Physical exercise among patients with systemic autoimmune myopathies

Oliveira, Diego Sales de; Missé, Rafael Giovani; Lima, Fernanda Rodrigues; Shinjo, Samuel Katsuyuki

doi:10.1186/s42358-018-0004-1

Cited by 12 publications

(12 citation statements)

References 45 publications

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“…Importantly, no changes were observed in the clinical and laboratory parameters after exercise training, nor there were disease relapses or exercise-related adverse events. These findings further support the notion that exercise is well tolerable and safe for patients with SAM [14] [16] [17] [18] [35].…”

Section: Discussionsupporting

confidence: 82%

“…Patients with SAM have reduced muscle strength and functional capacity [14] [16] [17] [18] [35]. Previous studies have shown that exercise training has been effective in increasing muscle strength and improving function, which correlates with an increase in quality of life [18] [36].…”

Section: Discussionmentioning

confidence: 99%

“…No que se refere às doenças autoimunes sistêmicas, vários são os estudos que mostraram a presença de rigidez arterial e disfunção endotelial nesses pacientes, bem como, observou-se em alguns estudos uma forte correlação com os parâmetros clínicos envolvidos nessas doenças, sugerindo que a doença compoe um fator idependente para doenças cardiovasculares (Soltész et al, 2009;De Groot et al, 2015). Achados mostrados em doenças como artrite reumatoide, lúpus eritematoso sistêmico, arterite de Takayasu, artrite psoriásica, síndrome de Sjögren, síndrome antifosfolipide, entre outras (Salmon e Roman, 2001;Gerli et al, 2004;Soltész et al, 2009;De Groot et al, 2015;Caraba et al, 2017 força, e a função muscular De Salles Painelli et al, 2009;Oliveira et al, 2018), observa-se melhoras sobre a função endotelial e rigidez arterial de pacientes com doenças autoimunes sistêmicas (Dos Metsios et al, 2014;Shin et al, 2015). Embora os resultados sejam motivadores, até o momento atual não há evidências sobre os potenciais efeitos de um programa de treinamento físico sobre as propriedades estruturais e funcionais de grandes vasos arteriais de pacientes com MAS.…”

Section: Lista De Tabelasunclassified

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Efeitos do treinamento físico na função endotelial e nas propriedades estruturais de grandes artérias de pacientes com miopatias autoimunes sistêmicas

Missé¹

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Lista De Tabelasunclassified

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Efeitos do treinamento físico na função endotelial e nas propriedades estruturais de grandes artérias de pacientes com miopatias autoimunes sistêmicas

Missé¹

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“…These mechanisms play important roles in the prevention of and therapy for chronic low-grade inflammation. This particularly supports a role for exercise training as a nonpharmacological therapy to improve inflammatory status in patients with systemic autoimmune myopathies [63]. Therefore, physical activity could serve as an effective strategy against the development of inflammaging associated with an increased risk of age-related diseases such as cardiovascular disease, type 2 diabetes, and autoimmune disease.…”

Section: Effects Of Exercise On Inflammagingmentioning

confidence: 60%

Physical Activity and Diet Shape the Immune System during Aging

2020

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With increasing age, the immune system undergoes a remodeling process, termed immunosenescence, which is accompanied by considerable shifts in leukocyte subpopulations and a decline in various immune cell functions. Clinically, immunosenescence is characterized by increased susceptibility to infections, a more frequent reactivation of latent viruses, decreased vaccine efficacy, and an increased prevalence of autoimmunity and cancer. Physiologically, the immune system has some adaptive strategies to cope with aging, while in some settings, maladaptive responses aggravate the speed of aging and morbidity. While a lack of physical activity, decreased muscle mass, and poor nutritional status facilitate immunosenescence and inflammaging, lifestyle factors such as exercise and dietary habits affect immune aging positively. This review will discuss the relevance and mechanisms of immunoprotection through physical activity and specific exercise interventions. In the second part, we will focus on the effect of dietary interventions through the supplementation of the essential amino acid tryptophan, n-3 polyunsaturated fatty acids, and probiotics (with a special focus on the kynurenine pathway).

