The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis

Andrade, Vanessa Posener de; Souza, Fernando Henrique Carlos de; Pinto, Gustavo Luiz Behrens; Shinjo, Samuel Katsuyuki

doi:10.1186/s42358-021-00171-x

Cited by 8 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21–23 Serologically, MH associated with DM show a higher rate of positive anti-MDA5 and anti-Jo-1 antibodies, with the former portending a worse prognosis and rapid progression of lung disease. 23–26 Our patient was negative for anti-MDA5 antibody but positive for anti-KU, a myositis-associated antibody. In a series of 17 patients with anti-KU antibodies, 38% exhibited MH and 56% had ILD.…”

Section: Discussionmentioning

confidence: 80%

Mechanic Hands/Hiker Feet in a Patient With Amyopathic Dermatomyositis and Interstitial Lung Disease

Regmi

Saab‐Chalhoub

Speiser

2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

A 30-year-old African American woman with a history of interstitial lung disease presented with bilaterally symmetrical, nonpruritic, scaling and fissuring, hyperpigmented, lichenified plaques on her hands and feet. She reported occasional erythema of her face, intermittent erythema, and irritation of her eyes but denied any muscle weakness. A biopsy of the plantar first toe showed hyperkeratosis, striking alternating ortho-and parakeratosis with underlying apoptotic bodies. There was psoriasiform acanthosis without suprapapillary thinning, numerous apoptotic keratinocytes in all layers of the epidermis extending into the corneum that were out of proportion with the minimal interface inflammation. Colloidal iron and Alcian blue stains showed increased dermal mucin deposition. Given the clinical, histopathological, and supportive serological findings (positive anti-KU and anti-SSA), a diagnosis of clinically amyopathic dermatomyositis with mechanic hand/hiker feet (MH/HF) was rendered. The pseudocheckerboard pattern of MH/HF has been previously reported in only 4 patients. The most frequent associations with MH/HF are dermatomyositis and antisynthetase syndrome; however, our patient was negative for antiaminoacyl transfer RNA synthetase antibodies, a required criterion to diagnose antisynthetase syndrome. It is imperative to recognize MH/HF clinically and histopathologically because it may be an early indication of developing dermatomyositis or other connective tissue diseases, which would guide further workup and screening for systemic involvement of the disease, including interstitial lung disease.

show abstract

Section: Discussionmentioning

confidence: 80%

Mechanic Hands/Hiker Feet in a Patient With Amyopathic Dermatomyositis and Interstitial Lung Disease

Regmi

Saab‐Chalhoub

Speiser

2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Therefore, the anti-Jo-1 antibody may have a significant role in autoimmune response. In IIMs, the anti-Jo-1 antibody is most commonly involved in anti-synthetase syndrome but is also found 20–30% in polymyositis [ 37 ] and 8.5% in dermatomyositis [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Expression of Inflammatory Markers in the Muscles of Patients with Idiopathic Inflammatory Myopathy According to the Presence of Interstitial Lung Disease

Lee

Ghang

Choi

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Several studies have identified factors associated with the development of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathies (IIMs). However, few have assessed the association between ILD and muscle biopsy findings, including inflammatory marker expressions analyzed using immunohistochemistry (IHC). Methods: Muscle biopsies from patients who were newly diagnosed with IIMs between 2000 and 2017 were reviewed. ILD was diagnosed based on chest computed tomography findings at the time of diagnosis of IIMs. IHC staining was performed for CD3, CD4, CD8, CD20, CD68, CD163, MX1, MHC class I, and HLA-DR. The factors associated with the presence of ILD were evaluated by logistic regression analysis. Results: Of the 129 patients with IIM, 49 (38%) had ILD. In the muscle biopsy findings, CD4 expression, MX1 expression on immune cells, and expression of MHC class I and HLA-DR on myofibers were more common in patients with ILD than those without. In the logistic regression analysis, the HLA-DR expression on myofibers was significantly associated with the risk of ILD (OR, 2.39; 95% CI, 1.24–4.90, p = 0.012) after adjusting for pathologic findings, clinical features, and autoantibodies. Conclusion: The expression of HLA-DR on myofibers was associated with the presence of ILD in patients with IIM.

show abstract

“…Anti-Jo-1 antibodies are associated with an autoimmune condition coined "anti-synthetase syndrome", characterized by the classic triad of interstitial lung disease, myositis, polyarthritis, along with Raynaud's phenomenon, and mechanic's hand [28]. These clinical features have been observed in DM at higher rates among patients with anti-Jo-1 positivity [29]. Anti-synthetase syndrome has been observed in association with SARS-CoV-2 and COVID-19 vaccination [30].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Myositis-Specific Autoantibodies and Myositis-Associated Autoantibodies in COVID-19 Patients: A Pilot Study and Literature Review

Swartzman¹,

Gu²,

Toner³

et al. 2022

Cureus

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) infection has been linked to numerous autoimmune manifestations. Neither the mechanism nor the etiology of this association has been fully explored or elucidated. Prior studies have detected myositis in patients with proven COVID-19 infection, suggesting a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of myositis. Studies have reported elevated levels of autoimmune antibodies, including myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs), in patients with COVID-19 infection, however the prevalence is not well documented. Our objective was to assess the prevalence of MSAs and MAAs in COVID-19 patients compared with unaffected subjects. Serum samples from 74 unvaccinated, polymerase chain reaction (PCR)-positive COVID-19 infected patients were compared with serum samples from 41 healthy, unaffected individuals. All serum samples were tested for MSA and MAA reactivity. Within the COVID-19-positive group, six (8.1%) patients exhibited MSA/MAA positivity, compared with only one (2.4%) individual from the control group. Although a higher prevalence of MSA/MAA positivity was observed within the COVID-19 infected group, the difference did not reach statistical significance (p=0.223). The autoantibodies detected in this study have a unique association with dermatomyositis and other inflammatory myopathies, and may play a role in COVID-19-associated myopathy.

show abstract

The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis

Cited by 8 publications

References 25 publications

Mechanic Hands/Hiker Feet in a Patient With Amyopathic Dermatomyositis and Interstitial Lung Disease

Mechanic Hands/Hiker Feet in a Patient With Amyopathic Dermatomyositis and Interstitial Lung Disease

Expression of Inflammatory Markers in the Muscles of Patients with Idiopathic Inflammatory Myopathy According to the Presence of Interstitial Lung Disease

Prevalence of Myositis-Specific Autoantibodies and Myositis-Associated Autoantibodies in COVID-19 Patients: A Pilot Study and Literature Review

Contact Info

Product

Resources

About