Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy

Vale, Felipe Campos; Helena, Ernani Tiarajú de Santa; Santos, Maria Altenfelder; Carvalho, Wania Maria do Espírito Santo; Menezes, Paulo Rossi; Basso, Cáritas Relva; Silva, Mariliza Henrique da; Alves, Ana Maroso; Nemes, Maria Inês Battistella

doi:10.11606/s1518-8787.2018052000337

Cited by 15 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most extensively studied PROMs were the 8-item MMAS (MMAS-8)and 4-item MMAS(MMAS-4), which were studied in 27 and 18 studies, respectively. Among the 121 PROMs, 15 PROMs have been administered electronically—Adult AIDS Clinical Trials Group (AACTG) adherence items [ 52 ], Fredericksen et al [ 38 ], Item Response Theory-30 [ 53 ], LeastAbsolute Shrinkage and Selection Operator-10 [ 53 ], Medication Adherence Reasons Scale (MAR-Scale) [ 54 ], MAR-Scale (revised) [ 55 ], MARS [ 56 ], Medication Intake Survey-Asthma [ 57 ], MMAS-4 [ 54 ], MMAS-8 [ 58 ], Multiple Sclerosis Treatment Adherence Questionnaire [ 59 ], Probabilistic Medication Adherence Scale [ 56 ], Self-Rating Scale Item [ 52 ], visual analog scale [ 52 ], and WedAd-Q Questionnaire [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Kwan¹,

Weng²,

Loh³

et al. 2020

J Med Internet Res

View full text Add to dashboard Cite

Background Medication adherence is essential for improving the health outcomes of patients. Various patient-reported outcome measures (PROMs) have been developed to measure medication adherence in patients. However, no study has summarized the psychometric properties of these PROMs to guide selection for use in clinical practice or research. Objective This study aims to evaluate the quality of the PROMs used to measure medication adherence. Methods This study was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Relevant articles were retrieved from the EMBASE, PubMed, Cochrane Library, Web of Science, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases. The PROMs were then evaluated based on the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Results A total of 121 unique medication adherence PROMs from 214 studies were identified. Hypotheses testing for construct validity and internal consistency were the most frequently assessed measurement properties. PROMs with at least a moderate level of evidence for ≥5 measurement properties include the Adherence Starts with Knowledge 20, Compliance Questionnaire-Rheumatology, General Medication Adherence Scale, Hill-Bone Scale, Immunosuppressant Therapy Barrier Scale, Medication Adherence Reasons Scale (MAR-Scale) revised, 5-item Medication Adherence Rating Scale (MARS-5), 9-item MARS (MARS-9), 4-item Morisky Medication Adherence Scale (MMAS-4), 8-item MMAS (MMAS-8), Self-efficacy for Appropriate Medication Adherence Scale, Satisfaction with Iron Chelation Therapy, Test of Adherence to Inhalers, and questionnaire by Voils. The MAR-Scale revised, MMAS-4, and MMAS-8 have been administered electronically. Conclusions This study identified 121 PROMs for medication adherence and provided synthesized evidence for the measurement properties of these PROMs. The findings from this study may assist clinicians and researchers in selecting suitable PROMs to assess medication adherence.

show abstract

Section: Resultsmentioning

confidence: 99%

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Kwan¹,

Weng²,

Loh³

et al. 2020

J Med Internet Res

View full text Add to dashboard Cite

show abstract

“…In addition, we should note that the WebAd-Q may not be a direct measure of individual nonadherence. However, it has been shown to be associated with viral load (i.e., indicators of nonadherence were associated with higher viral load) and with traditional adherence measures [ 34 ] and, thus, can be considered a robust and valid tool for screening nonadherence in HIV care facilities in Brazil. Finally, although the patients answered the WebAd-Q anonymously, adherence measures collected in a standardized research protocol may not entirely correspond to measures obtained in routine care, and additional data should be obtained to corroborate the findings, including CD4+ cell counts, viral load, and ARV resistance assays.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment adherence was assessed using the WebAd-Q , a previously validated self-reported tool developed to monitor an overall measure of adherence in Brazilian public HIV care facilities. [ 34 ] Two healthcare providers from each selected facility participated in a 1-day training regarding the patients’ recruitment process and invitation to participate in the study according to standardized procedures. Patients selected for the first component answered to the WebAd-Q in private rooms in the healthcare facilities, and no personal data were collected.…”

Section: Methodsmentioning

confidence: 99%

“…To address this gap, a self-reported tool to monitor ART and screen for potential nonadherence in the Brazilian public HIV care facilities has been recently developed and validated—the Qualiaids Web Adherence Questionnaire ( WebAd-Q ). [ 34 ] The WebAd-Q was developed to be a practical tool for routine use, capable of addressing different dimensions of adherence, that is, scheduling, drug regimen, and dose. In the validation study, the WebAd-Q measures were associated with viral load, and performed well in comparison to concurrent measures (i.e., electronic monitoring, pill counting, self-report interview).…”

