Septic arthritis: immunopathogenesis, experimental models and therapy

Colavite, Priscila María; Sartori, Alexandrina

doi:10.1186/1678-9199-20-19

Cited by 50 publications

(43 citation statements)

References 65 publications

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“…In fact, the inflammatory response within the joint is the main destructive pathology and it should be treated as early as possible [21]. Modern surgical techniques offer easy and safe procedures that produce effective drainage and rapid recovery [29]. Our series provided very good results using limited arthrotomy, even though we did not provide data on articular function after the episode of pyogenic arthritis.…”

Section: Discussionmentioning

confidence: 83%

“…Nevertheless, we believe it provides some potentially clinically relevant suggestions and additional information. For example, although antibiotics should address the problem of adherent and intracellular bacteria, the most important target is planktonic bacteria [29] and should be based on routine in vitro studies of antimicrobial susceptibility [21,30]. Furthermore, schedules of 2-4 weeks appeared sufficient for most antimicrobial regimes.…”

Section: Discussionmentioning

confidence: 99%

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Pyogenic arthritis of native joints in non-intravenous drug users: A detailed analysis of 268 cases attended in a tertiary hospital over a 22-year period

Nolla

Lora‐Tamayo

Vaquero

et al. 2015

Seminars in Arthritis and Rheumatism

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Pyogenic arthritis of native joints in non-intravenous drug users: A detailed analysis of 268 cases attended in a tertiary hospital over a 22-year period

Nolla

Lora‐Tamayo

Vaquero

et al. 2015

Seminars in Arthritis and Rheumatism

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“…Mice have been considered good models for SA and OM3637, and since blood is the most frequent source of infection in humans737, efforts were made to set up and characterize an acute hematogenously-derived murine model of arthritis2528383940, with most of the reports being concentrated on observations made in the paws3637. Recently, also thanks to the great improvement in the preclinical imaging, other groups focused their attention in the field and were able to set up long lasting models of OM which evolved from an acute to a chronic phase264142.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination

Corrado

Donato

Maccari

et al. 2016

Sci Rep

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Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution and resistance to treatment. The progression of the disease depends on both bacterial presence in situ and uncontrolled disruptive immune response, which is responsible for chronic disease. Articular and bone infections are often the result of blood bacteremia, with the knees and hips being the most frequently infected joints showing the worst clinical outcome. We report the development of a hematogenous model of septic arthritis in murine knees, which progresses from an acute to a chronic phase, similarly to what occurs in humans. Characterization of the local and systemic inflammatory and immune responses following bacterial infection brought to light specific signatures of disease. Immunization of mice with the vaccine formulation we have recently described (4C-Staph), induced a strong antibody response and specific CD4+ effector memory T cells, and resulted in reduced bacterial load in the knee joints, a milder general inflammatory state and protection against bacterial-mediated cellular toxicity. Possible correlates of protection are finally proposed, which might contribute to the development of an effective vaccine for human use.Staphylococcus aureus is a human pathogen responsible for a variety of diseases ranging from minor/mild skin infections to life threatening diseases 1 . It is a major cause of bacteremia, which frequently leads to severe complications like endocarditis, toxic shock syndrome, septic arthritis (SA) and osteomyelitis (OM) 2 . Among others, joint-related diseases deserve special attention because of their rapid evolution and serious clinical outcomes, such as intense pain and impairment due to bone erosion requiring urgent intervention [3][4][5] . Joint infections are frequently localized in the knees and hips, and monoarticular disease is more frequent and less severe than polyarticular infection 6,7 . The mortality rate associated with these infections is around 5-20% in the adult population 3 , but can reach 50% depending on delayed diagnosis, immunodeficiency, older age 3,4 and pre-existing underlying conditions, such as rheumatoid arthritis and diabetes 3,8,9 . Joint and bone disruption is caused by the activity of bacteria in the joints, as well as by uncontrolled activation of the host immune system sustaining a local destructive inflammatory state, which can eventually result in chronic disease [10][11][12][13] . OM is often not treatable with antibiotics, a problem that is presently more evident with the increasing emergence of antibiotic-resistant S. aureus strains [14][15][16][17][18][19] . On the other hand, early application of antibiotic treatment can be efficacious for SA, which however often requires surgical intervention 3,4,7,20 .Given these premises, the development of an efficacious vaccine able to prevent S. aureus-mediated SA and OM would be highly desirable. We have recently demonstrated that an adjuvanted protein comb...

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“…В последние годы наблюдается явное нарастание штаммов S. aureus, устойчивых к мети-циллину (Methicillin-resistant Staphylococcus aureus -MRSA). MRSA как этиологический агент БА чаще встреча-ется у лиц, недавно выписавшихся из стационара, жителей домов престарелых, наркоманов, употребляющих внутри-венные наркотики, у пациентов с кожными язвами и дли-тельно стоящими катетерами центральных вен и т. д. Как показано в эксперименте, S. aureus обладает специфиче-скими поверхностными белками (адгезинами, фибронек-тин-связывающими протеинами), которые расцениваются как ведущие факторы вирулентности, способствующие процессу адгезии (прилипания) возбудителя к костной и хрящевой ткани [6].…”

Section: этиологияunclassified