Juvenile dermatomyositis: is periodontal disease associated with dyslipidemia?

Kozu, Kátia; Silva, Clóvis A.; Aikawa, Nádia E.; Pereira, Rosa Maria Rodrigues; Sallum, Adriana Maluf Elias; Savioli, Cynthia; Borba, Eduardo F.; Campos, Lúcia Maria Arruda

doi:10.1186/s42358-018-0024-x

Cited by 4 publications

(2 citation statements)

References 29 publications

(45 reference statements)

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“…Different bacteria comprised JDM signatures of oral samples; in fact, few ASVs were found in both oral and stool samples, consistent with a recent study suggesting that oral bacteria do not colonize the distal gut [44]. In the anterior subgingival dental plaque, two Fusobacterium ASVs were signi cantly enriched in JDM probands, consistent with previous studies reporting increased abundance in RA [45] and periodontal disease [46], which has been linked to JDM [47]. Additionally, posterior subgingival dental plaque from JDM probands were enriched for S. pneumoniae, which displays a plasma binding protein on its cell wall that may be immunogenic [48].…”

Section: Discussionsupporting

confidence: 89%

Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

Koester

Chow

Pepper-Tunick

et al. 2022

Preprint

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Background: Juvenile dermatomyositis (JDM) is a rare immune-mediated disease of childhood that is thought to result from genetic predisposition and environmental drivers, with documented links to microbial exposures. In this multi-center, prospective, observational cohort study, we evaluated whether JDM is associated with discrete oral and gut microbiome signatures.Methods: We generated 16S rRNA sequencing data from fecal, saliva, supragingival, and subgingival plaque samples from JDM probands (n=28, age range 3-18 years, mean age 10 years, 46% female). To control for genetic and environmental determinants of microbiome community structure to the greatest extent possible, we also profiled microbiomes of their unaffected family members (n=27 siblings, n=26 mothers, and n=17 fathers). We performed paired within-family comparisons as well as unpaired analyses of different cohorts. Results: Sample type (oral vs fecal) and nuclear family unit were the two most predominant variables explaining variance in microbiome diversity, more so than having a diagnosis of JDM. The oral and gut microbiomes of JDM probands were more similar to their own unaffected siblings than they were to the microbiomes of other JDM probands. Nonetheless, in a sibling-paired analysis, several potentially immunomodulatory bacterial taxa were differentially abundant in the microbiomes of JDM probands compared to their unaffected siblings, including Faecalibacterium in the gut and Streptococcus in the oral cavity. Further, compared to published microbiome datasets generated from healthy children and adults, fecal microbiomes of both JDM probands and their unaffected family members were markedly different. Conclusions: Family unit (which reflects the confluence of genetic and household effects) has a significant effect on microbiome community structure. Features of the dysbioses seen in oral and fecal microbiomes of JDM probands were shared by their unaffected family members, suggesting familial microbiome signatures. The loss or gain of specific fecal and oral bacteria may potentially play a role in disease pathogenesis and/or be secondary to immune dysfunction in susceptible individuals.

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Section: Discussionsupporting

confidence: 89%

Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

Koester

Chow

Pepper-Tunick

et al. 2022

Preprint

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“…The incidence is of around two to three cases/million children per year in the general population [2]. Studies have shown that JDM patients may be at increased risk of obesity [3] and of dyslipidemia [4,5], premature atherosclerosis [6] and low lean mass [7]. These findings are thought to be due to both disease-specific factors and a host of traditional risk factors that can be related to irregular physical activity [8] and bad eating habits [9].…”

Section: Introductionmentioning

confidence: 99%

Body Composition and Phase Angle: How to Improve Nutritional Evaluation in Juvenile Dermatomyositis Patients

et al. 2023

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(1) Background: This study aimed to assess body composition (BC) using bioelectrical impedance and food intake in juvenile dermatomyositis (JDM) patients. Associations between BC and physical activity, disease activity/cumulative damage and health-related quality of life parameters were also evaluated; (2) Methods: This was a cross-sectional study with 30 consecutive JDM patients (18 female and 12 male) and 24 healthy volunteers (14 female and 10 male) of both sexes followed at our pediatric rheumatology unit. The gathering of anthropometric and dietary data, and the performance of physical activity and bioelectrical impedance were undertaken in face-to-face meetings and through questionnaires. Clinical and therapeutic data were collected from medical records according to information from routine medical appointments; (3) Results: The frequency of high/very high body fat was significantly higher in controls compared with JDM patients (66.7% vs. 91.7%; p = 0.046). The median phase angle was significantly lower in patients compared with controls (5.2 ± 1.3 vs. 6.1 ± 1.0; p = 0.016). Body fat and lean mass were positively correlated with disease duration (rs = +0.629, p < 0.001 and rs = +0.716, p < 0.001, respectively) and phase angle (PhA) (rs = +0.400, p = 0.029 and rs = +0.619, p < 0.001, respectively). JDM patients with PhA ≥ 5.5 presented higher lean mass when compared with patients with PhA < 5.5 (p = 0.001); (4) Conclusions: Bioelectrical impedance can be a useful auxiliary exam in the medical and nutritional follow-up of JDM patients, because it seems to impact functional ability. These findings may assist professionals when advising JDM patients about the importance of physical activity and healthy eating in the preservation of lean mass.

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Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

Koester,

Chow,

Pepper-Tunick

et al. 2024

Sci Rep

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Juvenile dermatomyositis (JDM) is a rare immune-mediated disease of childhood with putative links to microbial exposures. In this multi-center, prospective, observational cohort study, we evaluated whether JDM is associated with discrete oral and gut microbiome signatures. We generated 16S rRNA sequencing data from fecal, saliva, supragingival, and subgingival plaque samples from JDM probands (n = 28). To control for genetic and environmental determinants of microbiome community structure, we also profiled microbiomes of unaffected family members (n = 27 siblings, n = 26 mothers, and n = 17 fathers). Sample type (oral-vs-fecal) and nuclear family unit were the predominant variables explaining variance in microbiome diversity, more so than having a diagnosis of JDM. The oral and gut microbiomes of JDM probands were more similar to their own unaffected siblings than they were to the microbiomes of other JDM probands. In a sibling-paired within-family analysis, several potentially immunomodulatory bacterial taxa were differentially abundant in the microbiomes of JDM probands compared to their unaffected siblings, including Faecalibacterium (gut) and Streptococcus (oral cavity). While microbiome features of JDM are often shared by unaffected family members, the loss or gain of specific fecal and oral bacteria may play a role in disease pathogenesis or be secondary to immune dysfunction in susceptible individuals.

show abstract

Juvenile dermatomyositis: is periodontal disease associated with dyslipidemia?

Cited by 4 publications

References 29 publications

Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

Body Composition and Phase Angle: How to Improve Nutritional Evaluation in Juvenile Dermatomyositis Patients

Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

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