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“…3) inibição, por vias pouco compreendidas, da produção, por células T efetoras, de linfocinas e quimiocinas, essenciais à perpetuação da autoimunidade (BALLOW, 1991;DWYER, 1992 Fisiologicamente, é conhecida a capacidade do exercício físico de melhorar a capacidade de oxidação completa de lipídios nos músculos esqueléticos (BERGGREN et al, 2008;DUBÉ et al, 2011;DE OLIVEIRA et al, 2018), de modular a ação de citocinas angiogênicas e angiostáticas (KOCH, 1988) MATTAR et al, 2014 [1]; NADER et al, 2010). Nader et al (NADER et al, 2010) ainda contribuíram do ponto de vista molecular, comprovando que o exercício físico é capaz de modular a expressão gênica relacionada à inflamação e fibrose, abrindo efetivamente caminho ao conceito de exercício físico como terapia.…”

Section: Masunclassified

Segurança e eficácia do exercício físico nas miopatias necrosantes imunomediadas

Souza¹

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Objectives: To describe retrospectively a case series of patients with immunemediated necrotizing myopathy (IMNM), evaluating the effects of an induction therapy with methylprednisolone (MP) associated or not with intravenous human immunoglobulin (IVIG) on late muscle condition, as seen by muscle magnetic resonance imaging, and on parameters of disease activity. Next, to evaluate prospectively the effects of an assisted and combined physical training program in this sample regarding safety, clinical status, aerobic capacity, muscle strength and function. Methods: Thirteen patients with IMNM (4 patients with anti-hydroxymethyl-glutaryl coenzyme A reductase autoantibodies and 9 patients with antisignal-recognition particle) were initially evaluated in a longitudinal analysis, from 2012 to 2018. By institutional protocol, these patients were treated at diagnosis with an induction scheme with MP pulse therapies associated or not with IVIG. The clinical and laboratory data to calculate the response criteria of the International Myositis Assessment & Clinical Study Group (IMACS) before treatment and at the end of the segment, as well as the magnetic resonance imaging of the thigh at the end of the segment, in order to assess atrophy, edema and fat replacement, were quantified. Additionally, in a quasi-experimental analysis, eight patients of the first sample were also submitted to a supervised physical training program combining aerobic and resisted exercises, twice a week, for 12 weeks. Finally, before and after the training program, the following data were compared: aerobic capacity, through cardiopulmonary exercise test; strength, through the maximal repetition test (RM) in the bench press and in the leg press; and muscular function, through the sit-tostand test (STS) and the timed up-and-go (TUG) test. Results: In the first sample, composed of 9 women and 4 men, the mean age of the patients at diagnosis was 53.5 years and the mean duration of symptoms until the diagnosis was 4 months. All patients received MP and/or IVIG therapy. After an average of 39 months of follow-up, all IMACS parameters improved significantly over baseline parameters. Nine patients had complete clinical response and, among them, two had complete remission. Eleven patients discontinued the use of glucocorticoids at the end of this phase. Only 2 patients had muscle atrophy or fat replacement classified as moderate in magnetic resonance, with the remainder presenting normal or mild findings. Eight patients in the initial sample continued the study and completed the training protocol. No disease activation, worsening of IMACS scores or adverse events were observed throughout the training period. Patients also increased aerobic capacity (time to reach the anaerobic threshold and time to achieve exhaustion), muscle strength (1 RM of the bench press) and muscle function (STS). Conclusion: In this case series, early treatment with MP and/or IVIG pulse therapy with the objective of complete clinical response may have been an effective treatment strat...

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Physical exercise among patients with systemic autoimmune myopathies

Cited by 12 publications

References 45 publications

Efeitos do treinamento físico na função endotelial e nas propriedades estruturais de grandes artérias de pacientes com miopatias autoimunes sistêmicas

Efeitos do treinamento físico na função endotelial e nas propriedades estruturais de grandes artérias de pacientes com miopatias autoimunes sistêmicas

Physical Activity and Diet Shape the Immune System during Aging

Segurança e eficácia do exercício físico nas miopatias necrosantes imunomediadas

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