Structure formation of surfactant membranes under shear flow

Shiba, Hayato; Noguchi, Hiroshi; Gompper, Gerhard

doi:10.1063/1.4811239

Cited by 8 publications

(7 citation statements)

References 61 publications

(95 reference statements)

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“…For instance, the self-assembly of phosphatidylcholine (PC), cholesterol, and various cosurfactants resulted in an almost identical structure to those in the cryo-TEM images reported herein but coexisting with mainly individual multilamellar vesicles (28). Multilamellar bodies in biological systems have also exhibited structures almost identical to those reported herein, suggesting the possible utility of JDSs as models (29,30).…”

Section: Resultssupporting

confidence: 69%

“…On the other hand, in the right image, in which the dumbbell assembly is squeezed within the lacey carbon architecture of the cryo-TEM grid, it is more difficult to clearly distinguish the membranes of each vesicle from each other. The outer membrane of the left vesicle even appears to cross over to the right vesicle in a manner suggestive of a disclination (26)(27)(28) in which a single membrane diverges into two (see bottom center of Fig. 5D).…”

Section: Resultsmentioning

confidence: 99%

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Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

Xiao

Sherman

Wilner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

200

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A three-component system of Janus dendrimers (JDs) including hydrogenated, fluorinated, and hybrid hydrogenated-fluorinated JDs are reported to coassemble by film hydration at specific ratios into an unprecedented class of supramolecular Janus particles (JPs) denoted Janus dendrimersomes (JDSs). They consist of a dumbbellshaped structure composed of an onion-like hydrogenated vesicle and an onion-like fluorinated vesicle tethered together. The synthesis of dye-tagged analogs of each JD component enabled characterization of JDS architectures with confocal fluorescence microscopy. Additionally, a simple injection method was used to prepare submicron JDSs, which were imaged with cryogenic transmission electron microscopy (cryo-TEM). As reported previously, different ratios of the same three-component system yielded a variety of structures including homogenous onion-like vesicles, core-shell structures, and completely self-sorted hydrogenated and fluorinated vesicles. Taken together with the JDSs reported herein, a self-sorting pathway is revealed as a function of the relative concentration of the hybrid JD, which may serve to stabilize the interface between hydrogenated and fluorinated bilayers. The fission-like pathway suggests the possibility of fusion and fission processes in biological systems that do not require the assistance of proteins but instead may result from alterations in the ratios of membrane composition.Janus particles | onion-like vesicles | self-sorting | fusion mechanism J anus particles (JPs) are nanoscale or microscale objects that exhibit two-faced asymmetry, enabling the presentation of vastly different chemical or physical properties localized at distinct parts of the same structure. They have been prepared as unimolecular systems in the form of dendrimers, dendrimer-like polymers, heterografted polymers, and polyhedral oligomeric silsesquioxanes; as supramolecular assemblies from lipids, block copolymers, and terpolymers and other polymers; as liquid crystals; and as inorganic nanoparticles. JPs have gained increasing attention due to their application in a variety of fields including as emulsion stabilizers, facilitators for the development of novel liquid/liquid and liquid/air interfaces among other interfacial applications, optical nanoprobes, electronic inks, self-propelling beads, targeted stealth drug delivery systems, MRI contrast agents, and theranostics agents, among other biomedical applications (1).Asymmetric molecules such as phospholipids, block copolymers, and Janus dendrimers (JDs) can be thought of as the molecularlevel equivalent of JPs. Phospholipids are the major building block of the bilayers of biological membranes. Synthetic vesicles, which mimic biological membranes, have been prepared from phospholipids and are denoted liposomes. As the result of their instability due to oxidation, phospholipids must be coassembled with cholesterol and polyethylene glycol-conjugated phospholipids to form stable liposomes (2, 3). Furthermore, time-consuming fractionation and extrusio...

