleted in cancer patients [170]. In addition, in vitro and in vivo studies found that cigarette smoke not only decrease the fecal abundance of Bifidobacterium but also reduce its production of short chain fatty acids (SCFAs) [124, 173], immune-regulatory molecules modulating immune and inflammatory response within many diseases, and reductions in the concentration of SCFAs especially butyrate in colorectal tissues were demonstrated to be associated with the possibility of early stage CRC development [174]. Moreover, the smoking-related microbial changes may lead to altered epithelial mucin composition of the mucus layer and increased inflammatory response [175], which play pivotal role in the onset of CRC.…”

Section: Introductionsupporting

confidence: 54%

Smoking and microbiome in oral, airway, gut and some systemic diseases

2019

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The human microbiome harbors a diverse array of microbes which establishes a mutually beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is influenced by both host and environmental factors. Smoking contributes to modifications of the oral, lung and gut microbiome, leading to various diseases, such as periodontitis, asthma, chronic obstructive pulmonary disease, Crohn’s disease, ulcerative colitis and cancers. However, the exact causal relationship between smoking and microbiome alteration remains to be further explored.

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“…132 In addition, some in vitro and animal studies found that cigarette smoke might decrease the fecal abundance of Bifidobacterium and reduce its production of SCFAs. 133, 134 …”

Section: Smokingmentioning

confidence: 99%

Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention

Song

Chan

2019

Clinical Gastroenterology and Hepatology

222

157

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The substantial burden of colorectal cancer and increasing trend in young adults highlight the importance of lifestyle modification as a complement to screening for colorectal cancer prevention. Several dietary and lifestyle factors have been implicated in the development of colorectal cancer, possibly through the intricate metabolic and inflammatory mechanisms. Likewise, as a key metabolic and immune regulator, the gut microbiota has been recognized to play an important role in colorectal tumorigenesis. Increasing data support that environmental factors are crucial determinants for the gut microbial composition and function, whose alterations induce changes in the host gene expression, metabolic regulation, and local and systemic immune response, thereby influencing cancer development. Here, we review the epidemiologic and mechanistic evidence regarding the links between diet and lifestyle and the gut microbiota in the development of colorectal cancer. We focus on factors for which substantial data support their importance for colorectal cancer and their potential role in the gut microbiota, including overweight and obesity, physical activity, dietary patterns, fiber, red and processed meat, marine omega-3 fatty acid, alcohol, and smoking. We also briefly describe other colorectal cancer-preventive factors for which the links with the gut microbiota have been suggested but remain to be mechanistically characterized, including vitamin D status, dairy consumption, and metformin use. Given limitations in available evidence, we highlight the need for further investigations in the relationship between environmental factors, gut microbiota, and colorectal cancer, which may lead to development and clinical translation of potential microbiota-based strategies for cancer prevention.

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Effects of cigarette smoke condensate on the production and characterization of exopolysaccharides by Bifidobacterium

Cited by 14 publications

References 22 publications

Emerging pathogenic links between microbiota and the gut–lung axis

Emerging pathogenic links between microbiota and the gut–lung axis

Smoking and microbiome in oral, airway, gut and some systemic diseases

Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention

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