Immunologic Abnormalities in Chronic Fatigue Syndrome

Tirelli, Umberto; Bernardi, Daniele; Improta, Salvatore; Pinto, Antonio

doi:10.1300/j092v02n01_07

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…Evidence of chronic immune dysfunction in CFS has been reported by several groups (Klimas et al, 1990; Straus et al, 1993; Hilgers et al, 1994; Keller et al, 1994; Tirelli et al, 1996; Gupta et al, 1997; Patarca et al, 1997; Patarca-Montero et al, 2001; Seigel et al 2006) though the exact nature of this dysfunction remains unclear (Maher et al, 2003). A principal avenue of investigation has been the measurement in blood of immune signals conducted by cytokines.…”

Section: Introductionmentioning

confidence: 95%

A formal analysis of cytokine networks in Chronic Fatigue Syndrome

Broderick

Fuite

Kreitz

et al. 2010

Brain, Behavior, and Immunity

182

184

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Chronic Fatigue Syndrome (CFS) is a complex illness affecting 4 million Americans for which no characteristic lesion has been identified. Instead of searching for a deficiency in any single marker, we propose that CFS is associated with a profound imbalance in the regulation of immune function forcing a departure from standard preprogrammed responses. To identify these imbalances we apply network analysis to the co-expression of 16 cytokines in CFS subjects and healthy controls. Concentrations of 1b,2,4,5,6,8,10,12,13,15, 17 and 23, and TNF-α were measured in the plasma of 40 female CFS and 59 case-matched controls. Cytokine co-expression networks were constructed from the pair-wise mutual information (MI) patterns found within each subject group. These networks differed in topology significantly more than expected by chance with the CFS network being more hub-like in design. Analysis of local modularity isolated statistically distinct cytokine communities recognizable as pre-programmed immune functional components. These showed highly attenuated Th1 and Th17 immune responses in CFS. High Th2 marker expression but weak interaction patterns pointed to an established Th2 inflammatory milieu. Similarly, altered associations in CFS provided indirect evidence of diminished NK cell responsiveness to IL-12 and LTα stimulus. These observations are consistent with several processes active in latent viral infection and would not have been uncovered by assessing marker expression alone. Furthermore this analysis identifies key subnetworks such as IL-2:IFNγ:TNFα that might be targeted in restoring normal immune function. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptBrain Behav Immun. Author manuscript; available in PMC 2011 October 1. BackgroundChronic Fatigue Syndrome (CFS) is characterized by persistent and unexplained fatigue resulting in severe impairment in daily function and is defined by symptoms, disability, and exclusion of medical and psychiatric conditions that could explain the fatigue (Fukuda et al., 1994;Reeves et al., 2003;Prins et al., 2006). The US Centers for Disease Control and Prevention (CDC) estimates that as many as 4 million people are affected with CFS in the US alone (Reeves et al. 2007;Chandler et al., 2008). Costs to the US economy are estimated at $9.1 billion in lost productivity (Reynolds et al., 2004) and up to $24 billion dollars in health care expenditures annually (Jason et al., 2008). Furthermore complications and co-morbidity can be severe. For example, CFS is associated with chronic and episodic car...

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Section: Introductionmentioning

confidence: 95%

A formal analysis of cytokine networks in Chronic Fatigue Syndrome

Broderick

Fuite

Kreitz

et al. 2010

Brain, Behavior, and Immunity

182

184

View full text Add to dashboard Cite

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“…Chronic fatigue syndrome (CFS) is estimated to cost the American economy over $9 billion each year in lost productivity [ 1 ]. Among other components chronic immune cell dysfunction and activation has been demonstrated in CFS by several groups [ 2 - 4 ]. Though similar in terms of broad lymphocyte classes CFS and non-fatigued subjects can be readily distinguished when specific immune cell subsets are examined.…”

Section: Introductionmentioning

confidence: 99%

Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood

et al. 2008

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Fatigue und Chronic-Fatigue-Syndrom in der Schwangerschaft

