Prevalence of Candida tropicalis and Candida krusei in onychomycosis in João Pessoa, Paraiba, Brazil from 1999 to 2010

Mendes, Juliana Moura; Rodrigues, Luis A.S.; Pereira, Fillipe de Oliveira; Lima, Edeltrudes O.

doi:10.1590/0001-3765201520130418

Cited by 20 publications

(10 citation statements)

References 8 publications

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“…Although Candida albicans is the main source of infections, other Candida species such as Candida tropicalis have been gradually recognized as common yeast pathogens in recent years (Tan et al, 2015;Wu P. F. et al, 2017). In Asia Pacific and Latin America, C. tropicalis is ranked as the first or second most prevalent non-albicans pathogen (Kumar et al, 2014;Pahwa et al, 2014;Arrua et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Multilocus Sequence Typing Reveals Clonality of Fluconazole-Nonsusceptible Candida tropicalis: A Study From Wuhan to the Global

Wang

Tang

et al. 2020

Front. Microbiol.

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Candida tropicalis is a globally distributed human pathogenic yeast, and its increasing resistance to azoles makes clinical treatment difficult. In this study, we investigated the clinical features, azole resistance and genetic relatedness of 87 C. tropicalis isolates from central China and combined with the global database to explore the relationship between genetic information and fluconazole susceptibility. Of the 55 diploid sequence types (DSTs) identified by multilocus sequence typing (MLST), 27 DSTs were new to the C. tropicalis MLST database. Fluconazole-nonsusceptible (FNS) isolates were genetically closely related. goeBURST analysis showed that DST225, DST376, DST506, and DST546 formed a distinct and unique FNS clonal complex (CC) in Wuhan. The local FNS CC belongs to the large FNS CC (CC2) in China, in which the putative founder DST225 has been reported from the environment. The three most prevalent types (DST506, DST525, and DST546) in Wuhan had high minimum inhibitory concentrations (MICs) for antifungal azoles, and the six possible nosocomial transmissions we captured were all FNS strains, most of which were from CC2. Unique FNS CCs have been found in Singapore (CC8) and India (CC17) and are close to China’s CC2 in the minimum spanning tree. There were no FNS CCs outside Asia. This study is the first to reveal a significant correlation between genetic information and fluconazole susceptibility worldwide and to trace geographical locations, which is of great value for molecular epidemiological surveillance and azole-resistance study of C. tropicalis globally.

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Section: Introductionmentioning

confidence: 99%

Multilocus Sequence Typing Reveals Clonality of Fluconazole-Nonsusceptible Candida tropicalis: A Study From Wuhan to the Global

Wang

Tang

et al. 2020

Front. Microbiol.

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“…Among the Candida spp, C . tropicalis is considered to be the first or second most common pathogenic yeast in some geographical regions such as East Asia and Latin America (Arrua et al, 2015; Kumar et al, 2014; Pahwa et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections

Wang

Tang

et al. 2020

MicrobiologyOpen

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Candida spp. are important components of the microflora of human skin, oral and vaginal mucosa, and gastrointestinal tract. They are important opportunistic pathogens that can cause superficial and invasive infections in human hosts (Falagas et al., 2010). Over the past decade, infections caused by Candida have risen significantly and become an important cause of nosocomial infections, leading to serious public health problems (Gajdács

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“…With an increasing number of immunocompromised patients due to cancer treatment, HIV infection, and/or organ transplantation, C. tropicalis has emerged as a major opportunistic pathogen that can cause serious invasive infections such as endocarditis and the bloodstream and urinary tract infections, resulting in significant morbidity and mortality (Falagas et al, 2010; Fesharaki et al, 2013; Dong et al, 2015; Zuza-Alves et al, 2017; Diba et al, 2018). In certain geographic regions, C. tropicalis is ranked as the first or second most prevalent invasive pathogenic yeast species (Adhikary and Joshi, 2011; Dóczi et al, 2012; Wang et al, 2013; Morii et al, 2014; Pahwa et al, 2014; Arrua et al, 2015; Al-Obaid et al, 2017). However, despite its global medical significance, relatively little is known about its global patterns of genetic variation.…”

Section: Introductionmentioning

confidence: 99%

Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Candida tropicalis

Zhou

Zhang

et al. 2019

Front. Microbiol.

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Candida tropicalis is a globally distributed human pathogenic yeast, especially prevalent in tropical and sub-tropical regions. Over the last several decades, a large number of studies have been published on the genetic diversity and molecular epidemiology of C. tropicalis from different parts of the world. However, the global pattern of genetic variation remains largely unknown. Here we analyzed the published multilocus sequence data at six loci for 876 isolates from 16 countries representing five continents. Our results showed that 280 of the 2677 (10.5%) analyzed nucleotides were polymorphic, resulting in a mean of 82 (a range of 38–150) genotypes per locus and a total of 633 combined diploid sequence types (DSTs). Among these, 93 combined DSTs were shared by 336 strains, including 10 by strains from different continents. Analysis of Molecular Variance (AMOVA) showed that 89% of the observed genetic variations were found within regional and national populations while < 10% was due to among-country separations. Pairwise geographic population analyses showed overall low but statistically significant genetic differentiation between most geographic populations, with the Singaporean and Indian populations being the most distinct from other populations. However, the Mantel test showed no significant correlation between genetic distance and geographic distance among the geographic populations. Consistent with high genetic variation within and limited variations among geographic populations, results from STRUCTURE analyses showed that the 876 isolates could be grouped into 15 genetic clusters, with each cluster having a broad geographic distribution. Together, our results suggest frequent gene flows among certain regional, national, and continental populations of C. tropicalis , resulting in abundant regional and national genetic diversities of this important human fungal pathogen.

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Prevalence of Candida tropicalis and Candida krusei in onychomycosis in João Pessoa, Paraiba, Brazil from 1999 to 2010

Cited by 20 publications

References 8 publications

Multilocus Sequence Typing Reveals Clonality of Fluconazole-Nonsusceptible Candida tropicalis: A Study From Wuhan to the Global

Multilocus Sequence Typing Reveals Clonality of Fluconazole-Nonsusceptible Candida tropicalis: A Study From Wuhan to the Global

Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections

Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Candida tropicalis

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