Neuropathic pain in knee osteoarthritis

Abstract

Background This study aimed to investigate the relationship between the neuropathic pain in knee osteoarthritis with the body composition, anthropometric and postural features, physical function, and quality of life. Methods Patients with primary knee osteoarthritis, 50–70 years of age, were included in the study and divided into Group 1 with neuropathic pain and Group 2 with no neuropathic pain according to Douleur Neuropathique-4. The groups were compared in terms of demographic, clinical, radiological, laboratory findings and anthropometric measurements, body composition, physical function tests, osteoarthritis severity, quality of life, and posturography. Results 200 patients were included in the study. 98 (82.6% female) were in Group 1 and 102 (74.5% female) in Group 2. Age was higher in Group 1 compared to Group 2 [61 (50–70) and 57.5 (50–70), respectively, p = 0.03]. Symptom duration was also longer in Group 1 (5.21 ± 4.76 and 3.38 ± 3.58, p = 0.002). Body mass indices were 31.9 ± 5.6 and 30.1 ± 4.8 (p = 0.015). Kellgren–Lawrence class, Western Ontario and McMaster Osteoarthritis Index and Short Form-36 scores were more unfavorable in Group 1. Although fall risk was similar, stability and Fourier harmony indices were impaired in Group 1 compared to Group 2 especially when the visual and proprioceptive input was blocked. Conclusions Almost half of the patients with knee osteoarthritis had neuropathic pain which was associated with longer symptom duration and higher age, lower education, higher body mass index, more severe radilogical findings, worse pain perception, lower physical function and quality of life, and lower stability.

Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors

“…We observed several person-level but few foot-level differences between participants with and those without neuropathic pain. Those with neuropathic pain had worse general health (demonstrated by lower SF-12 scores) and greater pain severity, which is consistent with previous reports related to neuropathic pain in individuals with knee OA using a range of health-related quality of life measures (11,13,14) and pain assessment tools (7,8,10,15). Interestingly, we found that although pain severity at rest was higher in those with neuropathic pain, pain during walking was not.…”

Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis – a cross-sectional study

“…NS are associated with poor outcomes in knee OA such as increased pain severity, disability [ [40] , [41] , [42] ] and greater functional deficit [ 11 , 43 ]. We found a higher functional limitation in patients with knee OA and NS measured by patient's perception and objectively.…”

“…Similarly, a previous study showed that patients with knee OA who score highly on the painDETECT presented increased pain intensity and greater functional impairment than the remaining cohort [ 14 ]. Moreover, patients with knee OA and NS had longer symptom duration, lower physical function and quality of life [ 42 ]. Therefore, the presence of NS negatively impacts the functional performance of patients with knee OA.…”

Bipolar radiofrequency ablation of the superomedial (SM), superolateral (SL) and inferomedial (IM) genicular nerves for chronic osteoarthritis knee pain: a randomized double-blind placebo-controlled trial with 12-month follow-up

“…Whereas some might interpret this as evidence against performing prognostic blocks, one large retrospective study found that individuals who experienced >80% relief on GNB obtained better outcomes than those who received between 50% and 79% relief9; this suggests that our 50% cut-off threshold may have been too low. Third, we failed to exclude patients with secondary gain, mild psychopathology, sleep dysfunction, high degrees of disease burden, and the substantial proportion of subjects with possible nociplastic overlay to their KOA, all of whom are more likely to fail interventional treatments 11 28 30 39–44. We also included individuals within a wide age spectrum, as inclusivity enhances generalization.…”