Richter

Rath

2005

Gynäkologe

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On li ne pub li ziert: 2. Juli 2005 © Sprin ger Me di zin Ver lag 2005Mü dig keit und Ab ge schla gen heit sind ins be son de re in der Schwan gerschaft häu fig ge äu ßer te Be schwerden und wer den in der Li te ra tur mit dem Be griff "Fa tigue" be legt. In der chro ni schen Form liegt das sog. Chronic-Fa tigue-Syn drom (CFS) vor, wo bei eine Ab gren zung bei der En ti tä ten aufgrund großer Ge mein sam kei ten in der Sym ptom prä sen ta ti on meis tens schwie rig ist. Wie die fol gen de Über-sicht zei gen wird, kön nen so wohl Fatigue als auch das CFS ein erns tes Prob lem wäh rend der ge sam ten Schwanger schaft dar stel len.Fa tigue in der Schwan ger schaft be schreibt einen Sym pto men kom plex häu fig ge äu-ßer ter und sehr un ter schied li cher Er schöp-fungs zu stän de der schwan ge ren Frau. Ursäch lich wer den eine Viel zahl von phy sischen, psy chi schen und in di vi du el len, situa ti ons be ding ten Fak to ren dis ku tiert, die eine Frau wäh rend, aber auch vor und nach der Schwan ger schaft und Still zeit für Fa tigue prä dis po nie ren. Da bei ha ben mehre re Un ter su chun gen eine As so zia ti on zwischen Stress und Fa tigue in Ab hän gig keit von Be las tun gen am Ar beit platz so wie in der häus li chen Um ge bung und ei ner steigen den Mor bi di tät in Schwan ger schaft und Still zeit zei gen kön nen [11,18, 41, 55]. In der chro ni schen Form ist das Chro nicFa tigue-Syn dro me nach heu ti ger Auf fassung auch eng mit an de ren Er kran kungen wie bei spiels wei se der Fi bro my al gie (FM)oder der Neur asthe nie, für die ganz ähn li che So ma ti sie rungs pro zes se cha rakte ris tisch sind, ver knüpft. Trotz ei ner Vielzahl be schrie be ner Di ag no se kri te ri en besteht bei der zeit noch feh len dem wis senschaft li chem Kon sens über die Ätio lo gie und Pa tho ge ne se von Fa tigue und CFS keine zu ver läs si ge Mög lich keit ei ner de fi ni tiven di ag nos ti schen Ob jek ti vie rung, vielmehr prägt die Aus schluss dia gno s tik das ak tu el le di ag nos ti sche Pro ze de re.Bei der Häu fig keit ge äu ßer ter Mü digkeits-und Er schöp fungs zu stän de wäh-rend ei nes sonst un auf fäl li gen Schwan gerschafts ver laufs ver wun dert es da her nicht, dass die Gren zen zwi schen Fa tigue, also den sog. "nor ma len", schwan ger schaft sasso zi ier ten Be schwer den und dem CFS nur all zu oft schwer oder gar nicht aus zuma chen sind. In wie fern an ge sichts die ser flie ßen den Über gän ge bei de En ti tä ten ein ernst zu neh men des kli ni sches Pro b lem für die wer den de Mut ter und ihre Um gebung sein kön nen, soll der fol gen de Über-sichts ar ti kel un ter be son de rer Be rück sichti gung von Schwan ger schaft und Still zeit zei gen. Epi de mio lo gi sche Be trach tun genMit dem Über grei fen des In di vi dua li sierungs pro zes ses auf den weib li chen Le benslauf Mit te der 60er Jah re ha ben die tra ditio nel len Ge schlechts rol len an Gel tung und Über zeu gungs kraft ver lo ren. Noch bis in die 60er Jah re hi nein war die Lebens pla nung jun ger Frau en stark fa mi li en ori en ...

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Immunologic Abnormalities in Chronic Fatigue Syndrome

Cited by 8 publications

References 24 publications

A formal analysis of cytokine networks in Chronic Fatigue Syndrome

A formal analysis of cytokine networks in Chronic Fatigue Syndrome

Evidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood

Fatigue und Chronic-Fatigue-Syndrom in der Schwangerschaft

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