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Section: Resultssupporting

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

Xiao

Sherman

Wilner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

200

View full text Add to dashboard Cite

show abstract

“…We note that the correlation-corrected ion densities (20) are fully characterized by the potentials (21), (27) and (29). One also sees that these functions depend solely on the parameters s and Γ.…”

Section: Ionic Correlations and Charge Reversal At Planar Inter-mentioning

confidence: 68%

“…These examples were selected as they allow us to convey the main insights about correlation effects that can be gained from the variational approach, and in conjunction with ions of higher valency, where PB-theory is known to fail. Further applications of the equations in the case of a dielectric continuum concern the effect of image charges on macro-ions [19] and on the electrical double layer [20,21]. The ion size effects upon ionic exclusion from dielectric interfaces and slit nanopores were treated in [22][23][24].…”

Section: The Variational Equations For a Dielectric Continuummentioning

confidence: 99%

Beyond Poisson–Boltzmann: fluctuations and fluid structure in a self-consistent theory

Buyukdagli

Blossey

2016

J. Phys.: Condens. Matter

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Poisson-Boltzmann (PB) theory is the classic approach to soft matter electrostatics which has been applied to numerous problems of physical chemistry and biophysics. Its essential limitations are the neglect of correlation effects and of fluid structure. Recently, several theoretical insights have allowed the formulation of approaches that go beyond PB theory in a systematic way. In this topical review we provide an update on the developments achieved in self-consistent formulations of correlation-corrected Poisson-Boltzmann theory. We introduce the corresponding system of coupled nonlinear equations for both continuum electrostatics with a uniform dielectric constant and a structured solvent, a dipolar Coulomb fluid, including nonlocal effects. While the approach is only approximate and also limited to corrections in the so-called weak fluctuation regime, it allows to include physically relevant effects, as we show for a range of applications of these equations.

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“…In this case, unilamellar vesicles instead of MLVs would be induced as was suggested by a theoretical study. 31 The shoulder seen in the viscosity data ( Fig. 8) may come from this type of structural change.…”

Section: Structure Under Shear Flowmentioning

confidence: 93%

Effect of interlamellar interactions on shear induced multilamellar vesicle formation

Kawabata

Bradbury

Kugizaki

et al. 2017

The Journal of Chemical Physics

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Shear-induced multilamellar vesicle (MLV) formation has been studied by coupling the small-angle neutron scattering (SANS) technique with neutron spin echo (NSE) spectroscopy. A 10% mass fraction of the nonionic surfactant pentaethylene glycol dodecyl ether (CE) in water was selected as a model system for studying weak inter-lamellar interactions. These interactions are controlled either by adding an anionic surfactant, sodium dodecyl sulfate, or an antagonistic salt, rubidium tetraphenylborate. Increasing the charge density in the bilayer induces an enhanced ordering of the lamellar structure. The charge density dependence of the membrane bending modulus was determined by NSE and showed an increasing trend with charge. This behavior is well explained by a classical theoretical model. By considering the Caillé parameters calculated from the SANS data, the layer compressibility modulus B¯ is estimated and the nature of the dominant inter-lamellar interaction is determined. Shear flow induces MLV formation around a shear rate of 10 s, when a small amount of charge is included in the membrane. The flow-induced layer undulations are in-phase between neighboring layers when the inter-lamellar interaction is sufficiently strong. Under these conditions, MLV formation can occur without significantly changing the inter-lamellar spacing. On the other hand, in the case of weak inter-lamellar interactions, the flow-induced undulations are not in-phase, and greater steric repulsion leads to an increase in the inter-lamellar spacing with shear rate. In this case, MLV formation occurs as the amplitude of the undulations gets larger and the steric interaction leads to in-phase undulations between neighboring membranes.

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Structure formation of surfactant membranes under shear flow

Cited by 8 publications

References 61 publications

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

Beyond Poisson–Boltzmann: fluctuations and fluid structure in a self-consistent theory

Effect of interlamellar interactions on shear induced multilamellar vesicle formation

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