Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Ngwuluka, Ndidi C.

doi:10.1208/s12249-010-9535-4

Cited by 18 publications

(10 citation statements)

References 54 publications

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“…A similar concentration trend to that detected for PZA and POA over the course of therapy was observed for citric acid ethyl ester, dodecyl acrylate, and hippuric acid (Table 1) various medicine capsules (Pole et al, 2016), and likewise, dodecyl acrylate is copolymerized with acrylic acid as a drug coating allowing for drug release in specific pH environments (Ngwuluka, 2010). Similarly, the observed concentration trend for hippuric acid, a normal component of urine that typically elevates in concentration with increased consumption of phenolic compounds (Gatley and Sherratt, 1977), could be related to the use of sodium benzoate as a lubricant during pharmaceutical manufacturing of these tablets and capsules (Varma, 2016).…”

Section: Discussionsupporting

confidence: 72%

Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study

Combrink

Preez

Ronacher

et al. 2019

OMICS: A Journal of Integrative Biology

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Pharmacometabolomics is a rapidly emerging omics science signaling the convergence of clinical pharmacology, metabolomics, precision medicine, and biomarker research. Tuberculosis (TB) treatment outcomes have complex biological, environmental, and social determinants and thus, represent a promising application of pharmacometabolomics. In samples of 23 patients undergoing intensive phase TB therapy for 4 weeks, we identified drug-induced host-metabolome variations before and at repeated time intervals post-treatment: (1) an overall reduction in the oxidative stress levels over the course of TB treatment; (2) a time-dependent induction and inhibition of several enzymes in response to the drugs (CYP2E1, CYP3A4, alcohol dehydrogenase, and aminocarboxymuconate-semialdehyde decarboxylase), and altered oxidative stress levels (aconitase, formylglycinegenerating enzyme, a-ketoglutarate dehydrogenase, and succinate-semialdehyde dehydrogenase); (3) an upregulated urea cycle; and (4) altered insulin production. This is the first study of its kind to indicate changes to the host metabolome in response to intensive TB treatment, at different time intervals during the course of treatment. These results provide new insights into the mechanisms of TB drug metabolism, drug action, and drugrelated side effects, thereby paving the way for the development of improved therapeutic approaches for the disease, and perhaps more importantly, also for monitoring treatment progression.

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Section: Discussionsupporting

confidence: 72%

Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study

Combrink

Preez

Ronacher

et al. 2019

OMICS: A Journal of Integrative Biology

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“…Prominent peaks related to methylene (CH2) asymmetric and symmetric stretching vibrations absorbance band related to PA6 were also observed at 2935 cm -1 and 2861 cm -1 confirming formation of PA6 (27) (28). In addition, these results also confirmed the presence of the amide II band of primary amides, which occurred due to stretching vibration of the C=O double bond and further ascribed to the functionality of the amide I band.…”

Section: Chemical Composition Of Pa6 Nanocompositesupporting

confidence: 56%

“…cm -1 , to 1531 cm -1 for increasing proportion of OA coating (28). The degree of crystallinity is determined from the position and intensity of these crystalline bands, as well as the broader bands from the amorphous phase (30).…”

Section: Chemical Composition Of Pa6 Nanocompositementioning

confidence: 99%

Novel method of healing the fibre reinforced thermoplastic composite: A potential model for offshore applications

Gupta

Huo

White

et al. 2019

Composites Communications

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Continuous fibre reinforced thermoplastic composites are increasingly finding their use as engineering materials in many industries due to the excellent fire, smoke and toxicity performance. However, the composite component produced using automated continuous fibre reinforced thermoplastic tapes laying machine are susceptible to sudden failure emanating from microscale cracks. This study demonstrates the healing potential of a layered Glass Fibre Reinforced Polymer (GFRP) composite consisting of alternative layers of GFRP and a magnetic polyamide-6 (PA-6) nanocomposite (PNC) film. The self-healing process is presented in three steps, viz. (i) polymer nanocomposite synthesis, (ii) preparation of the layered GFRP layered composite sample and (iii) selfhealing and testing of GFRP layered composite sample. Firstly, the multilayer dog bone sample consisting of a magnetic polymer nanocomposite (PNC) film sandwiched between thermoplastic unidirectional GFRP tapes are prepared. Healing is triggered by exposing the damaged multilayer sample to microwave causing selective heating of nanocomposite film and its subsequent melting. The healing process completes when liquid polymer fills the micro-crack in the multilayer tape through capillary action and solidifies upon cooling. The healing yields 84% of the undamaged tensile strength recovery. Results demonstrate the potential application of an autonomous self-healing method for thermoplastic composite used in the offshore environment.

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“…3, a peak attributed to hydrogen bonds and N-H stretching was observed at 3293 cm À1 . Further, the CH 2 asymmetric and symmetric stretch of PA6 can be assigned to the peaks observed at 2934 cm À1 and 2861 cm À1 , 29,30 respectively. Also, the shift in the spectra observed for the OAcoated samples, i.e.…”

Section: Fourier-transform Infrared Spectroscopymentioning

confidence: 95%

Effect of Oleic Acid Coating of Iron Oxide Nanoparticles on Properties of Magnetic Polyamide-6 Nanocomposite

Gupta

Pancholi

et al. 2019

JOM

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This work reports the development and testing of a magnetic polymer (Polyamide 6, PA6) nanocomposite capable of melting when exposed to an external magnetic field. Addition of high concentrations of iron oxide nanoparticles (NPs) can induce quick melting but is detrimental to the mechanical properties of the polymer. To reduce the amount of NPs required for achieving efficient melting, they should be well dispersed in the polymer. In this study, the oleic acid loading on the surfaces of the NPs was varied to study the effect of variations in coatings on the dispersion in the polymer and on the polymer melting time. The NPs functionalized with oleic acid were added to melted monomer e-caprolactam and polymerized using ring-opening polymerization. The resulting PA6 nanocomposite was characterized by Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction and transmission electron microscopy. The results confirmed that the PA6 nanocomposite showed a decrease of 8-10% in its glass-transition temperature compared to commercial PA6. The crystallinity of the synthesized samples were found to vary between 42% and 57%. The 55 wt.% oleic acid-loaded NPs were found to disperse most efficiently in the PA6 matrix; however, some large agglomerates were formed due to excessive oleic acid. Therefore, the 22 wt.% oleic acid coating showed overall superior dispersion. Additionally, the magnetic induction response was tested by observing a melt-characteristic of the magnetic polymer composite using a model setup. Oleic acid concentration is found to affect the dispersion, melting time and crystallinity of the nanocomposite.

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Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Cited by 18 publications

References 54 publications

Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study

Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study

Novel method of healing the fibre reinforced thermoplastic composite: A potential model for offshore applications

Effect of Oleic Acid Coating of Iron Oxide Nanoparticles on Properties of Magnetic Polyamide-6 Nanocomposite

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