Topical eicosapentaenoic acid (EPA) in the treatment of psoriasis

1‐Tetradecanol Complex Reduces Progression of Porphyromonas gingivalis–Induced Experimental Periodontitis in Rabbits

“…Although improvement in some clinical parameters has been shown, especially in gingival index and bleeding index, the results could not conclude that systemic administration of omega‐3 PUFA were effective in preventing experimental gingivitis 25 . Because of the high epithelial penetration ability of fatty acids, 26 local application may be a better route for treatment of oral inflammatory diseases than dietary supplementation 27 and in experimental periodontitis in animal models 28‐30,51 …”

“…On the other hand, the high epithelial penetration ability of fatty acids 26 makes it probable that local application is useful for the treatment of local oral inflammatory diseases. Indeed, topical application of omega‐3 PUFA has been shown to be successful in the treatment of other inflammatory diseases, such as psoriasis, 27 as well as experimental periodontitis in animal models 28‐30 …”

1‐Tetradecanol Complex: Therapeutic Actions in Experimental Periodontitis

“…Fatty acids have been proposed to reduce chronic inflammation in individuals with arthritis by reducing the release of LTB 4 from stimulated neutrophils and interleukin‐1 from monocytes 13–15 . The topical application of omega‐3 (ω‐3) polyunsaturated fatty acid (PUFA) was successful in the treatment of inflammatory diseases, such as psoriasis, as well as experimental periodontitis in animal models by decreasing leukocyte chemotaxis, adhesion molecule expression, and inflammatory cytokine production 16–18 . Offenbacher et al 19 showed that eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) can inhibit the production of PGE 2 to an extent similar to ibuprofen when added to human periodontal homogenates.…”

Local application of n−3 or n−6 polyunsaturated fatty acids in the treatment of human experimental gingivitis

“…The high epithelial penetration ability of fatty acids (Tanojo et al 1997) makes it quite probable that the local application may be more favorable for the treatment of oral inflammatory diseases than dietary supplementation. Topical application has already been used successfully in the treatment of other inflammatory diseases (Dewsbury et al 1989). Based on these data the objective for the following clinical study was to determine if any beneficial effect would arise from the local application of n −3 or n −6 fatty acids for the prevention or resolution of experimental gingival inflammation.…”