Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?

Abstract

Background: To investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA). Methods: Thirty-ninepatients and 19 age, sex, body mass index matched healthy controls were included. Insulin resistance (IR) was assessed with homeostasis of model assessment-IR (HOMA-IR). Carotid intima-media thickness (CIMT) was measured at both common carotid arteries and mean CIMT was calculated. Results: The mean age was 49.50 ± 11.86 years and 64.1% were females in PsA group. In the PsA group, CIMT and HOMA-IR were significantly higher (p = 0.003, p = 0.043, respectively). AIP, AC, TG/HDL, CRI-1, CRI-2 and ca-LDL levels were similar between groups. In PsA group, CIMT was positively correlated with HOMA-IR, TG/HDL and AIP. Although ca-LDL was positively correlated with serum amyloid A (r = 0.744, p < 0.001), no correlation was detected between ca-LDL and CIMT (r = 0.215, p = 0.195). PsA patients with IR tended to have higher ca-LDL levels than patients without IR, but this difference lacked statistical significance (33.65 ± 26.94, 28.63 ± 28.06, respectively, p = 0.237). Conclusions: A significant increase in CIMT was seen in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors. CIMT was correlated with HOMA-IR, TG/HDL and AIP.

Rice bran oil could favorably ameliorate atherogenicity and insulin resistance indices among men with coronary artery disease: post hoc analysis of a randomized controlled trial

“…Moreover, other atherogenicity indicators (i.e., CRI-I and CRI-II, AC, LCI, and CHOLINDEX) that were also observed to be improved following RBO consumption after controlling for baseline levels and confounding factors within the current trial, mainly incorporate the balance between proatherogenic and anti-atherogenic lipid components. In addition, they appeared to be particularly of importance in research on developing novel agents for CVDs treatment [ 4 , 9 , 19 , 20 , 39 ].…”

“…The following formulas were applied to estimate the atherogenicity and insulin resistance indices in the current post-hoc analysis of RCT: [10,19].…”

“…Although the 2002 National Cholesterol Education Program guideline has mentioned sdLDL measurement could be considered as a complementary treatment target for patients with CAD and chronic metabolic disorders [18]; it, however, cannot be routinely assessed owing to being expensive, time-consuming, and difficult to measure [4][5][6][7][8]11]. Thus, several attempts have been made to identify surrogate markers of sdLDL and comprehensive atherosclerotic-related indices, including Castelli's risk indices I and II (CRI-I and CRI-II), lipoprotein combine index (LCI), atherogenic coefficient (AC), triglyceride to HDL-C ratio, triglyceride glucose (TyG) index, atherogenic index of plasma (AIP), and cholesterol index (CHOLINDEX) [19,20].…”

Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa

“…An increase in atherogenic indices, including LDL/HDL-C and AIP correlated with a higher risk of CVD [ 9 ]. Although AIP is more preferable atherosclerotic biochemical parameter, TC/HDL-C, and LDL/HDL-C play a key role in CVD risk assessment compared with their measurement [ 10 – 12 ]. According to EULAR report, estimation of AIP is a good biochemical marker to assess and manage the risk of CVD in RA patients [ 7 ].…”

Atherogenic indices in clinical practice and biomedical research: A short review

“…9,18,30 They were reported by William Castelli, at the end of the past century. 18 Later, many reports assessed and confirmed their positive correlation with CVD 18,24,[31][32][33] and some other conditions such as chronic obstructive pulmonary disease (COPD, negative correlation) 34 and erectile dysfunction. 35 CRI-Figure 1 The mathematical equation to calculate the AIP I has been particularly shown to reflect coronary plaques formation and the thickness of intima-media in the carotid arteries of young adults.…”