Section: Introductionmentioning

confidence: 99%

“…In the validation study, the WebAd-Q measures were associated with viral load, and performed well in comparison to concurrent measures (i.e., electronic monitoring, pill counting, self-report interview). [ 34 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monitoring self-reported adherence to antiretroviral therapy in public HIV care facilities in Brazil

et al. 2018

Self Cite

View full text Add to dashboard Cite

Introduction:Patient adherence to antiretroviral therapy (ART) is critical for HIV treatment success. Monitoring rates of adherence in public HIV outpatient care facilities can improve outcomes in Brazil where ART is universally available.Methods:We conducted a national cross-sectional survey of ART adherence in 2010. Participants were selected using a multistage probability sample. First, HIV outpatient care facilities were stratified according to 7 Organizational Quality Classification (OQC) groups and regions. Second, 1 or 2 facilities were selected per region for each OQC group. Finally, patients were randomly selected at each facility. In a first component, patients were invited to answer to a web-based questionnaire (WebAd-Q), a validated self-reported tool that includes 3 questions on adherence to ART in the past 7 days (time scheduling—timing, drug regimen—medication, and pill counts—dose), herein named indicators of potential nonadherence (IPN). In addition, a subsample of participants were interviewed in order to obtain further data on sociodemographic and clinical characteristics (second component). The proportion of each IPN was estimated using weighted data to account for the sampling design with 95% confidence interval (CI) and descriptive analysis was carried out.Results:Fifty-five facilities were chosen and 2424 patients completed the WebAd-Q in the first component of the study, while 598 patients were interviewed for the second component. The weighted proportions of the IPN were 50.9%, 31.8%, and 19.5%, for timing, medication, and dose, respectively, while11.7% had all 3 indicators, varying from 5.9% in the Southeast and 21.9% in the Northeast regions. Overall, 61.1% of the patients had at least 1 IPN (95% CI: 58.5–63.7%). Patients reporting depression symptoms, illicit drug use and those who missed medical appointments had worse nonadherence outcomes.Conclusions:Overall, there was a high proportion of all indicators IPN and timing was the main component associated with low adherence. Although these indicators may not necessarily indicate individual nonadherence, they represent a worrisome scenario in the public Brazilian HIV care facilities. On a routine basis, these facilities can identify gaps in providing counseling and ART orientation to their clientele and develop innovative strategies to prevent nonadherence.

show abstract

Knowledge of HIV transmission, prevention strategies and U = U among adult sexual and gender minorities in Brazil

Silva,

Ferreira,

Coelho

et al. 2024

J Int AIDS Soc.

View full text Add to dashboard Cite

IntroductionAlthough strong scientific evidence of the efficacy and effectiveness of treatment‐as‐prevention (TasP) is available, full endorsement of the “Undetectable = Untransmittable” (U = U) and “zero‐risk” messages could be improved. Increasing knowledge about HIV transmission, prevention and treatment is a critical component of care efforts. The study assessed knowledge of HIV transmission and prevention strategies, and the perceived accuracy of the slogan U = U among sexual and gender minorities (SGM) in Brazil.MethodsCross‐sectional web‐based survey targeting adult SGM living in Brazil (2021−2022) recruited on social media and dating apps. We used the 12‐item HIV Knowledge Assessment (HIV‐KA) questionnaire to assess HIV knowledge, three items of which address pre‐exposure prophylaxis (PrEP), post‐exposure prophylaxis and TasP. Perceived accuracy of the U = U slogan was assessed with the question: “With regards to HIV‐positive individuals transmitting HIV through sexual contact, how accurate do you believe the slogan U = U is?”. We a priori grouped the study population into three mutually exclusive groups: people living with HIV (PLHIV), HIV negative and HIV unknown. We used logistic regression models to assess factors associated with high HIV knowledge and perception of the U = U as completely accurate.ResultsOf 50,222 individuals accessing the questionnaire, 23,981 were included: 5071 (21.0%) PLHIV, 17,257 (71.5%) HIV negative and 1653 (6.9%) HIV unknown. The proportion of participants with high knowledge was significantly higher for PLHIV and HIV negative (48.1% and 45.5%, respectively) compared to 26.1% of HIV unknown. More PLHIV perceived U = U as completely accurate (80.4%), compared to 60.0% of HIV negative and 42.9% of HIV unknown. HIV knowledge correlates with perceived accuracy of the U = U slogan across all groups. Higher HIV knowledge was associated with higher income and education regardless of HIV status. Among HIV‐negative participants, PrEP awareness and use were associated with higher knowledge and accurate perception of the U = U slogan.ConclusionsOur findings show that HIV knowledge and perceived accuracy of U = U are strongly correlated, that knowledge differs according to HIV status, and that poor socio‐economic is linked to poor knowledge among SGM from Brazil. Educational strategies regarding TasP, U = U and zero risk targeting socio‐economically vulnerable populations are urgent in Brazil.

show abstract

Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy

Cited by 15 publications

References 23 publications

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Measurement Properties of Existing Patient-Reported Outcome Measures on Medication Adherence: Systematic Review

Monitoring self-reported adherence to antiretroviral therapy in public HIV care facilities in Brazil

Knowledge of HIV transmission, prevention strategies and U = U among adult sexual and gender minorities in Brazil

Contact Info

Product

Resources

About