On-chip magnetic field modulation for distributed immunomagnetic detection of circulating tumor cells

Chen, Peng; Huang, Yun; Hoshino, Kazunori; Zhang, Xiaojing

doi:10.1109/transducers.2013.6626989

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…When the permanent magnet is the sole source of magnetic field, the largely uneven distribution of the magnetic field causes the aggregation of nanoparticles, causing 90% of the cells to be captured at the front edge of the permanent magnet 11 . This poses a problem because the dense aggregation of nanoparticles and cells in one place may damage fragile CTCs during the separation process.…”

Section: Separation With Zero-dimensional Nanostructures: Nanopartmentioning

confidence: 99%

“…With the integration of nanomagnets into the microfluidic channel, the nanoparticles’ adherence pattern disperses and the channel usage increases by 23%. In addition, the nanomagnets decreased the degree of nanoparticle aggregation by 20%, suggesting that this system reduces the amount of excess nanoparticles which could hinder analysis 11 . It is noted that the nanomagnets must be thin as to limit collision and consequent damage to the CTCs in the microfluidic channel 10 .…”

Section: Separation With Zero-dimensional Nanostructures: Nanopartmentioning

confidence: 99%

“…(c) Addition of nanomagnet arrays on the capture glass slide at varying densities enhances localized magnetic fields, leading to a more uniform distribution of the field and again reduces nanoparticle aggregation. Figure adapted from reference 11.…”

Section: Figurementioning

confidence: 99%

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Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection

Chen

Hang

et al. 2015

Ann Biomed Eng

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Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a fast growing set of clinical tools for medicine. Emerging multi-dimensional nanostructures, when coupled with microfluidics, enable effective and efficient screening with high specificity and sensitivity, both of which are important aspects of biological detection systems. In this review, we provide an overview of current research and technologies that utilize nanostructures to facilitate biological separation in microfluidic channels. Various important physical parameters and theoretical equations that characterize and govern flow in nanostructure-integrated microfluidic channels will be introduced and discussed. The application of multi-dimensional nanostructures, including nanoparticles, nanopillars, and nanoporous layers, integrated with microfluidic channels in molecular and cellular separation will also be reviewed. Finally, we will close with insights on the future of nanostructure-integrated microfluidic platforms and their role in biological and biomedical applications.

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Section: Separation With Zero-dimensional Nanostructures: Nanopartmentioning

confidence: 99%

Section: Separation With Zero-dimensional Nanostructures: Nanopartmentioning

confidence: 99%

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Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection

Chen

Hang

et al. 2015

Ann Biomed Eng

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“…The patterned array not only helped increase the capture rate, but also distributed the cells to make full usage of the space inside the channel. 74,92 To combine the micromagnet with the immunomagnet CTC detection assay, the fundamental requirement is to enhance local magnetic force to facilitate surface cell retaining. Additionally, an appropriate micromagnet system should (1) minimize possible physical damage to the target cells inside the microchannel; (2) reduce the aggregation of cells and free nanoparticles; (3) provide retrievable cells after capture for subsequent cellular imaging and downstream molecular studies; and (4) have robust fabrication processes so we can scale up for mass production.…”

Section: Micromagnet-based Designs and Applicationsmentioning

confidence: 99%

Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

Chen

Hoshino

et al. 2014

Lab Chip

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We review the rare cancer cell sorting technologies, with a focus on multiscale immunomagnetic approaches. Starting from the conventional magnetic activated cell sorting system, we derive the scaling laws of immunomagnetic assay and justify the recent trend of using downscaled systems for CTC studies. Furthermore, we introduce recent work on combining the immunomagnetic assay with microfluidic technology for enhanced separation. We summarize different types of in-channel micro-magnetic structures that can further increase the local magnetic field without lowering the system throughput. Related design concepts, principles, and microfabrication techniques are presented and evaluated.

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On-chip magnetic field modulation for distributed immunomagnetic detection of circulating tumor cells

Cited by 2 publications

References 10 publications

Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection

Multi-Dimensional Nanostructures for Microfluidic Screening of Biomarkers: From Molecular Separation to Cancer Cell Detection

Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

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