MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Mráz, Marek; Doležalová, Dáša; Plevová, Karla; Kozubík, Kateřina Staňo; Mayerová, Veronika; Černá, Kateřina; Musilová, Kateřina; Tichý, Boris; Pavlová, Šárka; Borský, Marek; Verner, Jan; Doubek, Michael; Brychtová, Yvona; Trbušek, Martin; Hampl, Aleš; Mayer, Jiřı́; Pospı́šilová, Šárka

doi:10.1182/blood-2011-11-394874

Cited by 91 publications

(74 citation statements)

References 26 publications

(46 reference statements)

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“…Previous studies have identified several targets of miR-650, including ING4 in gastric cancer (21) and hepatocellular carcinoma (26), CDK1, ING4 and EBF3 in chronic lymphocytic leukemia (23), and CSR1 in prostate cancer (27). In this study, an important molecular association between miR-650 and LATS2 was observed in NSCLC.…”

Section: Lats2 Is Associated With the Effects Of Mir-650 In Nsclc Cellssupporting

confidence: 48%

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microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

Zhuang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Lung cancer is the most common cause of cancerassociated mortality for men and women worldwide. An increasing number of studies have reported that the abnormal expression of microRNAs contributes to the pathogenesis of the majority of human cancer types, including non-small cell lung cancer (NSCLC). The present study aimed to measure microRNA-650 (miR-650) expression in NSCLC and evaluate its function in NSCLC cells. Reverse transcription-quantitative polymerase chain reaction was used to determine miR-650 expression in NSCLC tissue samples and cell lines. Assays for cell proliferation, migration and invasion were performed to investigate the roles of miR-650 on NSCLC progression. Furthermore, the mechanisms underlying the effects of miR-650 on NSCLC cell growth and metastasis were determined. In the current study, miR-650 was demonstrated to be highly expressed in NSCLC tissue samples and cell lines. Inhibition of expression of miR-650 suppressed NSCLC cell proliferation, migration and invasion in vitro. Additionally, large tumor suppressor kinase 2 (LATS2) was identified as a direct target gene of miR-650 in NSCLC. LATS2 was revealed to be significantly downregulated in NSCLC tissues and was negatively correlated with miR-650 expression. Notably, LATS2 re-expression decreased NSCLC cell proliferation, migration and invasion; similar to the effects induced by miR-650 underexpression. In conclusion, the results of the current study suggest that miR-650 may serve as an oncogene by direct targeting LATS2 in NSCLC formation and progression.

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Section: Lats2 Is Associated With the Effects Of Mir-650 In Nsclc Cellssupporting

confidence: 48%

“…miR-650 has been studied in several types of human cancer (21)(22)(23). In this work, we measured miR-650 expression in NSCLC tissues and cell lines.…”

Section: Introductionmentioning

confidence: 99%

microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

Zhuang

Wang

et al. 2017

Experimental and Therapeutic Medicine

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“…It has been shown that immunoglobulin gene rearrangement upregulates the expression of miR-650 in chronic lymphocytic leukemia (Mraz et al, 2012). Inhibitor of Growth 4 (ING4) is a tumor suppressor and a target of miR-650 both in gastric cancer and hepatocellular carcinoma (Zhang et al, 2010;Zeng et al, 2013) .…”

Section: Mir-650mentioning

confidence: 99%

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

Farooqı

Qureshi²,

Çoşkunpınar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

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“…[11][12][13][14] In lymphoid cells, such gene-dose regulation is needed for survival and proper maturation of B and T cells, immunoglobulin production by B cells, and relative proficiency of T-cell receptor signaling in T lymphocytes. 10,12,[15][16][17][18][19] The miRNAs that regulate essential pathways in immune cells generally are abundantly expressed and evolutionarily conserved. 12,[20][21][22][23] Aberrations in such miRNA-mediated regulation were directly implicated in cancer pathogenesis (reviewed in O'Connell and Baltimore 12 ).…”

Section: Introductionmentioning

confidence: 99%

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Mráz

Chen

Rassenti

et al. 2014

Blood

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133

125

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Key Points• The most abundant miRNA in CLL, miR-150, is expressed at lower levels in cases with unfavorable clinicobiological markers and worse prognosis.• miR-150 regulates expression of genes encoding proteins that modulate BCR signaling in CLL.We examined the microRNAs (miRNAs) expressed in chronic lymphocytic leukemia (CLL) and identified miR-150 as the most abundant, but with leukemia cell expression levels that varied among patients. CLL cells that expressed z-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had a median expression level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV genes. In samples stratified for expression of miR-150, CLL cells with low-level miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 39 untranslated regions having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that enhance B-cell receptor signaling, a putative CLL-growth/ survival signal. Also, high-level expression of miR-150 was a significant independent predictor of longer treatment-free survival or overall survival, whereas an inverse association was observed for high-level expression of GAB1 or FOXP1 for overall survival. This study demonstrates that expression of miR-150 can influence the relative expression of GAB1 and FOXP1 and the signaling potential of the B-cell receptor, thereby possibly accounting for the noted association of expression of miR-150 and disease outcome. (Blood. 2014;124(1):84-95)

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MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Cited by 91 publications

References 26 publications

microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

microRNA-605 promotes cell proliferation, migration and invasion in non-small cell lung cancer by directly targeting LATS2

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

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