Psoriasis Therapy -- Observational or Rational?

Krueger, Gerald G.

doi:10.1056/nejm199306243282511

Cited by 11 publications

(3 citation statements)

References 9 publications

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“…However, many of the possible mechanisms and pathways are still being discussed in the scienti® c community. Some authors assert the concept of autoimmunity (14), where the patient's immune system reacts inadequately against his/her own tissues, as if they were a foreign pathogen. However, many other authors dispute this hypothesis (15 ± 17).…”

Section: Discussionmentioning

confidence: 99%

Subclinical Microbial Infection in Patients with Chronic Plaque Psoriasis

Bartenjev¹

2000

Acta Dermato-Venereologica

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Epidemiological evidence implicates bacterial infection as a common triggering stimulus for psoriasis. Recent studies suggest that continuing, subclinical streptococcal and staphylococcal infections might be responsible not only for relapse of acute guttate psoriasis but also for a new episode of chronic plaque psoriasis. In this study 195 patients suffering from a severe form of chronic plaque psoriasis hospitalized between 1996 and 1998 were examined. The presence of subclinical microbial infection of the upper respiratory tract was studied by the cultivation of pathogens from this area. Patients with other provoking factors, such as a positive history of taking any drugs that may exacerbate psoriasis, endocrine and metabolic factors, alcohol abuse, trauma, dental focus and clinically evident bacterial infection, were excluded. Subclinical streptococcal and/or staphylococcal infections were detected in 68% of tested patients and in only 11% of the control group. The results of this study indicate that subclinical bacterial infections of the upper respiratory tract may be an important factor in provoking a new relapse of chronic plaque psoriasis. Searching for, and eliminating, microbial infections could be of importance in the treatment of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Subclinical Microbial Infection in Patients with Chronic Plaque Psoriasis

Bartenjev¹

2000

Acta Dermato-Venereologica

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“…In that review, 29% of the patients claimed that their psoriasis went into remission without physiciandirected therapy. Krueger 8 wrote that after the onset, psoriasis tends to wax and wane, but spontaneous remission is rare. Greaves and Weinstein 9 wrote that psoriasis plaques can regress spontaneously without scarring after weeks, months, or years.…”

mentioning

confidence: 99%

The Course of Chronic Plaque-Type Psoriasis in Placebo Groups of Randomized Controlled Studies

Spuls

Witkamp²,

Bossuyt³

et al. 2004

Arch Dermatol

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“…Recent findings, however, suggest that the mechanism is primarily immunological. The observation that drugs such as cyclosporine and methotrexate can reduce the symptoms of psoriasis, 4 combined with the discovery of activated, proliferating T‐cell infiltration in epidermal plaques, 5 strongly suggests that the disorder is due to alterations in the cell‐mediated immune response.…”

mentioning

confidence: 99%