Envenomation by the red-tailed coral snake (Micrurus mipartitus) in Colombia

Cañas, Carlos A.; Castro-Herrera, Fernando; Castaño-Valencia, Santiago

doi:10.1186/s40409-017-0100-4

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…For instance, the single published account of a Sinomicrurus macclellandi bite indicated that the victim felt nothing until motor issues started developing 6 h after the bite and culminated in lethal respiratory paralysis after 8 h [ 72 ]. Similarly, bites from snakes of the genus Micrurus often exhibit few symptoms besides paralysis [ 73 , 74 , 75 ].…”

Section: Introductionmentioning

confidence: 99%

Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus

Dashevsky

Rokyta

Frank

et al. 2021

Toxins

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The genus Calliophis is the most basal branch of the family Elapidae and several species in it have developed highly elongated venom glands. Recent research has shown that C. bivirgatus has evolved a seemingly unique toxin (calliotoxin) that produces spastic paralysis in their prey by acting on the voltage-gated sodium (NaV) channels. We assembled a transcriptome from C. bivirgatus to investigate the molecular characteristics of these toxins and the venom as a whole. We find strong confirmation that this genus produces the classic elapid eight-cysteine three-finger toxins, that δδ-elapitoxins (toxins that resemble calliotoxin) are responsible for a substantial portion of the venom composition, and that these toxins form a distinct clade within a larger, more diverse clade of C. bivirgatus three-finger toxins. This broader clade of C. bivirgatus toxins also contains the previously named maticotoxins and is somewhat closely related to cytotoxins from other elapids. However, the toxins from this clade that have been characterized are not themselves cytotoxic. No other toxins show clear relationships to toxins of known function from other species.

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Section: Introductionmentioning

confidence: 99%

Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus

Dashevsky

Rokyta

Frank

et al. 2021

Toxins

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“…The report of this case aims to raise some questions, the most important of which is: is it worth to classify a coral snake as non-venomous, even if you are a specialist? The Brazilian literature [ 6 , 10 , 12 , 13 ] describes accidents with coral snakes as rare, even when cases with non-venomous species are considered. Due to their non-aggressive behavior, most accidents involving coral snakes are the result of incorrect or reckless handling of these snakes, so that hands and fingers are more frequently affected [ 14 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

True or false coral snake: is it worth the risk? A Micrurus corallinus case report

Strauch

Souza

Pereira³

et al. 2018

J Venom Anim Toxins Incl Trop Dis

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BackgroundBites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus, which together represent almost 80% of accidents. In addition to their less aggressive behavior, habits and morphology of coral snakes are determinant factors for such low incidence of accidents. Although Micrurus bites are rare, victims must be rescued and hospitalized in a short period of time, because this type of envenoming may evolve to a progressive muscle weakness and acute respiratory failure.Case PresentationWe report an accident caused by Micrurus corallinus involving a 28-year-old Caucasian sailor man bitten on the hand. The accident occurred in a recreational camp because people believed the snake was not venomous. The victim presented neurological symptoms 2 h after the accident and was taken to the hospital, where he received antielapidic serum 10 h after the bite. After the antivenom treatment, the patient presented clinical evolution without complications and was discharged 4 days later.ConclusionsWe reinforce that it is essential to have a health care structure suitable for the treatment of snakebite. Besides, the manipulation of these animals should only be carried out by a team of well-equipped and trained professionals, and even so with special attention.

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“…On the one hand, at Universidad del Valle and Fundación Valle del Lilli, researchers have contributed to our knowledge about clinical manifestations of M. mipartitus and B. punctatus snakebites by informing about some clinical cases inflicted by these species (103,104). Likewise, Cañas reported a case of brainstem ischemic stroke after a B. atrox snakebite, evidencing the incidence and importance of cardiovascular complications of bothropic snakebite in Colombia (105).…”

Section: Other Researchesmentioning

confidence: 99%

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

Pereañez

Preciado

Romero

2020

Vitae

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Background: Toxinology is a field of toxicology involved in studying toxins from animals, plants and microorganisms. In Colombia, in last thirty years, this area has been mainly studied by Programa de Ofidismo/Escorpionismo of the Universidad de Antioquia, however, some other research groups have been also contributed in our knowledge of venoms, toxin, effects and treatments. Objective: highlights the most important findings in toxinology made by Programa de Ofidismo/Escorpionismo and other research groups in Colombia. Methods: we collected and analyze119 manuscripts dealing with the history of ophidiology and toxinology in Colombia. Results: we describe some useful terms to understand the toxinology and their scopes. In addition, we build a brief history of ophidiology beginning with the period corresponding to the discovery of America, and ending with recent findings. Finally, we perform a great description of several results related to toxin isolation, characterization, antivenoms, clinical trials, new species descriptions, pretoemic and transcriptomic, among other. The nineteens was characterized by the study of snakebites, their clinic manifestations and the use of antivenoms. In addition, the ethnopharmacological studies of medicinal plants used in snakebite treatments began to be explored. The 2000s included the newly ethnopharmacology, toxin isolation, clinical trials, inhibitor studies, scorpion venom characterization and scorpion stings features. Finally, from 2010 until today, proteomic and transcriptomic gave the most important findings. Conclusions: Toxinology works in Colombia have contributed in our knowledge about endemic species, clinical manifestations of snakebites and scorpion stings, however, we invite to Colciencias and other funding agencies to have more resources in order to support more researchers in this field, since, snakebite is a public neglected disease and need more attention from governments and academic people. Finally, we still have ignorance about the venoms of some species and their possible mode of action. In addition, given the complexity of venoms, we ignore the potential use of toxins in current biomedicine. Thus, we must continue performing studies in toxinology.

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Envenomation by the red-tailed coral snake (Micrurus mipartitus) in Colombia

Cited by 14 publications

References 8 publications

Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus

Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus

True or false coral snake: is it worth the risk? A Micrurus corallinus case report

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

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