&lt;i&gt;Chlamydia trachomatis&lt;/i&gt; Pathogenicity and Disease

Dean, Deborah

doi:10.1159/000348751

Cited by 7 publications

(4 citation statements)

References 255 publications

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“…Chlamydia trachomatis ( Ct ) is a Gram‐negative bacterium of humans that is the leading cause of bacterial sexually transmitted diseases and preventable blindness worldwide (Centers for Disease Control and Prevention, ; Dean, ). The obligate intracellular nature of the organism has limited our ability to completely understand the complex host‐pathogen interactions that allow it to survive and replicate within a diversity of host cells.…”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatisregulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets

Sharma

Recuero-Checa

Fan

et al. 2017

Cellular Microbiology

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Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular pathogen of humans that causes significant morbidity from sexually transmitted and ocular diseases globally. Ct acquires host fatty acids (FA) to meet the metabolic and growth requirements of the organism. Lipid droplets (LDs) are storehouses of FAs in host cells and have been proposed to be a source of FAs for the parasitophorous vacuole, termed inclusion, in which Ct replicates. Previously, cells devoid of LDs were shown to produce reduced infectious progeny at 24 hr postinfection (hpi). Here, although we also found reduced progeny at 24 hpi, there were significantly more progeny at 48 hpi in the absence of LDs compared to the control wild-type (WT) cells. These findings were confirmed using transmission electron microscopy where cells without LDs were shown to have significantly more metabolically active reticulate bodies at 24 hpi and significantly more infectious but metabolically inert elementary bodies at 48 hpi than WT cells. Furthermore, by measuring basal oxygen consumption rates (OCR) using extracellular flux analysis, Ct infected cells without LDs had higher OCRs at 24 hpi than cells with LDs, confirming ongoing metabolic activity in the absence of LDs. Although the FA oleic acid is a major source of phospholipids for Ct and stimulates LD synthesis, treatment with oleic acid, but not other FAs, enhanced growth and led to an increase in basal OCR in both LD depleted and WT cells, indicating that FA transport to the inclusion is not affected by the loss of LDs. Our results show that Ct regulates inclusion metabolic activity and growth in response to host FA availability in the absence of LDs.

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Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatisregulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets

Sharma

Recuero-Checa

Fan

et al. 2017

Cellular Microbiology

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“…Lack of or inadequate STI testing along with high proportions of asymptomatic infection-up to 80% for chlamydia and 50% for gonorrhea among males and females, respectively-have led to many undiagnosed and untreated cases [8][9][10][11]. These untreated STIs can lead to serious health consequences including pelvic inflammatory disease (PID), infertility, ectopic pregnancy, and preterm birth, as well as the burdens of treatment costs, lost wages from illness, psychosocial disruption of families, and increased risk of HIV [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Chlamydial and gonorrheal neglected sexually transmitted diseases among Pacific Islanders of the Western Pacific Region—A narrative review and call to action

et al. 2023

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The Pacific Island countries of the Western Pacific Region have some of the highest rates of sexually transmitted Chlamydia trachomatis and Neisseria gonorrhoeae infections in the world. Despite this, there are few research studies that include Pacific Islanders. We conducted a narrative review of original research and surveys, including World Health Organization and Pacific Community reports, to determine the prevalence, management, and treatment of C. trachomatis and N. gonorrhoeae compared to HIV and syphilis from 1980 to 2022. Available epidemiologic data on C. trachomatis and N. gonorrhoeae indicated an extremely high prevalence—approximately 30% and 13%, respectively—among Pacific Islanders during this timeframe. These neglected sexually transmitted infections represent a significant burden and health disparity. Robust epidemiologic research is needed to identify modifiable risk factors for designing interventions and control strategies. Appropriate policies along with regional and international advocacy and aid are required to improve reproductive health among these vulnerable, understudied populations to avert preventable infections and sequelae.

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“…C. trachomatis infection can present with non-specific symptoms of dysuria, vaginal or urethral discharge, lower abdominal pain, and/or dyspareunia [9]. However, approximately 80% of women and 50% of men are asymptomatic [10,11], creating a challenge for infection control and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…This is complicated by the fact that the WHO recommends syndromic management, which relies primarily on signs and symptoms, in low-income and low-resource settings [12]. Undiagnosed and therefore untreated C. trachomatis can lead to pelvic inflammatory disease, ectopic pregnancy, chronic pelvic pain, infertility and adverse pregnancy outcomes in addition to an increased risk of cervical cancer and HIV [9,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

et al. 2020

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Background Chlamydia trachomatis is the most common bacterial sexually transmitted infection worldwide with some of the highest prevalence rates among Pacific Island Countries where syndromic management is practiced. However, little is known about the true prevalence and risk indicators for infection among neglected populations in these countries that suffer from health disparities. Methodology/Principal findings Consecutive sampling was used to enroll sexually active females, aged 18-40 years, attending 12 Fijian Ministry of Health and Medical Services Health Centers and outreach locations from February to December, 2018. A Behavioral Surveillance Survey was administered to assess risk indicators for infection. Signs and symptoms were recorded, and vaginal swabs were tested for C. trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Candida and bacterial vaginosis. Bivariate and multivariate logistic regression analyses were performed using R-Studio. Of 577 participants, 103 (17.85%) were infected with C. trachomatis of whom 80% were asymptomatic and only 11 met criteria for syndromic management; 38.8% of infected women were 18-24 years old with a prevalence of 30.5%. 91.7% of participants intermittently or did not use condoms. C. trachomatis infection was associated with iTaukei ethnicity (OR 21.41 [95% CI: 6.38-133.53]); two lifetime partners (OR 2.12

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<i>Chlamydia trachomatis</i> Pathogenicity and Disease

Cited by 7 publications

References 255 publications

Chlamydia trachomatisregulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets

Chlamydia trachomatisregulates growth and development in response to host cell fatty acid availability in the absence of lipid droplets

Chlamydial and gonorrheal neglected sexually transmitted diseases among Pacific Islanders of the Western Pacific Region—A narrative review and call to action

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

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