Lymphocyte subset reference intervals in blood donors from northeastern Brazil

Torres, Alex José Leite; Cisneiros, Patrícia; Guedes, Rosa; Grassi, Maria Fernanda Rios; Meyer, Roberto; Bendicho, Maria Teresita; Lopes, Tiago da Silva; Félix, Gabriela; Netto, Eduardo Martins; Brites, Carlos; Abe‐Sandes, Kiyoko; Brandão, Claudio; Alcântara-Neves, Neuza Maria; Freire, Songelí Menezes

doi:10.1590/0001-3765201520130114

Cited by 4 publications

(3 citation statements)

References 23 publications

(11 reference statements)

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“…Despite these results a question still remains: which are the normal (optimum) levels of NK? An additional layer of complexity come from the fact that NK % varies dependently on gender, ethnical, and racial backgrounds [2, 6,11,27,33]. NK % and NKc levels is increased in males compared to females.…”

Section: Resultsmentioning

confidence: 99%

Numbers of natural killers lymphocytes do not determine their cytotoxicity

Dons’koi¹

2019

Biol. Stud.

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Section: Resultsmentioning

confidence: 99%

Numbers of natural killers lymphocytes do not determine their cytotoxicity

Dons’koi¹

2019

Biol. Stud.

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“…Despite these facts, the question still remains: what are the normal (optimum) levels of NK? NK% varies depending on gender, ethnical, and racial backgrounds [36][37][38][39]. Moreover, NK% and NKc levels are higher in males compared to females.…”

Section: Discussionmentioning

confidence: 99%

Natural killer frequency determines natural killer cytotoxicity directly in accentuated zones and indirectly in “moderate-to-normal frequency” segment

Dons’koi¹,

Chernyshov²,

Osypchuk³

et al. 2020

cejoi

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“…To the best of our knowledge, the first study aiming to standardize CD45RA + T cells dates to 1992 in Spain ( 221 ). Other studies aiming to standardize the phenotyping of CD45RA + naïve and CD45RO + memory T cells have since been conducted in Kuwaiti Arabian ( 93 ), American ( 222 ), German ( 223 ), Italian ( 224 ), Dutch ( 225 , 226 ), Brazilian ( 227 ) and Moroccan ( 228 ) healthy donors of different ages.…”

Section: Combined Immunodeficiencies or Immunodeficiencies Affecting Cellular And Humoral Immunitymentioning

confidence: 99%

A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity

et al. 2021

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Inborn errors of immunity (IEI), which were previously termed primary immunodeficiency diseases, represent a large and growing heterogeneous group of diseases that are mostly monogenic. In addition to increased susceptibility to infections, other clinical phenotypes have recently been associated with IEI, such as autoimmune disorders, severe allergies, autoinflammatory disorders, benign lymphoproliferative diseases, and malignant manifestations. The IUIS 2019 classification comprises 430 distinct defects that, although rare individually, represent a group affecting a significant number of patients, with an overall prevalence of 1:1,200-2,000 in the general population. Early IEI diagnosis is critical for appropriate therapy and genetic counseling, however, this process is deeply dependent on accurate laboratory tests. Despite the striking importance of laboratory data for clinical immunologists, several IEI-relevant immunoassays still lack standardization, including standardized protocols, reference materials, and external quality assessment programs. Moreover, well-established reference values mostly remain to be determined, especially for early ages, when the most severe conditions manifest and diagnosis is critical for patient survival. In this article, we intend to approach the issue of standardization and quality control of the nonfunctional diagnostic tests used for IEI, focusing on those frequently utilized in clinical practice. Herein, we will focus on discussing the issues of nonfunctional immunoassays (flow cytometry, enzyme-linked immunosorbent assays, and turbidimetry/nephelometry, among others), as defined by the pure quantification of proteins or cell subsets without cell activation or cell culture-based methods.

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Lymphocyte subset reference intervals in blood donors from northeastern Brazil

Cited by 4 publications

References 23 publications

Numbers of natural killers lymphocytes do not determine their cytotoxicity

Numbers of natural killers lymphocytes do not determine their cytotoxicity

Natural killer frequency determines natural killer cytotoxicity directly in accentuated zones and indirectly in “moderate-to-normal frequency” segment

A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity

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