Causation of Neural Tube Defects: Clues From Epidemiology

Leck, Ian

doi:10.1093/oxfordjournals.bmb.a071187

Cited by 134 publications

(58 citation statements)

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“…'Anencephalics' with their variable viability would require from one to four a alleles for survival and their greater female excess at birth would be particularly marked among the more severely deformed. These predictions correlate closely with previous observations (Leck, 1972(Leck, , 1974Rogers and Morris, 1973). The 'all female' epidemic may have been a group of anencephalics so severely deformed that only the presence of four a alleles could permit survival to birth.…”

Section: Introductionsupporting

confidence: 89%

May spina bifida result from an X-linked defect in a selective abortion mechanism?

Burn¹,

Gibbens²

1979

Journal of Medical Genetics

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Section: Introductionsupporting

confidence: 89%

May spina bifida result from an X-linked defect in a selective abortion mechanism?

Burn¹,

Gibbens²

1979

Journal of Medical Genetics

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“…Spina bifida cystica cases comprised 22 cases (88%) of myelomeningocele, and three (12%) cases of meningocele. The sites of the lesions were cervical (4), dorsolumbar (13), lumbar (1), lumbosacral (5), and sacral (2). This indicates that lumbar involvement was indicated in 72% of our cases (Table 2).…”

Section: Resultsmentioning

confidence: 70%

Neural Tube Defects in Southwestern Region of Saudi Arabia

El-Awad

Sivasankaran

1992

Ann Saudi Med

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“…38 Such a low prevalence may not reflect the true folate status of these women; the basis for such speculation is the high prevalence of iron deficiency. Iron deficiency may mask folate deficiency.…”

Section: Discussionmentioning

confidence: 99%

Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: a probabilistic national survey

et al. 2003

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Objective. To describe the epidemiology of Vitamin A and C and folic acid deficiencies and their association with sociodemographic and dietary factors in a national probabilistic sample of Mexican women and children. Material and Methods. This is a probabilistic sample from the National Nutrition Survey 1999 (ENN-99) including 1 966 children and 920 women. Vitamins A and C were measured in serum by high-performance liquid chromatography, and folic acid in total blood by a microbiological method. Determinants for such deficiencies were explored by multiple regression models. Results. Vitamin A deficiency (retinol <10 µg/dl) was rare in both children and women. But subclinical deficiency (retinol >10 and <20 µg/dl) was present in 25% of children. The likelihood of subclinical deficiency of vitamin A was less in older children (OR=0.98, p=0.01) and in women with higher body mass index (OR=0.93, p=0.01). About 30% of children <2 years of age and 40% of women were vitamin C deficient. The likelihood of vitamin C deficiency was less in children and women as socioeconomic level increased (OR=0.69, p=0.03, and OR=0.80, p=0.04), and higher in older women (OR=1.02, p=0.05). The prevalence of folate deficiency varied in children (2.3 to 11.2), in women it was 5%. Folate deficiency was less in children of higher socioeconomic level (OR=0.62, p=0.01 ), and in those eating more vegetables (OR= 0.22, p=0.01

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Causation of Neural Tube Defects: Clues From Epidemiology

Cited by 134 publications

References 0 publications

May spina bifida result from an X-linked defect in a selective abortion mechanism?

May spina bifida result from an X-linked defect in a selective abortion mechanism?

Neural Tube Defects in Southwestern Region of Saudi Arabia

Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: a probabilistic national survey

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