Pediatric rheumatic disease patients: time to extend the age limit of adolescence?

Silva, Clóvis A.; Terreri, M. T.; Bonfá, Eloísa; Saad‐Magalhães, Claudia

doi:10.1186/s42358-018-0031-y

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…The median of DAS28 was 2 (1.05-4.14) and 38% of JIA patients has DAS28 > 2.3. (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) vs. 17 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) years, p = 0.158] were similar in JIA patients and healthy controls. No differences were evidenced in frequencies of dysmenorrhea (62% vs. 60%, p = 0.859), menorrhagia (24% vs. 20%, p = 1.000) and premenstrual syndromes (67% vs. 75%, p = 0.538) in both groups (Table 1).…”

Section: Resultsmentioning

confidence: 89%

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Sexual function in female juvenile idiopathic arthritis patients

et al. 2019

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Objective: To evaluate sexual function female adolescents and young adults with juvenile idiopathic arthritis (JIA) and healthy controls. Methods: After exclusion, 21 female adolescent and young JIA patients and 25 healthy controls were selected for this study. Sexual function was assessed by the Sexual Quotient Questionnaire for Females (SQQ-F) score, which is a validated tool and adapted for Brazilian Portuguese language. Demographic data, JIA clinical/laboratory parameters and treatment were also assessed. Results: The median current age [26.5 (17-38.1) vs. 29.3 (19.7-35.8) years, p = 0.700)] as well as age at the first sexual activity [18 (14-30) vs. 17 (10-24) years, p = 0.158] were similar in JIA patients and healthy controls. The median of SQQ-F score was alike in both groups [75.9 (50-92) vs. 78.2 (58-94), p = 0.529], as well as frequencies of sexual dysfunction (14% vs. 12%, p = 1.000). The frequencies of all sexual domains (desire/sexual fantasies, desire/interest, arousal/foreplay, arousal/lubrication, arousal/in tune with partner, penetration/relaxation, pain/penetration, desire/involvement, orgasm and general satisfaction scores) were similar in JIA patients and healthy controls (p > 0.05). Conclusions: To our knowledge, this was the first study using a validated sexual score in a chronic arthritis population suggesting a low frequency of overall sexual dysfunction in young JIA patients. Future multicenter studies with a large sample will be necessary to confirm this finding.

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Section: Resultsmentioning

confidence: 89%

“…The cut-off age of comparison between sexual dysfunction in JIA patients was chosen according to "The Institute of Medicine and National Research Council of United States" that suggested 26 years old as the upper age limit for young adults [23].…”

Section: Discussionmentioning

confidence: 99%

Sexual function in female juvenile idiopathic arthritis patients

et al. 2019

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“…The American Academy of Pediatrics has suggested an upper age limit of 21 years for adolescence (31) . In contrast, other authors have suggested that the adolescent age should range from 10 to 25 years, based on brain growth and contemporary patterns of neurocognitive myelin synthesis, following the recommendations of the Institute of Medicine and National Research Council of the United States (32) . In the present study, we used a wide cut-off age range (13-25 years) because this period also has similar socioemotional vulnerability to biological, psychological, social, and cognitive development.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life in Adolescents and Young Adults With Inflammatory Bowel Disease Is Associated With Reduction in School and Work Productivity Rather Than Physical Impairment: A Multidisciplinary Study

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Sobrado

Damião

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: Inflammatory bowel diseases (IBD), comprising Crohn’s disease and ulcerative colitis, are chronic inflammatory diseases of the gastrointestinal tract that often have their onset among adolescents and young adults (AYA). IBD are characterized by episodes of active disease interspersed with periods of remission, and its activity is inversely correlated with health-related quality of life (HRQL). OBJECTIVE: This study aimed to determine whether AYA in remission or with low IBD activity would exhibit HRQL similar to that of age-matched healthy individuals, and whether demographic and disease factors could affect HRQL using a ‘patient-reported outcome’ instrument. METHODS: This study enrolled only AYA with IBD, with low activity. This research included five multidisciplinary clinics of two academic hospitals: Paediatric Gastroenterology, Gastroenterology, Coloproctology, Paediatric Rheumatology and Adolescent divisions, São Paulo, Brazil. A total of 59 AYA with IBD (age, 13-25 years) and 60 healthy AYA (age, 13-25 years) completed the Pediatric Quality of Life Inventory 4.0 and 36-Item Short-Form Health Survey questionnaires and the visual analogue scale (VAS) for pain. Demographic data, extra-intestinal manifestations, treatment, and outcomes regarding CD and UC were evaluated. RESULTS: AYA with IBD and healthy controls were similar with respect to median ages (18.63 [13.14-25.80] years vs 20.5 [13.68-25.84] years, P=0.598), proportion of female sex (42% vs 38%, P=0.654), and percentage of upper middle/middle Brazilian socioeconomic classes (94% vs 97%, P=0.596). The school/work score was significantly lower in AYA with IBD than in healthy controls (70 [10-100] vs 75 [5-100], P=0.037). The ‘general health-perception’ score was significantly lower in AYA with IBD than in healthy controls (50 [10-80] vs 0 [25-90], P=0.0002). The median VAS, FACES pain rating scale, and total VAS scores were similar between the two groups (2 [0-10] vs 3 [0-9], P=0.214). No association between HRQL and clinical and demographic parameters was identified among IBD patients. CONCLUSION: AYA with low IBD activity reported poor HRQL in school/work and general health perception domains, which highlights a disability criterion in this vulnerable population.

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“…There are many factors associated with non/poor adherence to drug treatment in children and adolescents with PARDs, particularly low socioeconomic status, psychological stress of parents/patients, family dysfunction, drug unavailability, insurance type and coverage, unwanted adverse events and concomitant use of more than three different types of drugs daily. 2 , 3 , 4 , 5 …”

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confidence: 99%

“…In addition, non/poor adherence to drug treatment and appointments in PARDs are more relevant issues, particularly in the second decade of life. 3 , 4 , 5 Indeed, adolescents have a set of biological, psychosocial and brain maturation developments, becoming more independent, with caregiver autonomy, peer connection, beginning of sexual and romantic relationships. 3 , 4 These findings may be delayed, exacerbated or impaired in adolescents with PARDs, contributing to low adherence to the use of immunosuppressive and biologic agents.…”

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confidence: 99%

Pediatric rheumatic disease patients: time to extend the age limit of adolescence?

Cited by 8 publications

References 6 publications

Sexual function in female juvenile idiopathic arthritis patients

Sexual function in female juvenile idiopathic arthritis patients

Health-Related Quality of Life in Adolescents and Young Adults With Inflammatory Bowel Disease Is Associated With Reduction in School and Work Productivity Rather Than Physical Impairment: A Multidisciplinary Study

Poor Adherence to Drug Treatment in Children and Adolescents With Autoimmune Rheumatic Diseases

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