Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Pejić, Snežana; Todorović, Ana; Stojiljković, Vesna; Gavrilović, Ljubica; Popović, Nataša; Pajović, Snežana B.

doi:10.1590/0001-3765201520130416

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…This may be due to the similarity in the racial population of the study participants. Vitamin C is well known for its antioxidant properties and some recent epidemiological studies suggest a reduction in levels of antioxidants in uterine fibroids [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Makwe¹,

Soibi‐Harry²,

Rimi³

et al. 2021

Cureus

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Background: Uterine fibroids significantly affect the quality of life of reproductive-age women. The socioeconomic cost and psychological strain on patients cannot be overemphasized. The role of diet and micronutrients on the onset and development of uterine fibroids has come under review in recent times. This study assessed the levels of some micronutrients and trace elements in the serum of women with uterine fibroids.Methods: Eighty-eight women were recruited from the Gynecology Outpatient Clinic of Lagos University Teaching Hospital, 44 with uterine fibroids and 44 women without uterine fibroids. Blood samples were obtained and analyzed for serum levels of selected micronutrients (vitamins A, C, D, and E) and trace elements (calcium, magnesium, and phosphorus). Pelvic ultrasonography was performed on all study participants.Results: Women with uterine fibroids had statistically significant lower serum levels of vitamin C (1.20 ± 0.59 vs 1.62 ± 1.75 mg/dl; p = 0.01), vitamin D (34.23 ±10.67 vs 37.06 ±11.46 ng/ml; p = 0.04), and calcium (2.27 ± 0.19 vs 2.32 ± 0.09 mmol/L; p = 0.02) compared with women without uterine fibroids. There was no significant difference in the serum levels of vitamins A (39.63 ± 15.71 vs 40.09 ±15.26 μ/dl; p = 0.91), vitamin E (5.44 ± 4.65 vs 5.26 ± 4.62 µg/mL; p = 0.87), magnesium (0.89 ± 0.09 vs 0.89 ± 0.08 mmol/L; p = 0.78), and phosphorus (1.29 ± 0.38 vs 1.19 ± 0.17 mmol/L; p = 0.14) in women with uterine fibroids compared to those without uterine fibroids.Conclusion: This study showed lower serum levels of vitamin C, vitamin D, and calcium in women with uterine fibroids when compared to women without uterine fibroids. It is possible that these micronutrients and trace elements may play a role in the etiopathogenesis, progression, and/or proliferation of uterine fibroids. However, whether the findings of low serum levels of these elements are a cause or an effect of uterine fibroid, is yet to be determined.

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Section: Discussionmentioning

confidence: 99%

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Makwe¹,

Soibi‐Harry²,

Rimi³

et al. 2021

Cureus

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“…11 There is increasing interest and research on the role of oxidative stress in the pathogenesis of uterine fibroids. [14][15][16][17] In a study by Santuli et al, they found significantly higher levels of AOPP and PC in the serum of women with uterine fibroids. 18 It has been suggested that certain antioxidant supplements may be useful in the management of some gynaecologic diseases.…”

Section: Introductionmentioning

confidence: 95%

Serum Oxidative Stress Markers in Women with Uterine Fibroids in Lagos, Nigeria

Makwe

Oluwole

et al. 2021

Preprint

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BackgroundUterine fibroid is the most common benign gynaecological tumour in women of reproductive age group, with significant impact on the quality of life, economy, morbidity and sometimes mortality of affected women. Black women of reproductive age group are more likely to develop uterine fibroids. Although available evidence suggests racial and genetic predisposition to the aetiology of uterine fibroid, oxidative stress has been implicated in the onset and progression of uterine fibroids. Epidemiological and experimental studies have suggested that oxidative stress may play an important role in the pathogenesis of gynaecological diseases including uterine fibroids.Aim and ObjectivesThis study aims to assess the serum levels of antioxidants (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) and oxidants (protein carbonyl (PC), advanced oxidation protein products (AOPP)) in women with uterine fibroids and to identify any association between the size of uterine fibroids and serum levels of the analysed antioxidants and oxidants.MethodsForty-four women with ultrasound diagnosis of uterine fibroids and 44 women without uterine fibroids were recruited from a University Teaching Hospital. Blood samples were obtained and analysed for serum levels of selected antioxidants (CAT, SOD, GPx) and oxidants (PC, AOPP). Pelvic ultrasonography was performed on all study participants.ResultsThe median serum levels of antioxidants: CAT (2.20 vs 4.32 ng/ml; p < 0.001); SOD (285.54 vs 380.96 ng/ml; p < 0.001) and GPx (9.67 vs 11.26 µU/ml; p < 0.001) were significantly lower in women with uterine fibroids. The median serum levels of oxidants: PC (162.08 vs 142.36 ng/ml; p = 0.04); and AOPP (22.42 vs 13.94 ng/ml; p < 0.001) were significantly higher in women with uterine fibroids. There was a strong negative correlation between serum levels of AOPP and SOD (r = -0.95; p < 0.001) in women with uterine fibroids. The maximum diameter of fibroids showed a significant positive correlation with AOPP (r = 1.000; p < 0.001) and a negative correlation with SOD (r = -1.000; p < 0.001).ConclusionWomen with uterine fibroids had lower levels of antioxidants and higher levels of oxidants. In women with uterine fibroids, AOPP negatively correlated with SOD. There was a positive correlation between fibroid size and AOPP and a negative correlation between fibroid size and SOD. The findings of this study suggests that AOPP and SOD may play an important role in uterine fibroids.

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“…We have previously shown that gonadotropins influence the antioxidant enzyme (AOE) activity in women with uterine hyperplasia simplex, hyperplasia complex, leiomyoma, and polyps [12,13,14,15]. Also, the extent of AOE and lipid hydroperoxides (LOOH) alterations varied with the examined gynecological diagnosis, including adenocarcinoma [16].…”

Section: Introductionmentioning

confidence: 99%

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

et al. 2019

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We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.

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Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Cited by 11 publications

References 38 publications

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Serum Oxidative Stress Markers in Women with Uterine Fibroids in Lagos, Nigeria

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma

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