Comorbidities and in-hospital death of viral pneumonia adults admitted to SUS (2002–2015)

Abstract

OBJECTIVE To identify demographic and clinical characteristics of adult patients hospitalized in the Brazilian Unified Health System (SUS) due to viral pneumonia and investigate the association between some comorbidities and death during hospitalization. METHODS This retrospective cohort study was conducted with secondary data of adults admitted to SUS due to viral pneumonia between 2002 and 2015. Patient profile was characterized based on demographic and clinical variables. The association between the ten Elixhauser comorbidities and in-hospital death was investigated using Poisson regression models with robust standard errors. Results were quantified as incidence rate ratio (IRR) with 95% confidence intervals (CI), and we built five models using successive inclusion of variables blocks. RESULTS Hospital admissions for viral pneumonias decreased throughout the study period, and it was observed that 5.8% of hospitalized patients had an in-hospital death. We observed significant differences in demographic and clinical characteristics by comparing individuals who died during hospitalization with those who did not, with the occurrence of one or more comorbidities being more expressive among patients who died. Although not considered risk factors for in-hospital death, chronic pulmonary disease and congestive heart failure were the most common comorbidities. Conversely, IRR for in-hospital death increased with other neurological disorders, diabetes, cancer, obesity, and especially with HIV/AIDS. CONCLUSIONS Individuals presenting with pulmonary and cardiovascular diseases require proper attention during hospitalization, as well as those with other neurological diseases, diabetes, cancer, obesity, and especially HIV/AIDS. Understanding the influence of chronic diseases on viral infections may support the healthcare system in achieving better outcomes.

Impact of type 2 diabetes on the course and outcomes of community-acquired pneumonia in hospitalized patients

“…населения), что значительно превышает показатели прошлых лет (в 2014 году -615326 случаев) [2]. К основным факторам риска развития и тяжелого течения ВП у взрослых относят сердечнососудистые заболевания [3,4], хронические заболевания легких [5,6], а также сахарный диабет (СД) [7,8]. Оценивали демографические данные (возраст, пол, образование), данные физического исследования, результаты лабораторных и инструментальных методов исследования, эффективность стартовой эмпирической АБТ, осложнения и исходы во время госпитализации и в течение года после выписки из стационара.…”